专利号:US-7220858-B2 优先权日:2003-12-23 标 题 :Synthesis of hydrazine and chlorinated derivatives of bicyclic pyridazines 发明人:NELSON DEANNA J 权利人:BARBEAU PHARMA INC 摘要:The present invention relates to both a novel method of preparing hydralazine hydrochloride and to a novel method of preparing hydrazine derivatives of compounds containing a pyridazine ring, including, for example, pyridazines, phthalazines and other compounds containing the pyridazine ring.
专利号:WO-2013054302-A1 优先权日:2011-10-12 标 题:Method for preparing triaryl(heteroaryl)bismuths, and uses thereof for the synthesis of aromatic or heteroaromatic derivatives 发明人:CONDON SYLVIE; URGIN KARENE; LEONEL ERIC; AUBE CHRISTOPHE; DUBREUIL DIDIER 权利人:CENTRE NAT RECH SCIENT; UNIV PARIS VAL DE MARNE; UNIV NANTES I; CONDON SYLVIE; URGIN KARENE; LEONEL ERIC; AUBE CHRISTOPHE; DUBREUIL DIDIER 摘要:The invention relates to a method for preparing a derivative of formula (I): (A) 3 -Bi, where the A groups, identical or different, are an aryl or heteroaryl radical, optionally substituted by at least one FG group, which can occupy any position on the aryl or heteroaryl ring, two FG groups occupying the same position where appropriate, FG being an electron-donating group or an electron-withdrawing group on the aryl or heteroaryl radical, by reacting an organozinc compound of formula (II): A-Zn-X, where A is as defined above and X is a halogen, with bismuth trichloride BiCl 3 , which leads to the derivative of formula (I) above. The invention can be used for synthesising bifunctionalised derivatives that can be aromatic or heteroaromatic, optionally halogenated, or polyheteroaromatic.
专利号:US-2005137397-A1 优先权日:2003-12-23 标题:Synthesis of hydrazine derivatives of pyridazine
专利号:US-8257931-B2 优先权日:2005-01-21 标题 :Regulation of protein synthesis 发明人:WAGNER GERHARD; CHOREV MICHAEL; MOERKE NATHAN JOHN; AKTAS BERTAL HUSEYIN; HALPERIN JOSE 权利人:WAGNER GERHARD; CHOREV MICHAEL; MOERKE NATHAN JOHN; AKTAS BERTAL HUSEYIN; HALPERIN JOSE; HARVARD COLLEGE 摘要:A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.
专利号:US-2011021532-A1 优先权日:2008-04-22 标题 :Novel substituted heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase 发明人:POWELL DAVID; LEBRUN MARIE-EVE; BHAT SATHESH; RAMTOHUL YEEMAN K 权利人:MERCK FROSST CANADA LTD 摘要:Substituted heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).
专利号:US-2010144805-A1 优先权日:2005-01-21 标题:Regulation of protein synthesis