CAS: 304897-49-2; Tert-Butyl 4-(4-Aminobenzyl)Piperazine-1-Carboxylate

上下游产品

CAS号130636-61-2 4-(4-硝基苯)哌嗪-1-羧酸叔丁酯 | CAS号100-11-8 4-硝基溴化苄 | CAS号57260-71-6 1-B°C-哌嗪 | CAS号58198-49-5 1-[(4-硝基苯基)甲基]哌嗪

📜1-[(4-硝基苯基)甲基]哌嗪置于palladium On Activated Charcoal 氢气,三乙胺体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 4.0H,反应生成 4-(4-氨基苄基)哌嗪-1-羧酸叔丁酯
参考文献:A Novel Series Of 2-Carboxytetrahydroquinolines Provides New Insights Into The Eastern Region Of Glycine Site Nmda Antagonists
标题:A Novel Series Of 2-Carboxytetrahydroquinolines Provides New Insights Into The Eastern Region Of Glycine Site Nmda Antagonists
摘要:A Series Of Potent 4-Substituted Tetrahydroquinolines Has Been Synthesized And Biologically Tested In Order To Refine The Eastern Region Of The Pharmacophore Model For Glycine Site Nmda Antagonists Concerning The Assessment Of Lipophilicity,Flexibility,And Hydrogen Bonding. Displacement Studies On Rat Cortical Membranes Using [3H]-5,7-Dichlorokynurenic Acid As A Radioligand Indicated That Binding Affinities Are Markedly Enhanced When Additional Hydrogen-Accepting Groups Are Introduced Into The Eastern Region Of The 2-Carboxytetrahydroquinolines. Among The Most Potent Ligands Were Some Urea,Sulfonylurea,And Crown Ether Compounds As Interesting Leads For New Diagnostics,Especially For The Evaluation Of Pet Tracers,Which Allow Biodistribution Studies And Nmda Receptor Studies In The Living Organism.
DOI:10.1002/1521-4184(20008)333:8<267::Aid-Ardp267>3.0.Co;2-0