CAS: 722544-51-6; 2-(5-((7-(3-(Ethyl(2-Hydroxyethyl)Amino)Propoxy)Quinazolin-4-yl)Amino)-1H-Pyrazol-3-yl)-N-(3-Fluorophenyl)Acetamide

上下游产品

CAS号722544-46-9 2-(5-{[7-(3-chl... | CAS号110-73-6 乙基羟乙胺 | CAS号174891-10-2 (5-氨基-2H-吡唑-3-基)乙酸 | CAS号557770-89-5 7-(3-羟基-丙氧基)-3H... | CAS号557770-90-8 7-(3-氯丙氧基)-4-氯喹唑啉 | CAS号557770-91-9 [5-[7-(3-氯丙氧基)喹... | CAS号16499-57-3 7-氟-4-喹唑啉酮 | CAS号957881-03-7 3-[[7-[3-[乙基[2-...

4-Amino-7-{3-[ethyl(2-Hydroxyethyl)Amino]Propoxy}Quinazoline置于四丁基硫酸氢铵,Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应生成 5-[[7-[3-[乙基(2-羟基乙基)氨基]丙氧基]-4-喹唑啉]氨基]-N-(3-氟苯基)-1H-吡唑-3-乙酰胺
参考文献:巴拉塞替的制备方法
标题:巴拉塞替的制备方法
摘要:本发明公开了巴拉塞替的制备方法,所述巴拉塞替化学名称为2‑{5‑[(7‑{3‑[乙基(2‑羟基乙基)氨基]丙氧基}喹唑啉‑4‑基)氨基]‑1H‑吡唑‑3‑基}‑n‑(3‑氟苯基)乙酰胺,其化学式为c26H30Fn7O3;本发明制备工艺过程简洁,原料易得,经济环保,有利于实现工业化,可促进巴拉塞替原料药的经济技术发展,降低了反应生成成本,适于大批量生产.

专利信息

专利号:US-2024400576-A1
优先权日:2021-09-03
标 题:Nitrogen-containing derivatives of salinomycin, synthesis and uses thereof
发明人：RODRIGUEZ RAPHAËL; CZERWONKA DOMINIKA; ANTOSZCZAK MICHAL; HUCZYNSKI ADAM
权利人:CENTRE NAT RECH SCIENT; INST CURIE; INST NAT SANTE RECH MED; ADAM MICKIEWICZ UNIV
摘要:The present invention relates to nitrogen-containing derivatives of salinomycin having the formula (I), as well as pharmaceutically acceptable salt thereof, and synthesis and uses thereof, in particular for the treatment and/or prevention of cancer including for preventing cancer metastasis and/or for preventing cancer recurrence and/or for decreasing resistance to a chemotherapy in a subject.

专利号:US-2025250280-A1
优先权日:2021-09-03
标 题 :Nitrogen-containing derivatives of narasin, synthesis and uses thereof
发明人：RODRIGUEZ RAPHAËL; CAÑEQUE TATIANA; MÃœLLER SEBASTIAN; ANTOSZCZAK MICHAL
权利人:CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; INST CURIE
摘要:The present invention relates to nitrogen-containing derivatives of narasin having the formula (I), as well as synthesis and uses thereof, in particular for the treatment and/or prevention of cancer. Also disclosed are medicaments including the nitrogen-containing derivatives of narasin, which include medicaments for preventing cancer metastasis and/or for preventing cancer recurrence and/or for decreasing resistance to a chemotherapy in a subject.

专利号:WO-2023031399-A1
优先权日:2021-09-03
标题 :Iron-activable nitrogen-containing derivatives of salinomycin and narasin, synthesis and use for the treatment of cancers

专利号:WO-2023031402-A1
优先权日:2021-09-03
标 题 :Nitrogen-containing derivatives of salinomycin, synthesis and uses thereof

专利号:WO-2023031362-A1
优先权日:2021-09-03
标题:Nitrogen-containing derivatives of narasin, synthesis and uses thereof

专利号:EP-4396189-B1
优先权日:2021-09-03
标题 :Iron-activable nitrogen-containing derivatives of salinomycin and narasin, synthesis and use for the treatment of cancers
发明人：RODRIGUEZ RAPHAËL; CAÑEQUE TATIANA; MÃœLLER SEBASTIAN; ANTOSZCZAK MICHAL
权利人:CENTRE NAT RECH SCIENT; INST CURIE; INST NAT SANTE RECH MED