CAS: 6834-42-0; 2-(3-Methoxyphenyl)Acetyl Chloride

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CAS号1798-09-0 3-甲氧基苯乙酸 | CAS号79-37-8 草酰氯 | CAS号121-71-1 3-羟基苯乙酮 | CAS号621-37-4 3-羟基苯乙酸 | CAS号35553-92-5 3-甲氧基苯基乙酸乙酯 | CAS号144828-84-2 N-甲氧基-2-(3-甲氧基苯... | CAS号20772-11-6 1-Bromo-3-(3-me... | CAS号18463-71-3 2-(3-甲氧基苯基)乙酰胺 | CAS号3027-13-2 3-甲氧基苯基丙酮 | CAS号76413-89-3 5-甲氧基-2-茚满酮 | CAS号33543-62-3 [2-(3-甲氧基苯基)乙基]甲胺 | CAS号324570-26-5 4-(3-甲氧基苯基)-3-氧代丁酸 | CAS号114547-01-2 1-diazonio-3-(3... | CAS号720690-73-3 GSK189254A

3-羟基苯乙酸置于盐酸,Sodium Hydroxide,草酰氯体系中,用 苯 作为反应溶剂,化学反应 3.17H,反应生成 3-甲氧基苯基乙酰氯
参考文献:合成育亨宾类生物碱和新型合成的(+/-)-17-甲氧基-六氢育亨宾
标题:合成育亨宾类生物碱和新型合成的(+/-)-17-甲氧基-六氢育亨宾
摘要:已经开发出一种新的合成(+/-)-17-甲氧基-六氢杂亚氨基b烷(11)的方法,该方法可以通过一系列反应转化为育亨宾类生物碱.所需合成的方法是基于选择6-甲氧基-3-异苯并二氢吡喃酮(9)作为构建非氮基部分的合适合成子.氮部分是由色胺产生的.9和色胺的适当缩合产生(+/-)-17-甲氧基-六氢育亨宾.通过baeyer-Villiger氧化由5-甲氧基-2-茚满酮(3)制备为δ-内酯的6-甲氧基-3-异苯并二氢吡喃酮(9).通过独特的酸催化的重氮酮环化,已经开发出一种简单的合成3的方法.在这方面值得一提的是,酸催化的环化反应容易用3-甲氧基-苄基重氮甲基酮(8)进行,而4-甲氧基苄基重氮甲基酮(2)则不愿意环化.在该方向上的所有尝试均导致形成羟基酮(4)作为主要产物.
DOI:10.1016/s0040-4020(01)83466-9

专利信息

专利号:US-5623068-A
优先权日:1994-03-07
标 题:Synthesis of DNA using substituted phenylacetyl-protected nucleotides
发明人：REDDY M PARAMESWARA; FAROOQUI FIRDOUS; HANNA NAEEM B
权利人:BECKMAN INSTRUMENTS INC
摘要:Deoxyribonucleotide and ribonucleotide derivatives of the general formula I I wherein R1 represents -CR'R''-Ar, in which Ar is substituted aryl (as hereinafter defined) and R' and R'' are independently selected from the group consisting of hydrogen and lower alkyl; one of -R2 and R3 is a hydroxyl-protecting group and the other is a group suitable for synthesis of polynucleotides or for attachment of the nucleotide to a solid support; R4 is selected from the group consisting of hydrogen, -OH and protected hydroxyl; and B represents a divalent radical corresponding to a purine or pyrimidine base. When synthesis is carried out using these derivatives, the deprotection procedure is reduced to an essentially instantaneous process. The derivatives have acceptable shelf life and are very stable to conventional DNA synthesis conditions. Particularly preferred are those compounds wherein Ar is mono- and dihalo-substituted phenyl.

专利号:US-7098354-B2
优先权日:2002-10-25
标 题:Racemoselective synthesis of rac-diorganosilylbis(2-methylbenzo[e]indeyl)zirconium compounds
发明人：DAMRAU HANS-ROBERT; MUELLER PATRIK; GARCIA VALERIE; SIDOT CHRISTIAN; TELLIER CHRISTIAN; LELONG JEAN-FRANCOIS
权利人:BASELL POLYOLEFINE GMBH
摘要:The present invention relates to a specific process for the diastereoselective synthesis of rac-diorganosilylbis(2-methylbenzo[e]indenyl)zirconium compounds of the formula I, n nby reacting the silyl-bridged bisindenyl ligand with a dihalozirconium bis(3,5-di-tert-butylphenoxide)-base adduct to form the diorganosilylbis(2-methylbenzo[e]indenyl)zirconium bis(3,5-di-tert-butylphenoxide) and subsequently replacing the phenoxide groups by X using suitable replacement reagents to give the compound of the formula I; where the substituents X can be identical or different and are each F, Cl, Br, I or linear, cyclic or branched C 1-10 -alkyl; and the substituents R can be identical or different and are each linear, cyclic or branched C 1-10 -alkyl or C 6-10 -aryl; and also to the use of these compounds as catalysts.

专利号:US-6413957-B1
优先权日:1998-04-21
标题:Methods of inhibiting cell proliferation using indeno [1,2-c]pyrazol-4-ones
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
权利人:BRISTOL MYERS SUIBB PHARMA COM
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-8481501-B2
优先权日:2004-05-28
标 题 :Synthesis of metabolically stable analgesics, pain medications and other agents
发明人：CASHMAN JOHN R; MACDOUGALL JAMES M
权利人:CASHMAN JOHN R; MACDOUGALL JAMES M; HUMAN BIOMOLECULAR RES INST
摘要:Disclosed are analgesic-related compositions and methods of using the compositions for modulation of analgesic receptor activity. The compositions and methods are useful for reducing pain, as well as for therapeutic intervention of addictions or other diseases or disorders amenable to treatment or prophylaxis by modulation of analgesic receptor signaling.

专利号:US-7250435-B2
优先权日:1999-10-20
标 题:Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; VIDWANS ANUP P; YUE EDDY
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n nthat are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G.n n This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-7193099-B2
优先权日:2002-10-25
标 题:Racemoselective preparation of isolable ansa-metallocene biphenoxide complexes
发明人：DAMRAU HANS-ROBERT-HELLMUTH; MUELLER PATRIK; GARCIA VALERIE; SIDOT CHRISTIAN; TELLIER CHRISTIAN; LELONG JEAN-FRANCOIS
权利人:BASELL POLYOLEFINE GMBH
摘要:The invention relates to a process for preparing racemic metallocene biphenoxide complexes by reacting bridged transition metal complexes with cyclopentadienyl derivatives of alkali metals or alkaline earth metals and heating the reaction mixture obtained in this way to a temperature in the range from −78 to 250° C., to the corresponding metallocene biphenoxide complexes and to their use as catalysts or as constituents of catalysts for the polymerization of olefinically unsaturated compounds or as reagents or catalysts in stereoselective synthesis.