CAS: 213697-53-1; 2'-(Dicyclohexylphosphino)-N,N-Dimethyl-[1,1'-Biphenyl]-2-Amine

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CAS号694-80-4 2-溴氯苯 | CAS号698-01-1 2-氯-N,N-二甲基苯胺 | CAS号16523-54-9 二环己氯化膦 | CAS号698-00-0 2-溴-N,N-二甲基苯胺 | CAS号931-51-1 环己基氯化镁 | CAS号95-51-2 2-氯苯胺 | CAS号542-18-7 氯代环己烷 | CAS号10282-31-2 4-(4-氰苯基)吗啉 | CAS号476472-48-7 1-(6-methylpyri... | CAS号601513-26-2 2-(2-氯-4-(三氟甲基)苯基)乙酸 | CAS号601513-27-3 2-chloro-4-(tri... | CAS号631909-46-1 1-B°C-5-甲基-6-(4...

环己氯化镁置于magnesium,三氯化磷体系中,用 四氢呋喃,甲苯 用作溶剂,化学反应生成2-二环己膦基-2'-(N,N-二甲胺)-联苯
参考文献:工业规模钯催化的芳基卤化物和胺的偶联反应-个人经历
标题:工业规模钯催化的芳基卤化物和胺的偶联反应-个人经历
摘要:在过去的十年中,胺和芳基卤化物或芳基醇衍生物的钯催化偶联已从奇特的小规模转化发展为非常通用,高效且稳定的反应.本文从工业角度出发报道了该方法的几种应用,包括配体合成,芳基哌嗪,芳基肼和二芳基胺的合成.重点放在扩大规模和安全性问题上,以强调cn联轴器作为解决工业规模综合问题的潜力.
Doi:10.1002/adsc.200505158

专利信息

专利号:US-7205427-B2
优先权日:2002-06-04
标 题:Cross-coupling synthesis of alkyl (dialkylphenyl) indenes
发明人：BARNES HAMLIN H
权利人:BOULDER SCIENT CO
摘要:A cross-coupling synthesis of 2-alkyl-4-(2,6-dialkylphenyl)indenes is described. A 2-alkylidene is treated with a dialkylboronic acid in the presence of a catalyst. A feature of the invention is the use of a cross-coupling catalyst comprising palladium dichloride (1,5-cyclooctadiene) as a cross-coupling catalyst.

专利号:US-7632975-B2
优先权日:2004-12-22
标 题:Process for the synthesis of arylfluorenes and analogs thereof
发明人：HEIDENHAIN SOPHIE
权利人:CDT OXFORD LTD
摘要:A process is provided for the synthesis of a compound of formula (I): n nwherein:n M=0 or 1; N and p are 0 or 1 to 4; X is a single bond, O, S or NH; And R 1 -R 4 are as defined in claim 1.

专利号:US-6958420-B2
优先权日:2002-07-19
标题:Synthesis of aminoarylboronic esters and substituted anilines from arenes via catalytic C-H activation/borylation/amination and uses thereof
发明人：MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL
权利人:UNIV MICHIGAN STATE
摘要:A process is described for synthesizing aminoarylboronic esters of the general formula n n nwherein R, R 2 , and R 3 are each an alkyl, aryl, vinyl, alkoxy, carboxylic esters, amides, or halogen; Ar is any variety of phenyl, naphthyl, anthracyl, heteroaryl; and R 1 is alkyl, hydrogen, or aryl. The aminoarylboronic esters are produced via the metal-catalyzed coupling of arylboronic esters of the general formula n n nwherein R and R 1 are any non-interfering group and X is chloro, bromo, iodo, triflates, or nonaflates to amines (primary and secondary). In particular, a process is described for the synthesis of the aminoarylboronic esters via a step-wise or tandem process in which one catalytic event is a metal-catalyzed borylation and the other catalytic event is a metal-catalyzed amination.

专利号:US-2024336649-A1
优先权日:2021-06-21
标 题 :Synthesis of covalent protein dimers that can inhibit myc-driven transcription
发明人：LOAS ANDREI; PENTELUTE BRADLEY L; POMPLUN SEBASTIAN; JBARA MUHAMMAD; SCHISSEL CARLY KATHERINE; RODRIQUEZ JACOB JOSHUA LEE; BUCHWALD STEPHEN LEFFLER; BOIJA ANN; KLEIN ISAAC; HAWKEN SUSANA WILSON; LI CHARLES HAN
权利人:MASSACHUSETTS INST TECHNOLOGY; WHITEHEAD INSTITUTE OF BIOMEDICAL RES
摘要:The disclosure relates to covalent protein dimers of MYC, MAX, and Omomyc; pharmaceutical compositions comprising the covalent protein dimers; methods of making the covalent protein dimers; and methods of treating disorders associated with MYC dysregulation (e.g., cancer) with the covalent protein dimers.

专利号:US-12049470-B2
优先权日:2021-02-01
标 题 :MK2 inhibitors, the synthesis thereof, and intermediates thereto
发明人：RUCHELMAN ALEXANDER L; COOMBS JOHN R; ZHU KEMING; LIM DANIEL; JOE CANDICE LEE; GEORGE DAVID T; ZHENG BIN; LIN DONG
权利人:CELGENE CORP
摘要:The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.

专利号:US-11718584-B2
优先权日:2019-02-22
标题 :Process for the synthesis anthranilic diamide compounds and intermediates thereof
发明人：KARRI PHANEENDRASAI; PABBA JAGADISH; SHINDE BHARAT UTTAMRAO; KALWAGHE AMOL DNYANESHWAR; MADHAVRAO KAMBLE MARUTI; KLAUSENER ALEXANDER G M; PANMAND DEEPAK SHANKAR
权利人:PI INDUSTRIES LTD
摘要:The present invention disclosed a process for the synthesis of anthranilic diamide compound of formula (I), n n n n n n n n n n wherein, R 1 , R 2 , R 3a , R 3b , R 3c , R 4 , R 5 , R 6 and Z are as defined in the detailed description. The process comprising the step of obtaining a mono- or dicyano substituted aniline compound of formula (IV) which is then converted to an anthranilic acid compound of formula (V) or an anthranilic amide compound of formula (Va). Further, the compound of formula (VI) can be optionally synthesized from compound of formula (IV or V or Va)