CAS: 599-00-8; Trifluoroacetic Acid-D

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CAS号407-25-0 三氟乙酸酐(TFAH) | CAS号76-05-1 三氟乙酸(TFA) | CAS号3979-51-9 2-丙醇-OD | CAS号14848-63-6 iso-BuOD | CAS号925-94-0 甲酸-d | CAS号431-47-0 三氟乙酸甲酯(TFAM) | CAS号400-38-4 三氟乙酸异丙酯 | CAS号17355-83-8 Acetic acid, 2,... | CAS号65937-96-4 2'-(4-nitro-phe... | CAS号383-63-1 三氟乙酸乙酯 | CAS号21907-47-1 三氟乙酸锌水合物 | CAS号1076-43-3 氘代苯

📜三氟乙酸酐置于重水体系中,化学反应生成 氘代三氟乙酸
参考文献:4,8-脱水-2,3-二脱氧-D-半乳糖和-D-葡萄糖-非-3-烯丙基二甲基乙缩醛的合成及其作为1H-NMR光谱测定质子化过程的新探针的应用糖苷水解酶
标题:4,8-脱水-2,3-二脱氧-D-半乳糖和-D-葡萄糖-非-3-烯丙基二甲基乙缩醛的合成及其作为1H-NMR光谱测定质子化过程的新探针的应用糖苷水解酶
摘要:摘要通过多步合成法制备了标题非蔗糖衍生物2(d-Galacto)和4-(d-葡萄糖).仅通过来自大肠杆菌的相应酶β-D-半乳糖苷酶,来自生咖啡豆的α-D-半乳糖苷酶和来自甜杏仁的β-D-葡萄糖苷酶,α-D才将水加至这两种化合物的烯醇双键中.-酵母中的葡萄糖苷酶.在d 2 O中进行2的酶促水合以分析加成反应的空间过程,得到2,3-二脱氧-α-D-半乳糖-(3-2 H)-壬基-4-纤维素二甲基乙缩醛(5),当水解时,提供了以螺烷16和17为主要产物(85%)和稠环系统18和19为次要成分(15%)的平衡混合物.酶促水合产物的硼氢化物还原得到两种差向异构体14和15的可分离混合物,可在酸性甲醇中于62°转化8小时,分别转化为20和22.刚性的双环系统允许轻松地将单氘c-3上的构型指定为(S),从而可以确定酶催化起始步骤的空间过程,即底物中烯醇双键的氘化用过的.
DOI:10.1016/0008-6215(91)84092-S

专利信息

专利号:WO-9216541-A1
优先权日:1991-03-12
标 题 :Synthesis of sialic acid and synthetic intermediate therefor
发明人：SHIBA TETSUO; TESHIMA TADASHI; YAMAMOTO TOSHIHIRO
权利人:KANTO ISHI PHARMA CO LTD
摘要:An efficient synthesis of sialic acid (N-acetylneuramic acid) useful as the starting material of medicines, a synthetic intermediate therefor, isosialic acid as an isomer of sialic acid, synthesis thereof, and a synthetic intermediate therefor. Sialic acid is synthesized from D-glucose and oxaloacetic acid through the intermediates (Ia) and (IIIa), while isosialic acid represented by formula (IV) is synthesized from an isomer of the intermediate (Ia).

专利号:US-2023312596-A1
优先权日:2020-07-20
标题:Method for large-scale synthesis of tetrodotoxin
发明人：WANG GUANGYIN; LI XIAOMING; WANG CHENGXI; HUANG PING; BAI HUA; LAI LIANG; GUO PENG; JIANG BIAO; ZHU WENFENG
权利人:SHANGHAI SHENGPING MEDICAL EQUIPMENT CO LTD; SHANGHAI VASTPRO TECH DEVELOPMENT CO LTD; ZHEJIANG BOXIAO BIOPARMACEUTICAL CO LTD
摘要:The present invention provides a method for biological and chemical synthesis of tetrodotoxin, specifically comprising the following steps: using cheap and easily available benzyl acetate as a raw material, and performing biological fermentation to obtain an optically pure intermediate ((5S, 6R)-5, 6-dihydroxycyclohexa-1, 3-dienyl) methyl acetate (formula I); and performing a series of chemical conversions on the intermediate to finally obtain tetrodotoxin at a purity of 95% or more without purifying the product. The present invention has the potential of large-scale production, and is an excellent alternative to the existing extraction method from a pufferfish.

专利号:US-7592392-B2
优先权日:2003-04-04
标 题 :Synthesis of functional polymers for use in organic synthesis and combinatorial chemistry
发明人：LINDSLEY CRAIG W; WISNOSKI DAVID D
权利人:MERCK & CO INC
摘要:The present invention relates to a novel process for the preparation of solid-supported scavenging reagents and solid-supported functional polymers. The invention further relates to novel solid-supported functional polymers and to their use in organic synthesis and combinatorial chemistry.

专利号:US-6506577-B1
优先权日:1998-03-19
标题:Synthesis and crosslinking of catechol containing copolypeptides
发明人：DEMING TIMOTHY J; YU MIAOER
权利人:UNIV CALIFORNIA
摘要:The synthesis of moisture-resistant adhesive polypeptides, conditions for their use, and conditions for controlling characteristics of the crosslinked matrix are disclosed. By specifically manipulating the conditions under which these networks are formed, the characteristics of the networks may be precisely regulated. These manipulatable adhesive networks are water-based, show exceptional bonding capabilities toward wet materials (including biological tissues), and have a variety of biotechnological applications.

专利号:US-7335717-B2
优先权日:1998-12-18
标 题 :Methods, compositions, and biomimetic catalysts for the synthesis of silica, polysilsequioxanes, polysiloxanes, non-silicon metalloid-oxygen networks, polymetallo-oxanes, and their organic or hydrido conjugates and derivatives
发明人：MORSE DANIEL E; KISAILUS DAVID; ROTH KRISTIAN M
权利人:UNIV CALIFORNIA
摘要:The in vitro polymerization of silica, silicone, non-silicon metalloid-oxane and metallo-oxane polymer networks, by combining a catalyst and a substrate to polymerize the substrate to form silica, polysiloxanes, polymetalloid-oxanes polymetallo-oxanes (metal oxides), polyorganometalloid oxanes, polyorganometallo oxanes, and the polyhydrido derivatives thereof, at about neutral pH. The nanostructure-directing catalysts have a nucleophilic functionality and a hydrogen-bonding acceptor group, and include: silicateins, enzymes that work by a mechanism functionally related to that of the silicateins; self-assembling peptides related to those synthesized and demonstrated capable of acting as biomimetic substitutes for the silicateins; non-peptide-based synthetic polymers containing a nucleophilic group and a hydrogen bonding amine such that the polymer functions by a mechanism of action related to that of the silicateins; materials having such chemical functionality as a nucleophilic group and or a hydrogen bonding amine which, acting in concert with nanoconfinement and or chemical functionality of the surface or matrix to which the functionality is attached, acts catalytically by a mechanism related to that of the silicateins; and small-molecule non-polymeric biomimetic catalysts that operate by the same mechanism as silicateins.

专利号:US-2009234121-A1
优先权日:2008-01-16
标 题 :Tridentate (nnc) catalysts for the selective oxidation of hydrocarbons
发明人：PERIANA ROY A; GODDARD III WILLIAM A; OXGAARD JONAS; YOUNG KENNETH
权利人:PERIANA ROY A; GODDARD III WILLIAM A; OXGAARD JONAS; YOUNG KENNETH
摘要:The synthesis of discrete, air, protic, and thermally stable transition metal NNC complexes that catalyze the CH activation and functionalization of alkanes and arenes is disclosed. Methods for the selective conversion of methane to methanol or methyl esters in acidic and neutral media are disclosed.