CAS: 2934-97-6; 2,3,9,10-Tetramethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[3,2-A]Isoquinoline

上下游产品

CAS号81701-50-0 5,6,13,13a-tetr... | CAS号75875-59-1 dihydropalmatin... | CAS号104270-87-3 ethyl 6-formyl-... | CAS号120-20-7 3,4-二甲氧基苯乙胺 | CAS号86639-32-9 (+/-)-1-bromote... | CAS号86-51-1 2,3-二甲氧基苯甲醛 | CAS号483-14-7 罗通定 | CAS号4880-79-9 2,3,9,10-tetram...

📜二氢黄藤素置于sodium Tetrahydroborate体系中,用 甲醇 用作溶剂,化学反应 1.0H,反应生成延胡索乙素
参考文献:2,3,9,10-四氧合小oxy碱生物碱及其13-甲基生物碱的便捷合成
标题:2,3,9,10-四氧合小oxy碱生物碱及其13-甲基生物碱的便捷合成
摘要:开发了通过同一中间体合成2,3,9,10-四氧合原小ber碱生物碱及其13-甲基生物碱的新方法.将溴化苄基苯乙胺(13)与α-氯-α-(甲硫基)乙酰氯酰化,然后与氯化锡环化,提供了关键中间体4-甲硫基-3-苯乙基异喹啉-3-酮(14),将其甲基化提供其甲基衍生物(17).异喹啉-3-酮(14,17)都容易以高收率转化为原小ber碱生物碱(16)及其13-甲基生物碱(21).
Doi:10.1248/cpb.48.399

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-11981888-B2
优先权日:2015-03-05
标题 :Synthesis of furans from sugars via keto intermediates
发明人：BINDER JOSEPH B
权利人:BP CORP NORTH AMERICA INC
摘要:The present invention provides a method of preparing a furan derivative comprising the steps of (a) converting a monosaccharide to provide a keto-intermediate product; and (b) dehydrating the keto-intermediate product to provide a furan derivative; wherein the keto-intermediate product is pre-disposed to forming keto-furanose tautomers in solution. The method may further comprise a step of oxidizing the furan derivative to provide a furandicarboxylic acid or a furandicarboxylic acid derivative.

专利号:US-12091696-B2
优先权日:2022-08-10
标 题 :O-methyltransferase protein with highly specific catalytic function for multiple bias parent nuclei and encoding gene and use thereof
发明人：CHEN SHA; YU YUETONG
权利人:INST CHINESE MATERIA MEDICA CHINA ACADEMY OF CMS
摘要:The present disclosure provides an O-methyltransferase protein with a highly specific catalytic function for multiple benzylisoquinoline alkaloids (BIAs) parent nuclei and an encoding gene and use thereof. Compared with wild-type O-methyltransferase, the O-methyltransferase protein (SEQ ID NO: 2) shows an enhanced enzymatic activity and a wider substrate scope. The O-methyltransferase protein can catalyze O-methylation of backbones from three BIAs, including monobenzylisoquinolines (norcoclaurine, coclaurine, and N-methylcoclaurine), aporphines (asimilobine and N-methylasimilobine), and protoberberines (scoulerine and tetrahydrocolumbamine). Meanwhile, this O-methyltransferase protein is highly regioselective for each backbone. The O-methyltransferase protein catalyzes methylation of the monobenzylisoquinolines at 6-OH and 7-OH, is only active on 6-OH of the backbone of the aporphines, and mainly catalyzes methylation of the protoberberines at 2-OH. Moreover, the O-methyltransferase protein has a stronger catalytic activity and can be used as a biocatalyst for the semi-synthesis of related compounds.

专利号:US-8476471-B2
优先权日:2009-07-13
标 题 :Synthesis of prostanoids
发明人：YIANNIKOUROS GEORGE PETROS; KALARITIS PANOS; GAMAGE CHAMINDA PRIYAPUSHPA; ABERNATHY STEPHANIE BOSSE
权利人:YIANNIKOUROS GEORGE PETROS; KALARITIS PANOS; GAMAGE CHAMINDA PRIYAPUSHPA; ABERNATHY STEPHANIE BOSSE; IRIX PHARMACEUTICALS INC
摘要:The presently disclosed subject matter provides a method of synthesizing prostaglandins and prostaglandin analogs comprising the ring closing metathesis of compounds of Formula (I). Also provided are novel compounds of Formula (I) and Formula (II). In addition to their use as synthetic intermediates in the presently disclosed methods, compounds of Formula (II) can be used as prostaglandin and/or prostaglandin analog prodrugs.

专利号:US-5214118-A
优先权日:1990-10-05
标 题:Process for synthesis of polyestercarbonate-siloxane copolymers
发明人：HAWKINS CHRISTOPHER M; ROSENQUIST NILES R
权利人:GEN ELECTRIC
摘要:A process for synthesizing polyestercarbonate-siloxane copolymers which have a smaller concentration of low molecular weight species and greater thermal stability has been described. Essentially the process includes adding the comonomer, diacid chloride siloxane, after approximately 1/3 of the phosgene has been added, in a conventional interfacial copolymerization, (as opposed to addition at the beginning of the polymerization).

专利号:US-10087161-B2
优先权日:2015-08-20
标 题:Synthesis of FDCA and FDCA precursors from gluconic acid derivatives
发明人：KAMBOURAKIS SPIROS; GRIFFIN BENJAMIN M
权利人:SYNTHETIC GENOMICS INC
摘要:The present invention provides methods of method of synthesizing 2,5-furan dicarboxylic acid (FDCA) and FDCA precursor molecules. The methods involve performing a chemical dehydration reaction on a gluconic acid derivative in the presence of a dehydration catalyst. In some embodiments the gluconic acid derivative can be 2-dehydro-3-deoxy gluconic acid (DHG) or an ester thereof, 2-ketogluconic acid (2KGA) or an ester thereof, and 5-ketogluconic acid (5KGA) or an ester thereof. The 2,5-furan dicarboxylic acid precursor molecule is thereby synthesized, which can be converted into FDCA. The chemical dehydration can be performed by a variety of acid basic catalysts.