CAS: 17639-64-4; 1-Tosyl-1H-Pyrrole

该化合物是有机化合物,其特点是存在一种以聚酰乙烯组(p-toluenesulfonyl group)替代的火花环,该化合物通常呈现一种分子式,反映其结构,既包括来自燃机和硫磺的碳原子和氮原子,也包括来自聚酰乙烯组的氧. 1-环环以其在有机合成中的用途而著称,特别是在形成各种衍生物时,以及作为化学反应的试剂,因为聚酰乙烯组具有电生物特性.该化合物一般在标准实验室条件下保持稳定,但可能会发生典型的热解衍生物(例如电解芳烃替代物)的反应.其溶性可能因溶剂而异,通常在极有机溶剂中更易溶.此外,1-环基螺旋素可以用于合成更复杂的分子,使其在药用化学和材料科学中具有价值.在处理该化合物时,应当注意到安全防范措施,因为许多有机化学品具有潜在的刺激性.

结构式图片

相似化合物

16851-82-4 2051-97-0 5176-27-2

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号109-97-7 吡咯 | CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号696-59-3 2,5-二甲氧基四氢呋喃 | CAS号70-55-3 对甲苯磺酰胺 | CAS号16851-72-2 N-(对甲苯磺酰)-3-吡咯啉 | CAS号290306-56-8 2-溴-1-(对甲苯磺酰基)吡咯 | CAS号1193-62-0 甲基吡咯-2-羧酸酯 | CAS号50487-71-3 N-烯丙基对甲苯磺酰胺 | CAS号129667-02-3 4-环己基-1-(4-甲基苯磺酰基)吲哚 | CAS号129667-10-3 1-甲苯磺酰基-3-(1-萘甲酰基)吡咯 | CAS号129666-99-5 2-乙酰基-1-甲苯磺酰基吡咯 | CAS号106058-85-9 1-(1-甲苯磺酰基-1H-吡... | CAS号16851-72-2 N-(对甲苯磺酰)-3-吡咯啉 | CAS号139261-90-8 3-苯甲酰-1-甲苯磺酰基吡咯 | CAS号123993-98-6 (2R,5R)-2-butyl... | CAS号123994-01-4 cis-2-butyl-5-h... | CAS号89597-62-6 [1-(4-methylphe...

合成工艺路线路线简述

    📜4-甲基-N-(丙-2-炔-1-基)苯-1-磺酰胺置于copper(L) Iodide,二异丙胺,2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 1,4-二氧六环,苯 用作溶剂,化学反应 8.0H,反应生成1-(对甲苯磺酰基)吡咯
    参考文献:用于 3-吡咯啉合成的铜催化多米诺同系化和环异构化反应
    标题:用于 3-吡咯啉合成的铜催化多米诺同系化和环异构化反应
    摘要:发现溴化铜是产生 3-吡咯啉的多米诺反应序列的有效催化剂.Cu(I) 催化炔丙基磺酰胺的 Crabbe 反应和丙二烯中间体的选择性环异构化是使用微波辐射条件进行的,提供了广泛的 2-取代-和 2,5-二取代-3-吡咯啉.反应中间体的机理研究揭示了两种可能的反应途径;两者都提到了乙烯基铜中间体的重要性.
    Doi:10.1002/ejoc.201301621

    海关参考信息

    专利信息


    专利号:WO-2024064745-A1
    优先权日:2022-09-21
    标 题:Synthesis of reldesemtiv
    发明人：PETERSON MATTHEW W; LU QING; MORGAN BRADLEY P; ASHCRAFT LUKE W; ANDERSEN DENISE
    权利人:CYTOKINETICS INC
    摘要:Provided herein is a process for the preparation of reldesemtiv and salts thereof. Also provided herein are intermediates used in this process and their preparation.

    专利号:US-10836774-B2
    优先权日:2016-11-30
    标题 :Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds
    发明人：LINDSEY JONATHAN S; ZHANG SHAOFEI
    权利人:UNIV NORTH CAROLINA STATE
    摘要:Described herein are bacteriochlorins comprising an annulated isocyclic ring such as a compound Formula I: n nor a metal conjugate thereof, wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , and Z are each as defined herein. Also described are methods and intermediates for the synthesis of bacteriochlorins comprising an annulated isocyclic ring, and methods of using such bacteriochlorins for, among other things, diagnostic and therapeutic purposes such as, e.g., luminescent compounds in flow cytometry, and/or as active agents in photodynamic therapy (PDT).

    专利号:WO-2015088564-A1
    优先权日:2013-12-13
    标 题:P2x4 receptor modulating compounds
    发明人：NEWCOM JASON S; SPEAR KERRY L
    权利人:SUNOVION PHARMACEUTICALS INC
    摘要:Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:A Facile Synthesis Of N-Substituted Pyrroles
    作者:Y. Fang,D. Leysen,H. C. J. Ottenheijm |发布日期:1995.6
    摘要:Abstract Phosphorous Pentoxide Is The Catalyst Of Choice For The Facile Conversion Of Primary Amines, Aromatic Amines, Sulfonamides And Primary Amides Into The Corresponding N-Substituted Pyrroles From 2,5-Dimethoxytetrahydrofuran.

    合成参考文献


    摘要:Lubell, W. D.; St-Cyr, D. J.; Dufour-Gallant, J.; Hopewell, R.; Boutard, N.; Kassem, T.; Dörr, A.; Zelli, R., Science of Synthesis Knowledge Updates, (2013) 1, 316.
    摘要:Lubell, W. D.; St-Cyr, D. J.; Dufour-Gallant, J.; Hopewell, R.; Boutard, N.; Kassem, T.; Dörr, A.; Zelli, R., Science of Synthesis Knowledge Updates, (2013) 1, 288.
    摘要:Gaspar, B.; Trauner, D., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 391.
    摘要:Nakao, Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 436.
    摘要:Sambiagio, C.; Maes, B. U. W., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 147.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知