CAS: 515-25-3; Betonicine

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4-hydroxyproline methyl iodide diazomethane 4R-4-hydroxyproline

专利信息

专利号:US-11612556-B2
优先权日:2014-12-16
标 题:Peptidic compounds, compositions comprising them and uses of said compounds, in particular cosmetic uses
发明人：PESCHARD OLIVIER; DOUCET ANNE; LEROUX RICHARD; MONDON PHILIPPE
权利人:SEDERMA SA
摘要:The peptidic compound comprises at least an aminoacid which is lysine, ornithine, diaminopropionic acid or diaminobutyric acid or a derivative of these aminoacids, on which a carboxylic acid is grafted via a peptidic bound on the nitrogen of the lateral chain, said carboxylic acid comprising a (poly)cycle or (poly)heterocycle. Preferably, the grafted carboxylic acid is an aminoacid or a derivative, in particular selected from, a proline, a hydroxyproline or pyroglutamic acid.The peptidic compound can stimulate the synthesis of the main molecules constituting the extracellular matrix of the skin, especially collagen 1 and 4 and elastin. It can be used for topical cosmetic treatment such as a global anti-aging treatment, or for specific activities, including anti-wrinkles, moisturizing, to improve the mechanical properties of the skin, firmness/tone/elasticity/flexibility, to increase density and volume of the skin, improve skin radiance, for a restructuring effect and/or to fight stretch marks.

专利号:WO-2007107319-A1
优先权日:2006-03-17
标题:Isolation, structure determination, synthesis and bioactivity of damipipecolin and damituricin
发明人：AIELLO ANNA; GIORDANO ANTONELLA; FATTORUSSO ERNESTO; MENNA MARIALUISA; SCHROEDER HEINZ C; MUELLER WERNER E G
权利人:BIOTECMARIN GMBH; AIELLO ANNA; GIORDANO ANTONELLA; FATTORUSSO ERNESTO; MENNA MARIALUISA; SCHROEDER HEINZ C; MUELLER WERNER E G
摘要:Two new bromopyrrole alkaloids, compounds (1) and (2), have been isolated from the Mediterranean sponge Axinella damicÏ…rnis, and their structure established through spectroscopic methods. Compounds (1) and (2 )display a modulating effect of the serotonin receptor activity and neuroprotective activity in vitro.

专利号:CN-1299419-A
优先权日:1998-03-13
标题:Compositions and method for enhanced synthesis of nucleic acid molecules