📜Rac-1-(1,3-Dioxoisoindolin-2-yl)Ethyl Acetate置于sodium Hydrogen Sulfate体系中,140.0 °C,3.07 Kpa 条件下,反应生成 N-乙烯基邻苯亚胺 参考文献:Furukawa Et Al.,Kogyo Kagaku Zasshi / Journal Of The Society Of Chemical Industry,1957,Vol. 60,P. 350,352 标题:Furukawa Et Al.,Kogyo Kagaku Zasshi / Journal Of The Society Of Chemical Industry,1957,Vol. 60,P. 350,352
专利号:US-8212077-B2 优先权日:2008-08-05 标 题:Process for the synthesis of agomelatine 发明人:HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE; BARAGNIER NICOLAS 权利人:HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE; BARAGNIER NICOLAS; SERVIER LAB 摘要:Process for the industrial synthesis of the compound of formula (I)
专利号:WO-2011091548-A1 优先权日:2010-01-27 标 题:Method for cucurbitine synthesis 发明人:CHANG XIAOWEI; KHOSHDEL EZAT; PENG WEIMIN; WANG JINFANG; YAO YINFANG 权利人:UNILEVER PLC; UNILEVER NV; UNILEVER HINDUSTAN; CHANG XIAOWEI; KHOSHDEL EZAT; PENG WEIMIN; WANG JINFANG; YAO YINFANG 摘要:A method for the synthesis of cucurbitine comprising the step of forming a pyrrolidine ring by a 1,3 dipolar cycloaddition reaction.
专利号:US-2005080260-A1 优先权日:2003-04-22 标 题 :Preparation of prodrugs for selective drug delivery 发明人:MILLS RANDELL L; WU GUO-ZHANG 摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.
专利号:US-10968173-B2 优先权日:2016-07-07 标题:Thiocarbonylthio compounds as chain transfer agents suitable for raft polymerization 发明人:COCHRAN ERIC W; HERNANDEZ NACU; FORRESTER MICHAEL; HOHMANN AUSTIN 权利人:UNIV IOWA STATE RES FOUND INC 摘要:The present invention relates to a compound having the structure of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as described herein. The present invention also relates to a process for the preparation of a compound of formula (I) and to a process for the synthesis of a polymer using the compound of formula (I) through controlled free radical polymerization.
专利号:US-2020024373-A1 优先权日:2017-03-27 标 题 :Macro-raft chain transfer agents as anionic polymerization terminators 发明人:HERNANDEZ NACU; COCHRAN ERIC; WILLIAMS RONALD CHRISTOPHER; FORRESTER MICHAEL JOHN; BRADLEY WILLIAM; KRAUS GEORGE 权利人:UNIV IOWA STATE RES FOUND INC 摘要:The present invention relates to a compound of Formula (I): where {circle around (P)} R, R 1 , R 2 , R 3 , and Z are as described herein and to a process for preparing a compound of Formula (I). This invention also relates to a process for the synthesis of a polymer which includes providing a monomer composition, providing a compound of Formula (I), and polymerizing monomers within the monomer composition through controlled free radical polymerization with the compound of Formula (I) to form the polymer.
专利号:US-4831159-A 优先权日:1986-06-20 标题 :Process for hydroformylation of n-vinyl-2-pyrrolidinone 发明人:LIN JIANG-JEN 权利人:TEXACO INC 摘要:A process is disclosed for preparing isomeric aldehydes by contacting N-vinyl-2-pyrrolidinone and synthesis gas in the presence of a rhodium-containing compound with or without additional phosphine ligand and a solvent. The alpha and beta isomeric aldehydes such as 2-N-(2-pyrrolionyl)propanaldehyde and 3-N-(2-pyrrolidonyl)propanaldehyde can be converted to 1,2- or 1,3-diaminopropanes via reductive amination or to alcohol amines via reduction.
摘要:Tong, M. L.; Kunz, K.; Jaschinski, M.; Holzschneider, K.; Celik, I. E.; Kirsch, S. F., Science of Synthesis Knowledge Updates, (2020) 2, 239. 摘要:Zhang, M.; Su, W., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 113. 摘要:Andersson, C.-M.; Andersson, M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 8. 摘要:Weimar, M.; Fuchter, M. J., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 159. 摘要:Bronger, R. P. J.; Kamer, P. C. J.; Vogt, D., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 1, 38.