CAS: 625-98-9; 1-Chloro-3-Fluorobenzene

上下游产品

CAS号387-45-1 2-氯-6-氟苯甲醛 | CAS号346608-00-2 2-chloro-4-fluo... | CAS号541-73-1 间二氯苯 | CAS号57946-56-2 4-氯-2-氟苯胺 | CAS号108-42-9 间氯苯胺 | CAS号2252-51-9 2-氯-4-氟苯甲酸 | CAS号21900-54-9 2-氯-4-氟苯甲酰氯 | CAS号108-90-7 氯苯 | CAS号373-91-1 三氟甲基次氟酸酯 | CAS号121-73-3 间氯硝基苯 | CAS号500-41-4 3-氟二苯基胺 | CAS号372-19-0 3-氟苯胺 | CAS号462-06-6 氟苯 | CAS号372-18-9 1,3-二氟苯 | CAS号367-11-3 邻二氟苯 | CAS号348-62-9 4-氯-2-氟苯酚 | CAS号4863-91-6 3-氯-5-氟苯胺 | CAS号372-20-3 3-氟苯酚 | CAS号387-45-1 2-氯-6-氟苯甲醛 | CAS号404-71-7 异氰酸3-氟苯酯

3-硝基氯苯置于四甲基氟化铵体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 24.0H,以15%的收率获得产物3-氯氟苯
参考文献:通过芳基氟磺酸酯中间体对苯酚进行亲核脱氧氟化
标题:通过芳基氟磺酸酯中间体对苯酚进行亲核脱氧氟化
摘要:本报告描述了一种通过芳基氟磺酸 (Arofs) 中间体使用硫酰氟 (So2F2) 和四甲基氟化铵 (Nme4F) 对苯酚进行脱氧氟化的方法.我们首先证明 Arofs 与 Nme4F 的反应在温和条件下(通常在室温下)进行,以提供广泛的电子多样化和富含官能团的芳基氟化物产品.然后将该转化转化为使用 So2F2 和 Nme4F 的组合将苯酚一锅法转化为芳基氟化物.从头算计算表明,碳-氟键的形成是通过协调的过渡态而不是离散的迈森海默中间体进行的.
DOI:10.1021/jacs.6B12911

专利信息

专利号:US-2010016607-A1
优先权日:2006-12-11
标题:Process for the Synthesis of Highly Active Binary Metal Fluoride as a Fluorinating Agent for Aromatics
发明人：DOLBIER JR WILLIAM R; JANMANCHI KRISHNA MURTHY
权利人:UNIV FLORIDA
摘要:The subject invention relates to a process for the synthesis of highly active binary metal fluoride system for the fluorination of aromatic compounds. Fluorinated aromatic compounds are valuable synthons for the chemical synthesis of pharmaceutical drugs and novel polymers. Fluorobenzene is used to control carbon content in steel manufacturing, is an intermediate for pharmaceuticals, pesticides and other organic compounds. Fluorobenzene is typically produced by the reaction of aniline and sodium nitrite in the presence of hydrogen fluoride. The present invention relates to a process for the synthesis of highly active binary metal fluoride system consists of copper (II) fluoride and aluminum (III) fluoride for the fluorination of aromatic compounds in gas phase and recycling of the reagent, in situ, using O 2 and HF.

专利号:US-4049710-A
优先权日:1976-02-24
标题:Novel carbamimidoyl chlorides and their use in the synthesis of herbicidal triazinediones
发明人：TOCKER STANLEY
权利人:DU PONT
摘要:Carbamimidoyl chlorides of the formula: WHERE R2 is alkyl of 1-4 carbon atoms are useful as intermediates in the synthesis of herbicidal triazinediones of the formula: where R1 is certain organic radicals.

专利号:US-8071782-B2
优先权日:2007-10-02
标 题 :Synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles
发明人：DENG XIAOHU; MANI NEELAKANDHA S
权利人:DENG XIAOHU; MANI NEELAKANDHA S; JANSSEN PHARMACEUTICA NV
摘要:This invention concerns the synthesis of highly substituted pyrazoles, which are structural components of pharmacological compounds, through reaction of hydrazones with nitroolefins.

专利号:US-2013184465-A1
优先权日:2010-09-30
标 题:Process for the synthesis of thio-triazolo-group containing compounds
发明人：DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL
权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE
摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.

专利号:US-6017911-A
优先权日:1996-02-27
标 题 :Pyridonecarboxylic acid derivatives and intermediates for the synthesis thereof
发明人：HORIUCHI NOBUHIKO; YONEZAWA TAKENORI; CHIBA KATSUMI; YOSHIDA HIROAKI
权利人:DAINIPPON PHARMACEUTICAL CO
摘要:This invention relates to pyridonecarboxylic acid derivatives of the following general formula, esters thereof and salts thereof, as well as pharmaceutical preparations containing them. ##STR1## wherein: R is cycloalkyl which may be substituted by halogen, or the like; n X is hydrogen, lower alkyl, amino or the like; n Y is hydrogen or halogen; n A is nitrogen or a group of the formula C--Z in which Z is lower alkoxy that may be substituted by halogen, or the like; n R 1 and R 2 may be the same or different and are each hydrogen or the like; n R 3 is hydrogen or lower alkyl; n R 4 , R 5 , R 6 , R 7 , R 8 and R 9 may be the same or different and are each hydrogen, halogen or lower alkyl; n m is 0 or 1; and n n and p may be the same or different and are each 0 or 1. n This invention also relates to bicyclic amine compounds useful as direct intermediates for the synthesis of the above-described pyridonecarboxylic acid derivatives.

专利号:US-2008280855-A1
优先权日:2005-06-22
标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
发明人：CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH
摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.