CAS: 542-81-4; (2-Chloroethyl)(Methyl)Sulfane

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693-07-2 25059-70-5 19987-13-4

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2-甲硫基乙醇置于4-二甲氨基吡啶,氯化亚砜体系中,用 氯仿 作为反应溶剂,化学反应 6.0H,反应生成 2-氯乙基甲基硫醚
参考文献:合成和结合亲和力的新型重新包含7Alpha取代雌二醇复合物:乳腺癌成像剂的模型.
标题:合成和结合亲和力的新型重新包含7Alpha取代雌二醇复合物:乳腺癌成像剂的模型.
摘要:乳腺癌的诊断和分期可以通过影像学放射性药物的开发来改善,该成像药物可以无创地确定肿瘤细胞中雌激素受体的状态.为了实现这一目标,我们合成了许多新型的含re的7α-取代的雌二醇复合物.7α侧链的引入涉及四氢吡喃氧基保护的6-酮雌二醇的烷基化.引入metal金属的方法包括" 3 +1"和" 4 +1"混合配体配合物(分别为2A-C和5),三羰基二硫醚配合物(3)和环戊二烯基三羰基金属有机金属体系(4Ab,6). 7).这些复合物显示出对雌激素受体的结合亲和力(" 3 +1"的亲和力高达45%与天然的配体雌二醇相比,复合物2C).通过将(聚)醚键引入7Alpha侧链(6,7),对某些复合物(4Ab)的极性进行了修饰,以改善生物分布特性.这些复合物为我们对雌激素受体的配体结构-结合亲和力相关性的理解提供了进一步的完善,并且为合成类似的tc-99M复合物作为乳腺肿瘤成像剂进行评估提供了合成基础.
DOI:10.1021/jo990641G

专利信息

专利号:US-5523411-A
优先权日:1994-03-14
标题 :Synthesis of mitomycin and its analogs
发明人：JIMENEZ LESLIE; WANG ZHENG
权利人:UNIV RUTGERS
摘要:The present invention relates to the synthesis of mitomycin and analogs thereof that are useful as anticancer antibiotics. The invention further relates to analogs of mitomycin, which can be prepared according to the methods of synthesis provided. The synthetic method of the invention provides for reacting a derivitized indole with a dialkylvinylsulfonium salt to yield a tricyclic skeleton having the precursors of the fourth ring in one step, followed by an oxidation step or steps to close the fourth ring and prepare mitomycin or a related compound.

专利号:US-2023407352-A1
优先权日:2020-10-30
标题:Method for the Production of Thiocarbamate Derivatives A2AR Inhibitors
发明人：JIAO XUECHENG; DELIGNY MICHAEL; CROSIGNANI STEFANO; JIANG XIANGJUN
权利人:iTeos Belgium SA
摘要:The present disclosure relates to synthesis of enantiomerically rich key drug intermediates as a means for manufacturing of thiocarbamate derivatives as A2A adenosine receptor (A2AR) inhibitors. More particularly, the present disclosure provides a viable efficient technology using enzymatic biotransformation process which utilizes cheaper substrate for production of high value key intermediates for A2AR inhibitors.

专利号:US-2485116-A
优先权日:1947-05-28
标 题:Synthesis of dl-methionine
发明人：KENNETH SAVARD
权利人:AYERST MCKENNA & HARRISON

专利号:US-7947722-B2
优先权日:2006-07-28
标 题:Imidazolidinone derivative, method of producing the same and method of producing optically active amino acid
发明人：SAKA YASUHIRO; FUJII AKIO; OKURO KAZUMI; MITSUDA MASARU
权利人:KANEKA CORP
摘要:The objective of the present invention is to provide an optically active imidazolidinone derivative widely usable for synthesizing an optically active amino acid, a method of easily producing the derivative, and a method of easily producing an optically active amino acid by using the derivative. The objective can be achieved by producing an optically active amino acid using a novel optically active imidazolidinone derivative represented by a general formula (3) and the like. According to the method of the present invention, an optically active imidazolidinone derivative can be obtained by preferential crystallization from a mixture of isomers of the imidazolidinone derivative. Therefore, an optically active amino acid can be easily and stereoselectively produced without cumbersome procedures required for the conventional methods, such as resolution of diastereomers, synthesis from an optically active amino acid and resolution of isomers by silica gel column chromatography.

专利号:US-5202444-A
优先权日:1990-11-27
标题:Optically isomeric inositol and process for making optically active compound
发明人：OZAKI SHOICHIRO; AKIYAMA TAKAHIKO; KAGEYAMA KUNIO; MACHIDA MORIHISA
权利人:YOKOHAMA RUBBER CO LTD
摘要:Optically active diols and hydroxycarboxylic acids and their esters are produced by deriving 1L-1,2:5,6-di-O-cyclohexylidene-chiro-inositol from 1L-chiro-inositol as an asymmetric source, followed by introduction of a selected class of sterically hindering and asymmetrically reactive groups into the first-mentioned compound and by subsequent reduction of the resulting compound. Seven specific inositols are also derivable from synthesis of those ultimate compounds.

专利号:US-4107176-A
优先权日:1976-04-23
标题:Mono-N-tosylsulfimides, their preparation and their reaction products
发明人：EVANS DAVID H; GREENWALD RICHARD B
权利人:POLAROID CORP
摘要:This application is directed to cycloalkanes containing the moiety -SO2-CH2-X- wherein X represents +TR wherein R is hydrogen or alkyl and R' is alkyl and to the preparation of these compounds which find utility as silver halide complexing agents. This application is also concerned with cycloalkanes containing the moiety useful as intermediates in the preparation of the aforementioned compounds. Also included within the confines of this disclosure are the 2-thioether-substituted derivatives of certain of the above-identified cycloalkanes and with the synthesis of all of these compounds.