专利号:US-2023313255-A1 优先权日:2020-07-15 标题:Massively Parallel Enzymatic Synthesis of Polynucleotides 发明人:HORGAN ADRIAN; LACHAIZE HENRI; VERARDO DOMIANO; GODRON XAVIER 权利人:DNA SCRIPT 摘要:The invention is directed to methods and compositions for inkjet assisted synthesis of a plurality of polynucleotides at reaction sites on a substrate using template-free polymerases, such as, terminal deoxynucleotidyl transferases (TdTs). Compositions of the invention include formulations of synthesis reagents for inkjet delivery including, but not limited to, TdT coupling reaction buffers and 3′-O-protected dNTP monomers.
专利号:US-7601318-B2 优先权日:2000-09-26 标 题:Method for synthesis of carbon-coated redox materials with controlled size 发明人:ARMAND MICHEL; GAUTHIER MICHEL; MAGNAN JEAN-FRANCOIS; RAVET NATHALIE 权利人:HYDRO QUEBEC; CENTRE NAT RECH SCIENT; UNIV MONTREAL 摘要:A method for the synthesis of compounds of the formula C—Li x M 1−y M′ y (XO 4 ) n , where C represents carbon cross-linked with the compound Li x M 1−y M′ y (XO 4 ) n , in which x, y and n are numbers such as 0≦x≦2, 0≦y≦0.6, and 1≦n≦1.5, M is a transition metal or a mixture of transition metals from the first period of the periodic table, M′ is an element with fixed valency selected among Mg 2+ , Ca 2+ , Al 3+ , Zn 2+ or a combination of these same elements and X is chosen among S, P and Si, by bringing into equilibrium, in the required proportions, the mixture of precursors, with a gaseous atmosphere, the synthesis taking place by reaction and bringing into equilibrium, in the required proportions, the mixture of the precursors, the procedure comprising at least one pyrolysis step of the carbon source compound in such a way as to obtain a compound in which the electronic conductivity measured on a sample of powder compressed at a pressure of 3750 Kg·cm −2 is greater than 10 −8 S·cm −1 . The materials obtained have excellent electrical conductivity, as well a very improved chemical activity.
专利号:US-2023287032-A1 优先权日:2020-08-14 标 题:Synthesis of fluorinated nucleotides 发明人:CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO 权利人:CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO; MERCK SHARP & DOHME LLC 摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (O—{[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl}O,O-dihydrogen phosphorothioate, also known as 2′-(S)-fluoro-thio-adenosine monophosphate or 2′-F-thio-AMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.
专利号:US-2023399294-A1 优先权日:2022-06-08 标 题 :Method for synthesis of monomer for single-ion battery 发明人:ZHAO QIUJIE; LIANG SIWEI; YANG JIN; DEGRAS Sarah; LEBLANC PATRICK 权利人:BLUE SOLUTIONS CANADA INC; CAPACITOR SCIENCES INC 摘要:The present technology relates to methods for the synthesis of a lithium single-ion monomer which comprises simultaneously reacting a sulfonyl chloride compound with i) a fluorinated sulfonamide compound and ii) a compound that is suitable to act as a quenching base and a lithium cation source. The simultaneous reaction of sulfonyl chloride with the fluorinated sulfonamide compound and the compound that is suitable to act as a quenching base and a lithium cation source yields the single-ion monomer.
专利号:US-2024052391-A1 优先权日:2020-10-29 标 题 :Enzymatic Synthesis of Polynucleotide Probes 发明人:GODRON XAVIER; NIYOMCHON SUPAPORN; CHAMPION ELISE 权利人:DNA SCRIPT 摘要:The present invention is directed to methods and kits for enzymatic synthesis of labeled polynucleotide probes using template-free DNA polymerases.
专利号:US-10944106-B2 优先权日:2018-06-25 标题 :Metal oxide and synthesis of lithium ion battery 发明人:CHEN PENGWEI; WANG MENG; XU LEIMIN; WANG LIANG 权利人:NINGDE AMPEREX TECHNOLOGY LTD 摘要:The present application relates to a metal oxide and synthesis of a lithium ion battery. Specifically, the present application selects a cobalt oxide compound, which uses Co3O4 as a main body, as a precursor of lithium cobalt oxide, and anion doping is performed in particles of Co3O4 to obtain a doped precursor for lithium cobalt oxide. The general formula of the precursor can be expressed as Co3(O1-yMy)4, where about 0
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