CAS: 518-20-7; Cyclocumarol
该化合物是一种合成化合物,被归类为以其抗coagulant特性而闻名的科马林衍生物,其特征为双环结构,包括一种有助于其生物活动的科马林混合物,该化合物一般为白色至白晶状固体,在有机溶剂中表现出中等溶解性,在水中溶解性有限;Cyclocoumaol功能,通过抑制维生素K 过氧化剂再排气酶,这是合成维生素K依赖性凝凝聚物的一种关键酶,从而影响血液凝聚;其药理学特征包括了在预防和治疗输血管紊乱方面的潜在应用;然而,与其他抗凝胶剂一样,由于出现出血并发症的风险,该化合物需要仔细监测,其稳定性,反应力和与其他药物的相互作用是其治疗用途中的重要考虑因素.
- ⚠️《化妆品禁用原料目录》
- 英文名称Cyclocumarol
- 中文名称环香豆素
- IUPAC名称2-methoxy-2-methyl-4-phenyl-3,4-dihydro-2H,5H-pyrano[3,2-c]chromen-5-one
- 其它别名3,4-Dihydro-2-Methoxy-2-Methyl-4-Phenyl-2H,5H-Pyrano[3,2-C][1]-Benzopyran-5-One; Pyranocoumarin; Pyranocumarin; 2H,5H-Pyrano(3,2-C)(1)Benzopyran-5-One,3,4-Dihydro-2-Methoxy-2-Methyl-4-Phenyl; 2H,5H-Pyrano[3,2-C][1]Benzopyran-5-One, 3,4-Dihydro-2-Methoxy-2-Methyl-4-Phenyl-; 2-Methoxy-2-Methyl-4-Phenyl-3,4-Dihydro-2H,5H-Pyrano[3,2-C]Chromen-5-One; 2-Methyl-2-Methoxy-4-Phenyl-3,4-Dihydro-Pyrano-(3,2-C)-Cumarin; 3,4-Dihydro-2-Methoxy-2-Methyl-4-Phenyl-2H,5H-Pyrano(3,2-C)(1)Benzopyran-5-O
- CAS编号518-20-7
- MFCD编号:MFCD00078734
- EINECS号:208-248-3
- FDA UNII编号:725P8AW50M
- 分子式:C20H18O4分子量:322.36
- 产品CID: 1508588
- 产品分类分析化学 → 标准品 → 化妆品标准品
物理性质
MSDS等安全信息
欧盟法规
ECHA物质ECHA物质化妆品禁用物质清单C&L通报REACH预注册上下游产品
methanol warfarin 4-hydroxy[1]benzopyran-2-one (E)-benzalacetonewarfarin 2-methyl-4-phenylpyrano[3,2-c]chromen-5(4H)-one warfarin合成工艺路线路线简述
📜苄叉丙酮置于吡啶,盐酸体系中,化学反应生成 环香豆素
参考文献:Studies On 4-Hydroxycoumarins. V. The Condensation Of α,β-Unsaturated Ketones With 4-Hydroxycoumarin1
标题:Studies On 4-Hydroxycoumarins. V. The Condensation Of α,β-Unsaturated Ketones With 4-Hydroxycoumarin1
摘要:
DOI:10.1021/ja01234A019
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2905142000-仲丁醇
2909199090-其他醚及其衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications
专利号:AU-2007308022-B2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Rayar AM, Lagarde N, Martin F, Blanchard F, Liagre B, Ferroud C, Zagury JF, Montes M, Sylla-Iyarreta Veitía M. New selective cyclooxygenase-2 inhibitors from cyclocoumarol: Synthesis, characterization, biological evaluation and molecular modeling. Eur J Med Chem. 2018 Feb 25;146:577-587. doi: 10.1016/j.ejmech.2018.01.054. Epub 2018 Jan 31.
3: MARION P, COLPRON G, LONG LA. [Study of cyclocumarol, its clinical aspects and its depressive action on prothrombin and on proconvertin]. Union Med Can. 1955 Apr;84(4):426-30. French.
合成参考文献
参考文献:10.1007/bf02976373
摘要:Huong DTL, Choi HC, Rho TC, Lee HS, Lee MK, Kim YH. Inhibitory activity of monoamine oxidase by coumarins fromPeucedanum japonicum. Archives of Pharmacal Research. 1999 Jun;22(3):324–6. doi: 10.1007/bf02976373.
参考文献:10.1006/abbi.1999.1468
摘要:He M, Korzekwa KR, Jones JP, Rettie AE, Trager WF. Structural Forms of Phenprocoumon and Warfarin That Are Metabolized at the Active Site of CYP2C9. Archives of Biochemistry and Biophysics. 1999 Dec;372(1):16–28. doi: 10.1006/abbi.1999.1468.
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尽可能描述清楚需求与问题信息
