CAS: 3485-84-5; N-Vinylphthalimide

该化合物是一种多用途单体和有机合成的中间体,其特点是其二氟硫化物功能组和反应性氯乙烯协会,其主要优点包括聚合反应中具有高度的回活性,能够形成具有定制特性的专门聚合物,如热稳定性和化学抗药性.该化合物还因其在光阻应用中的实用性以及作为制药和农用化学品的一个构件而受到重视.其坚固的结构确保了各种反应条件下的稳定,使之适合先进的合成过程.N-Vinylphthalimide通常用于学术和工业研究,以开发功能材料和精细化学品.

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上下游产品

CAS号74-86-2 乙炔 | CAS号574-98-1 N-(2-溴乙基)邻苯二甲酰亚胺 | CAS号6674-22-2 1,8-二氮杂双环[5.4.0... | CAS号593-60-2 溴乙烯 | CAS号1074-82-4 邻苯二甲酰亚胺钾盐 | CAS号108-05-4 乙酸乙烯酯 | CAS号65391-10-8 N-phthalimido-D... | CAS号5383-82-4 N-(4-羰苯基)邻苯二甲酰亚胺 | CAS号5022-29-7 N-乙基邻苯二甲酰亚胺 | CAS号2436-29-5 3-邻苯二甲酰亚胺丙醛 | CAS号73365-03-4 2-(1,3-dioxoiso... | CAS号1126518-50-0 (E)-2-(4-acetyl... | CAS号787-69-9 4,4'-二乙酰联苯 | CAS号520-03-6 N-苯基邻苯二甲酰亚胺 | CAS号2736-52-9 2-(1,3-dioxoiso... | CAS号22156-23-6 N-(1-Methoxyeth... | CAS号39739-01-0 2H-Isoindole-2-...

合成工艺路线路线简述

    📜Rac-1-(1,3-Dioxoisoindolin-2-yl)Ethyl Acetate置于sodium Hydrogen Sulfate体系中,140.0 °C,3.07 Kpa 条件下,反应生成 N-乙烯基邻苯亚胺
    参考文献:Furukawa Et Al.,Kogyo Kagaku Zasshi / Journal Of The Society Of Chemical Industry,1957,Vol. 60,P. 350,352
    标题:Furukawa Et Al.,Kogyo Kagaku Zasshi / Journal Of The Society Of Chemical Industry,1957,Vol. 60,P. 350,352

    海关参考信息

    专利信息


    专利号:US-8212077-B2
    优先权日:2008-08-05
    标 题:Process for the synthesis of agomelatine
    发明人:HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE; BARAGNIER NICOLAS
    权利人:HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE; BARAGNIER NICOLAS; SERVIER LAB
    摘要:Process for the industrial synthesis of the compound of formula (I)

    专利号:WO-2011091548-A1
    优先权日:2010-01-27
    标 题:Method for cucurbitine synthesis
    发明人:CHANG XIAOWEI; KHOSHDEL EZAT; PENG WEIMIN; WANG JINFANG; YAO YINFANG
    权利人:UNILEVER PLC; UNILEVER NV; UNILEVER HINDUSTAN; CHANG XIAOWEI; KHOSHDEL EZAT; PENG WEIMIN; WANG JINFANG; YAO YINFANG
    摘要:A method for the synthesis of cucurbitine comprising the step of forming a pyrrolidine ring by a 1,3 dipolar cycloaddition reaction.

    专利号:US-2005080260-A1
    优先权日:2003-04-22
    标 题 :Preparation of prodrugs for selective drug delivery
    发明人:MILLS RANDELL L; WU GUO-ZHANG
    摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

    专利号:US-10968173-B2
    优先权日:2016-07-07
    标题:Thiocarbonylthio compounds as chain transfer agents suitable for raft polymerization
    发明人:COCHRAN ERIC W; HERNANDEZ NACU; FORRESTER MICHAEL; HOHMANN AUSTIN
    权利人:UNIV IOWA STATE RES FOUND INC
    摘要:The present invention relates to a compound having the structure of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as described herein. The present invention also relates to a process for the preparation of a compound of formula (I) and to a process for the synthesis of a polymer using the compound of formula (I) through controlled free radical polymerization.

    专利号:US-2020024373-A1
    优先权日:2017-03-27
    标 题 :Macro-raft chain transfer agents as anionic polymerization terminators
    发明人:HERNANDEZ NACU; COCHRAN ERIC; WILLIAMS RONALD CHRISTOPHER; FORRESTER MICHAEL JOHN; BRADLEY WILLIAM; KRAUS GEORGE
    权利人:UNIV IOWA STATE RES FOUND INC
    摘要:The present invention relates to a compound of Formula (I): where {circle around (P)} R, R 1 , R 2 , R 3 , and Z are as described herein and to a process for preparing a compound of Formula (I). This invention also relates to a process for the synthesis of a polymer which includes providing a monomer composition, providing a compound of Formula (I), and polymerizing monomers within the monomer composition through controlled free radical polymerization with the compound of Formula (I) to form the polymer.

    专利号:US-4831159-A
    优先权日:1986-06-20
    标题 :Process for hydroformylation of n-vinyl-2-pyrrolidinone
    发明人:LIN JIANG-JEN
    权利人:TEXACO INC
    摘要:A process is disclosed for preparing isomeric aldehydes by contacting N-vinyl-2-pyrrolidinone and synthesis gas in the presence of a rhodium-containing compound with or without additional phosphine ligand and a solvent. The alpha and beta isomeric aldehydes such as 2-N-(2-pyrrolionyl)propanaldehyde and 3-N-(2-pyrrolidonyl)propanaldehyde can be converted to 1,2- or 1,3-diaminopropanes via reductive amination or to alcohol amines via reduction.

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    合成参考文献


    摘要:Tong, M. L.; Kunz, K.; Jaschinski, M.; Holzschneider, K.; Celik, I. E.; Kirsch, S. F., Science of Synthesis Knowledge Updates, (2020) 2, 239.
    摘要:Zhang, M.; Su, W., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 113.
    摘要:Andersson, C.-M.; Andersson, M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 8.
    摘要:Weimar, M.; Fuchter, M. J., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 159.
    摘要:Bronger, R. P. J.; Kamer, P. C. J.; Vogt, D., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 1, 38.
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