CAS: 2507-55-3; 2-Hydroxytetradecanoic Acid

相似化合物

617-73-2 5393-81-7 764-67-0

上下游产品

CAS号544-63-8 肉豆蔻酸 | CAS号124-06-1 十四酸乙酯 | CAS号53411-22-6 2-Bromotetradec... | CAS号112-64-1 肉豆蔻酰氯 | CAS号53705-91-2 2-Propyltetrade... | CAS号638-53-9 十三烷酸 | CAS号10486-19-8 十三醛

📜肉豆蔻酸置于双氧水,P450Ja体系中,用 乙醇 用作溶剂,化学反应生成2-羟基肉豆蔻酸
参考文献:P450Jα-一种新的,健壮的,α-选择性脂肪酸羟化酶,显示出意外的1-烯烃形成.
标题:P450Jα-一种新的,健壮的,α-选择性脂肪酸羟化酶,显示出意外的1-烯烃形成.
摘要:脂肪酸的氧基官能化(fas)是设计用于生物基/可生物降解的聚合物,表面活性剂和燃料的新型合成途径的关键步骤.在这里,我们展示了一种稳定的faα-羟化酶(p450Jα)的分离和表征,该酶催化了h 2广泛的fa(c6:0-C16:0)和油酸(c18:1)的选择性转化.O 2作为氧化剂.在优化的反应条件下,P450Jα生成的α-羟基酸均具有> 95%的区域选择性,高比活度(最高15.2 U Mg-1)和氧化剂与产物的有效偶联(最高85%).相对于生产率(ton = 394 Min-1),月桂酸(c12:0)被证明是极好的底物).在制备规模上,以补料分批方式补充h 2 O 2时,C12:0的转化率达到83%(0.9 G L-1).在相似的条件下,P450Jα可以高选择性,高收率(1.1 G L-1;分离产率为79%)进一步实现油酸的首次生物催化α-羟基化(100 Ml规模下88%的转化率)
Doi:10.1002/chem.201905511

专利信息

专利号:US-8835476-B2
优先权日:2005-03-04
标 题:Synthesis of novel antimicrobials
发明人：WU FAN; WEAVER DONALD; BARDEN CHRIS; MCMASTER CHRISTOPHER; BYERS DAVID; HENNEBERRY ANNETTE; BAN FUQIANG
权利人:WU FAN; WEAVER DONALD; BARDEN CHRIS; MCMASTER CHRISTOPHER; BYERS DAVID; HENNEBERRY ANNETTE; BAN FUQIANG
摘要:The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable binding interaction at the active site of the enzyme. In particular, the compounds present the following formula (I) where V, W, X, Y and Z can be independently C, S, N or O and P1, P2 and P3 are ligands to bind to the three points of the proposed pharmacophore model. They can be chosen from a variety of groups.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:US-9034630-B2
优先权日:2009-09-21
标题 :Modified gram-negative bacteria for use as vaccines
发明人：GORVEL JEAN-PIERRE; ARCE GORVEL VILMA; IRIARTE MAITE; MORIYON IGNACIO; CONDE-ALVAREZ RAQUEL
权利人:INST NAT SANTE RECH MED; CT NAT DE LA RECH SCIENTIFIQUE—CNRS; UNIV LA MEDITERRANEE—AIX MARSEILLE II; UNIV NAVARRA; UNIV AIX MARSEILLE
摘要:The invention relates to Gram-negative bacteria carrying an inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said Gram-negative bacteria, wherein said inactivated gene results in the synthesis of a LPS having a modified core. These strains have an attenuated virulence but induce a humoral immunity sufficient for ensuring vaccination of the host.

专利号:EP-0548237-B1
优先权日:1990-09-10
标 题:Method for the production of an article from the Copolymer of Lactide and (e)-Caprolactone for medical applications
发明人：GRIJPMA DIRK WYBE; PENNINGS ALBERT JOHAN
权利人:UNIV GRONINGEN
摘要:The invention relates to a method for the production of an article from a copolymer of lactide and epsilon -caprolactone for medical applications, in which method the copolymer is obtained by a synthesis which is carried out as a bulk synthesis at a temperature of 80 to 160 DEG C. Articles according to the invention can be used in numerous fields, but are in particular advantageous if they are employed in biomedical fields. Examples are an implant for the repair of a meniscus or a blood vessel, stents or artificial skin. Stents are small spirals which are used to hold open (coronary) arteries which have silted up. Use in abdominal wall reconstruction is also possible.

专利号:US-2014256904-A1
优先权日:2011-08-15
标 题:Biotechnological synthesis process of omega-functionalized carbon acids and carbon acid esters from simple carbon sources
发明人：SCHAFFER STEFFEN; DECKER NICOLE; GIELEN JASMIN; HAEGER HARALD; HAAS THOMAS; POETTER MARKUS; HENNEMANN HANS-GEORG; WESSEL MIRJA; VOLLAND MICHAEL
权利人:SCHAFFER STEFFEN; DECKER NICOLE; GIELEN JASMIN; HAEGER HARALD; HAAS THOMAS; POETTER MARKUS; HENNEMANN HANS-GEORG; WESSEL MIRJA; VOLLAND MICHAEL; EVONIK DEGUSSA GMBH
摘要:The subject of the invention is a biotechnological process for the production of ω-functionalized carboxylic acids and of ω-functionalized carboxylate esters from simple carbon sources.