N-丁基苯胺置于cobalt Chloride,氢溴酸体系中,化学反应生成 对丁基溴苯 参考文献:Reilly; Hickinbottom,Journal Of The Chemical Society,1920,Vol. 117,P. 133 标题:Reilly; Hickinbottom,Journal Of The Chemical Society,1920,Vol. 117,P. 133
专利号:US-7465802-B2 优先权日:2006-12-13 标 题:Facile synthesis of a series of liquid crystalline 2-(4′-alkylphenyl)-5-cyanopyridines 发明人:CHIA WIN-LONG; LU RU-SUNG 权利人:UNIV FU JEN CATHOLIC 摘要:The invention relates to a facile synthesis of a series of 2-(4′-alkylphenyl)-5-cyanopyridine liquid crystal compounds which are represented by the following formula (I): n nwherein C n is a linear alkyl having 1-12 carbon atoms. The synthesis of the liquid crystalline 2-(4′-alkylphenyl)-5-cyanopyridine is completed in a two-step reaction. First, a Grignard reagent (such as 4-alkylphenylmagnesium bromide) is added to a 3-cyanopyridinium salt (such as N-phenyloxycarbonyl-3-cyanopyridinium chloride) to get a 1,2-dihydropyridine. Then the 1,2-dihydropyridine is oxidized with o-chloronil to obtain the 2-(4′-alkylphenyl)-5-cyanopyridine.
专利号:WO-2017082924-A1 优先权日:2015-11-13 标题 :Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use 发明人:BURKE TERRENCE R JR; HYMEL DAVID 权利人:THE US SECRETARY DEPT OF HEALTH & HUMAN SERVICES 摘要:The description provides novel compounds that may serve as anticancer therapeutics. The compounds of the description bind to polo-like kinases through the polo-box domain. The peptide derivatives of the description have achieved improved efficacy in biochemical assays against Plk1. The description also provides methods of use, methods of preparation, compositions, and kits thereof. Further, the description provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.
专利号:US-2008146813-A1 优先权日:2006-12-13 标 题 :Facile synthesis of a series of liquid crystalline 2-(4'-alkylphenyl)-5-cyanopyridines
专利号:US-7999090-B2 优先权日:2000-07-07 标 题:Fungal cell wall synthesis gene 发明人:TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO 权利人:EISAI R&D MAN CO LTD 摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.
专利号:WO-2007109365-A2 优先权日:2006-03-21 标题 :Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide
专利号:EP-1996572-A2 优先权日:2006-03-21 标 题:Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide
参考标题:Synthesis Of Aromatic Carboxylic Acids By Carbonylation Of Aryl Halides In The Presence Of Epoxide-Modified Cobalt Carbonyls As Catalysts 作者:V. P. Boyarskii,T. E. Zhesko,S. A. Lanina |发布日期:2005.11 摘要:A New Procedure Was Developed For Synthesis Of Aromatic And Heteroaromatic Acids And Their Derivatives (Esters, Salts) By Carbonylation Of The Corresponding Aryl Halides. The Acids Are Selectively Formed In A High Yield Under Very Mild Conditions. Highly Active Catalytic Systems, Base-Containing Alcoholic Solutions Of Cobalt Carbonyl Modified With Epoxides, Were Used To Activate Aryl Halides.
合成参考文献
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