CAS: 3744-87-4; Boc-Dl-Ala-Oh

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CAS号338-69-2 D-丙氨酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号79069-13-9 N-B°C-L-丙氨醇 | CAS号73371-96-7 2-[[(tert-butox... | CAS号3744-87-4 B°C-DL-丙氨酸 | CAS号64-17-5 乙醇 | CAS号15761-38-3 叔丁氧羰基-L-丙氨酸 | CAS号3744-87-4 B°C-DL-丙氨酸 | CAS号51814-53-0 γ-(p-Anisidino)... | CAS号3392-05-0 叔丁氧羰基-L-丙氨酸 N-丁二酰亚胺酯 | CAS号91103-47-8 B°C-D-丙氨酸甲酯 | CAS号186521-98-2 (3S)-3-b°C-氨基-1... | CAS号338-69-2 D-丙氨酸 | CAS号34404-33-6 N-[(叔丁氧基)羰基]-D-... | CAS号71810-97-4 D-丙氨酰胺盐酸盐 | CAS号100927-09-1 (R)-2-(B°C-氨基)丙腈

Dl-丙氨酸 反应生成 Boc-Dl-丙氨酸
参考文献:Mendes,Etienne;Vernieres,Jean-Claude;Keane,Peter Eugene;Bachy,Andre
标题:Mendes,Etienne;Vernieres,Jean-Claude;Keane,Peter Eugene;Bachy,Andre

专利信息

专利号:US-7288661-B2
优先权日:2003-12-10
标 题 :Process for the synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]-octahydro-1H-indole-2-carboxylic acid compounds and application in the synthesis of perindopril
发明人：DUBUFFET THIERRY; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the synthesis of compounds of formula (I): n nwherein R represents a hydrogen atom or a protecting group for the amino function.n n Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.

专利号:US-7060842-B2
优先权日:2001-07-24
标题 :Method for synthesis of (2S, 3aS, 7aS)-1-{(S)-alanyl}-octahydro-1H -indole-2-carboxylic acid derivatives and use for synthesis of perindopril
发明人：MEZEI TIBOR; PORCS-MAKKAY MARTA; SIMIG GYULA
权利人:SERVIER LAB
摘要:Process for the industrial synthesis of the compounds of formula (I): n nwherein R 1 represents a hydrogen atom or an alkyl or benzyl group, and R 2 represents a group that protects the amino function.

专利号:US-5714127-A
优先权日:1992-10-08
标题 :System for multiple simultaneous synthesis
发明人：DEWITT SHEILA H H; KIELY JOHN S; PAVIA MICHAEL R; SCHROEDER MEL C; STANKOVIC CHARLES J
权利人:WARNER LAMBERT CO
摘要:A system for the multiple, simultaneous synthesis of compounds preferably uses a reaction apparatus comprising a reservoir rack having a plurality of reaction wells, a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends, a holder block, having a plurality of apertures, and a manifold, which has ports to allow introduction/maintenance of a controlled environment. The manifold top wall has a plurality of apertures in axial alignment with the reaction tubes and a gasket which allows penetration by a needle in order to dispense and aspirate materials from the reaction tubes. Sealing members, such as gaskets, are placed between the holder block, manifold and reservoir rack and the components are releasably fastened together. A robotic sample processor is used to automate the synthesis process using the reaction apparatus.

专利号:US-7157485-B2
优先权日:2003-02-28
标题 :Method for synthesizing derivatives of (2S,3AS,7AS)-1-[(S)-alanyl]-octahydro,-1H-indole-2-carboxylic acid and the use thereof for perindopril synthesis
发明人：DUBUFFET THIERRY; LANGLOIS PASCAL
权利人:SERVIER LAB
摘要:Process for the synthesis of compounds of formula (I): n nwherein R 1 represents hydrogen, alkyl or benzyl and R 2 represents a protecting group for the amine function.n n Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.

专利号:US-5702672-A
优先权日:1992-10-08
标 题 :Apparatus and method for multiple simultaneous synthesis
发明人：DEWITT SHEILA H H; KELL MICHAEL; PAVIA MICHAEL R; KIELY JOHN S; SCHROEDER MEL C; STANKOVIC CHARLES J; WARE STEVEN
权利人:WARNER LAMBERT CO
摘要:An apparatus for multiple, simultaneous synthesis of compounds which consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold.

专利号:US-5766556-A
优先权日:1992-10-08
标题:Apparatus and method for multiple simultaneous synthesis
发明人：DEWITT SHEILA HELEN HOBBS; KIELY JOHN STEVEN; PAVIA MICHAEL RAYMOND; SCHROEDER MEL CONRAD; STANKOVIC CHARLES JOHN
权利人:WARNER LAMBERT CO
摘要:An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold. The apparatus provides in excess of 1 mg of each product with structural knowledge and control over each compound. The apparatus can be adapted to manual, semiautomatic or fully automatic performance. Using the apparatus a series of building blocks are covalently attached to a solid support. These building blocks are then modified by covalently adding additional different building blocks or chemically modifying some existing functionality until the penultimate structure is achieved. This is then cleaved from the solid support by another chemical reaction into the solution within the well yielding an array of newly synthesized individual compounds, which after postreaction modification, if necessary, are suitable for testing for activity.