CAS: 36865-41-5; 1-Bromo-3-Methoxypropane

该化合物是一种卤化醚化合物,通常用作有机合成中的烷基剂,其主要优点包括反应性溴协会,它有利于核生殖替代反应,以及增加极地溶剂溶解性的甲氧合金集团,该化合物在制药,农用化学品和特殊化学品生产中特别宝贵,因为它能够有效引进甲氧丙基组,在标准储存条件下具有良好稳定性,符合一系列反应条件.

英文名称1-Bromo-3-Methoxypropane
中文名称1-溴-3-甲氧基丙烷
IUPAC名称1-bromo-3-methoxypropane
其它别名3-溴丙基甲基醚; 3甲氧基1溴丙烷; Propane, 1-Bromo-3-Methoxy-; 1-Bromo-3-Methoxypropane
CAS编号36865-41-5
MFCD编号:MFCD02258473
EINECS号:609-300-1
FDA UNII编号:2AYZ4QY8KT
分子式:C4H9BrO
分子量:153.02
产品CID: 1377918
产品分类有机原料→分子砌块→脂肪链类化合物

相似结构搜索
InChIKey: CEVMYGZHEJSOHZ-UHFFFAOYSA-N
InChI=1S/C4H9BrO/c1-6-4-2-3-5/h2-4H2,1H3…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数3.0

相似化合物

627-18-9 4457-67-4 58929-72-9

MSDS等安全信息

GHS象形图
GHS符号GHS02;
注释: Flame
危险类别易燃液体类别3
急性毒性类别3(吸入)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
严重眼刺激类别2
警示词Warning(警告)
危险描述H226 |易燃液体和蒸气.
H331 |吸入会中毒.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P210-P233-P240-P241-P242-P243-P264-P280-P362-P370+P378-P501
危险等级3
UN编号1993.0
危险品标志Xi
包装等级Ⅲ
安全声明26-36/37/39
危险类别码36/37/38

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

3-甲氧基-1-丙醇置于三溴化磷体系中,化学反应生成1-溴-3-甲氧基丙烷
参考文献:Npy Antagonists,Preparation And Uses
标题:Npy Antagonists,Preparation And Uses
摘要:本发明涉及新颖化合物,它们的制备和用途,特别是在治疗方面的用途.更具体地说,它涉及至少具有两个芳香环的衍生化合物,它们的制备和用途,特别是在人类或动物健康领域.这些化合物对存在于中枢和外周神经系统中的神经肽y(npy)的生物受体具有亲和力.本发明的化合物优选为npy拮抗剂,更具体地说是npy Y1亚型的拮抗剂,因此可用于治疗或预防涉及npy的任何疾病.本发明还涉及含有所述化合物的药物组合物,其制备和用途,以及使用所述化合物的治疗方法.

海关参考信息

2905121000-正丙醇
2903399020-溴甲烷
2909199090-其他醚及其衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-2011148392-A1
优先权日:2010-05-28
标题 :Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof
发明人：SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY
权利人:MSN LAB LTD; SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY
摘要:The present invention relates to a process for the preparation of (2S,4S,5S,7S)-N-(2- Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxy propoxy )phenyl]-octanamide compound of formula- 1 and its pharmaceutically acceptable salts thereof. Further, relates to the processes for the preparation of (R)-4-(2-(halomethyl)-3- methylbutyl)-l-methoxy-2-(3-methoxypropoxy) benzene and (R)-2-(4-methoxy-3-(3-methoxy propoxy) benzyl)-3-methyIbutan-l-ol useful intermediates in the synthesis of compound of formula- 1.

专利号:WO-2012078147-A1
优先权日:2010-12-08
标题:A process for the preparation of intermediates useful in the production of aliskiren
发明人：BHANU MANJUNATH NARAYAN; NAIK SAMIR; THOMAS REJOY
权利人:WATSON LAB INC; BHANU MANJUNATH NARAYAN; NAIK SAMIR; THOMAS REJOY
摘要:A process for preparing 4-[(2R)-2-X-methyl)-3-methylbutyl]-1 -methoxy-2-3(3- methoxypropoxy)-benzene wherein X is a leaving group and use of this compound in the synthesis of aliskiren.

专利号:US-2011040105-A1
优先权日:2008-04-16
标题 :Processes useful for the synthesis of (r)-1--2-methyl-pyrrolidine
发明人：HUBER CHRISTIAN H; KHULMAN YOUNG MI; TANDEL SAGUN K; JOHANNSEN STEPHEN R; WANG TINGMIN; ANGELL PAUL
权利人:ARENA PHARM INC
摘要:Processes useful for making a pharmaceutically useful compound according to Formula (I), forms of such a compound, and intermediates useful in such processes are described.

专利号:US-5470973-A
优先权日:1994-10-03
标题 :Synthesis of sulfonamide intermediates
发明人：HOFF ROMAN
权利人:ALCON LAB INC
摘要:Enantioselective syntheses of (S)-6-chloro-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazin-4-ol 1,1-dioxide and related compounds are described.

专利号:US-2014303333-A1
优先权日:2011-10-14
标题:Iron bisphenolate complexes and methods of use and synthesis thereof
发明人：SHAVER MICHAEL P; KOZAK CHRISTOPHER M
权利人:UNIV PRINCE EDWARD ISLAND; GENESIS GROUP INC
摘要:The present application, relates to iron bisphenolate complexes and methods of use and synthesis thereof. The iron complexes are prepared from tridentate or tetradentate ligands of Formula I: wherein R 1 and R 2 are as defined herein. Also provided are methods and processes of using the iron bisphenolate complexes as catalysts in cross-coupling reactions and in controlled radical polymerizations.

专利号:WO-2013084241-A1
优先权日:2011-12-09
标题:Compounds as inhibitors of renin
发明人：THOMBARE PRAVIN S; DESAI JIGAR N
权利人:CADILA HEALTHCARE LTD; THOMBARE PRAVIN S; DESAI JIGAR N
摘要:The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to processes for preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.