CAS: 2239273-34-6; 3-(2-Amino-6-(1-((6-(2-Hydroxypropan-2-yl)Pyridin-2-yl)Methyl)-1H-1,2,3-Triazol-4-yl)Pyrimidin-4-yl)-2-Methylbenzonitrile

主要参考文献

1: Seifert M, Benmebarek MR, Briukhovetska D, Märkl F, Dörr J, Cadilha BL, Jobst J, Stock S, Andreu-Sanz D, Lorenzini T, Grünmeier R, Oner A, Obeck H, Majed L, Dhoqina D, Feinendegen M, Gottschlich A, Zhang J, Schindler U, Endres S, Kobold S. Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function. Br J Cancer. 2022 Dec;127(12):2175-2185. doi: 10.1038/s41416-022-02013-z. Epub 2022 Oct 20.
2: Claff T, Schlegel JG, Voss JH, Vaaßen VJ, Weiße RH, Cheng RKY, Markovic- Mueller S, Bucher D, Sträter N, Müller CE. Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction. Commun Chem. 2023 Jun 1;6(1):106. doi: 10.1038/s42004-023-00894-6.
3: Franco R, Lillo A, Navarro G, Reyes-Resina I. The adenosine A2A receptor is a therapeutic target in neurological, heart and oncogenic diseases. Expert Opin Ther Targets. 2022 Sep;26(9):791-800. doi: 10.1080/14728222.2022.2136570. Epub 2022 Oct 26.

合成参考文献

参考文献:10.1007/7355_2023_158
摘要:Catarzi D, Varano F, Calenda S, Vigiani E, Colotta V. Once Upon a Time Adenosine and Its Receptors: Historical Survey and Perspectives as Potential Targets for Therapy in Human Diseases. 2023. In: Topics in Medicinal Chemistry.