CAS: 7598-61-0; Diethyl (2,2-Diethoxyethyl)Phosphonate

相似化合物

5191-35-5 867-13-0 867-13-0

上下游产品

Bromoacetaldehyde diethyl acetal triethyl phosphite chloroacetaldehyde diethyl acetal(2-oxoethyl)phosphonic acid diethyl ester hexaethyl benzene-1,3,5-tris(phosphonate) dibuthyl phosphonoacetaldehyde N-[(E)-2-diethoxyphosphorylethylideneamino]-4-methyl-benzenesulfonamide

📜2-溴-1,1-二乙氧基乙烷,亚磷酸三乙酯 以89%的收率获得产物2,2-二乙氧基乙基磷酸二乙酯
参考文献:带有β-Oxy或β-Thio取代基的α-官能化乙烯基膦酸酯的合成和合成利用.
标题:带有β-Oxy或β-Thio取代基的α-官能化乙烯基膦酸酯的合成和合成利用.
摘要:用lda或ltmp处理后的β-杂取代乙烯基膦酸酯1A-C易于在膦酰基的α-位被锂化,所得α-硫代乙烯基膦酸酯被各种亲电试剂捕获,得到相应的α-官能化乙烯基膦酸酯2-55-96%的收益率排名14.α-(甲硅烷基)-或α-(锗烷基)膦烯基二硫缩醛2,9或4与酰氯的friedel-Crafts反应以53-91%的收率获得产物α-酰化的膦烯酮二硫缩醛15-19.β-乙氧基-α-(三丁基锡烷基)乙烯基膦酸酯13与各种有机卤化物(r =酰基,烯丙基,芳基等)的钯催化交叉偶联反应提供了β-乙氧基-α-取代的乙烯基膦酸酯21-26中等至中等的产量.α-(碘)乙烯基膦酸酯7和14与末端乙炔的钯介导的交叉偶联反应以69-83%的收率得到α-炔基化乙烯基膦酸酯41-44.几种α-官能化的β-杂环取代的乙烯基膦酸酯被用于合成吡唑和具有膦酰基功能的异恶唑.
DOI:10.1021/jo980467G

专利信息

专利号:US-4980280-A
优先权日:1985-05-31
标 题:Conjugated polyene sterol derivatives as membrane probes
发明人：MORAND PETER; DREW JACINTA; SZABO ARTHUR G; PROULX PIERRE R
权利人:UNIV OTTAWA UNIVERSITE D OTTAW
摘要:The present invention relates to the synthesis of conjugated polyene sterol derivatives, the compounds obtained and to their use as fluorescent probes for cellular membranes. The fluorescent probes of the present invention resemble cholesterol both structurally and in amphipathic nature. The probes of the present invention have potential for use in determining cholesterol levels and cholesterol properties and cell membrane properties and can be applied to clinical assays and diagnoses involving cholesterol.