CAS: 156275-96-6; Triisopropylsilanethiol

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CAS号6485-79-6 三异丙基硅烷 | CAS号13154-24-0 三异丙基氯硅烷

三异丙基硅烷置于sulfur体系中,化学反应生成三异丙基硅烷硫醇
参考文献:A Divergent Synthesis Of Oligoarylalkanethiols With Lewis-Basic N-Donor Termini
标题:A Divergent Synthesis Of Oligoarylalkanethiols With Lewis-Basic N-Donor Termini
摘要:脂肪族硫醇是形成具有高长程有序性的自组装单层的重要分子.如果这些单层要作为其他分子的附着基础,相应的硫醇需要携带合适的功能团,如氨基或吡啶基.由于这些功能团具有路易斯碱性,因此在大多数反应条件下,它们与硫醇基不兼容.本文展示了一种进入这一多功能化合物类别的方法,通过使用基础构建块,其中的硫醇基被三异丙基硅基硫化物保护,使其与许多试剂(包括格氏试剂和钯催化剂)兼容.借助这一策略,六种具有双苯基和三苯基骨架的硫醇,带有一至三个亚甲基基团,以及氨基或吡啶头基,可以通过简短的反应序列获得.
Doi:10.1039/c003795H

专利信息

专利号:US-11642335-B2
优先权日:2019-09-26
标题 :Chemical synthesis of clopidogrel active metabolites and disulfide conjugate prodrugs
发明人：ZHU YAOQIU
权利人:UNIV TEXAS
摘要:A method of synthesizing a clopidogrel metabolite is provided. A piperidone intermediate is formed from a mandelate. An asymmetric ketone reduction of the piperidone intermediate is performed. A mercapto installation is performed on the piperidone intermediate to form a clopidogrel metabolite that includes a 4-carbon chiral center having an (R) configuration.

专利号:US-9453102-B2
优先权日:2013-10-18
标题:Synthesis of chalcogen-capped pi-conjugated polymers
发明人：LUSCOMBE CHRISTINE KEIKO; OKAMOTO KEN
权利人:UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
摘要:Methods for the preparation of mono- and bis-end-functionalized Ï€-conjugated polymers. In the methods, chalcogens are selectively installed at the polymer terminus or termini.

专利号:US-12291547-B2
优先权日:2019-06-14
标题 :Synthesis of 3-azido-3-deoxy-D-galactopyranose
发明人：GIGUÈRE DENIS; ST-GELAIS JACOB; DENAVIT VINCENT
权利人:UNIV LAVAL
摘要:The present application provides a synthetic method for production of 3-azido-3-deoxy-D-galactopyranose. Also provided are methods of using the 3-azido-3-deoxy-D-galactopyranose in the manufacture of galactoside galectin antagonists, such as TD139 (GB0139), GB1107, GB2064, and GB1211.

专利号:US-6372906-B1
优先权日:2001-04-12
标 题 :Synthesis of silyl camptothecins and silyl homocamptothecins
发明人：CURRAN DENNIS P; DU WU
权利人:UNIV PITTSBURGH
摘要:A method of synthesizing 7-silyl camptothecins and 7-silyl homocamptothecins includes the step of mixing a camptothecin or a homocamptothecin having hydrogen at the C7 position with a silyl radical generator and a silyl radical precursor under conditions to generate a silyl radical. SiR 1 R 2 R 3 wherein R 1 , R 2 and R 3 are independently a C 1-10 alkyl group, a C 2-10 alkenyl group, a C 2-10 alkynyl group, an aryl group, —(CH 2 ) m R 11 or SiR 12 R 13 R 14 , wherein m is an integer within the range of 1 through 10 and R 11 is a hydroxy group, an alkoxy group, an amino group, an alkylamino group, a dialkylamino group, F, Cl, a cyano group, —SR c or a nitro group, and wherein R 12 , R 13 and R 14 are independently the same or different an alkyl group or an aryl group.

专利号:US-2022251132-A1
优先权日:2019-06-24
标 题 :Large scale process of 3,3'-dideoxy-3,3'-bis-[4-(3-fluorophenyl)-1h-1,2,3-triazol-1-yl]-1,1'-sulfanediyl-di-beta-d-galactopyranoside
发明人：ZETTERBERG FREDRIK; TYRELL ANDREW; NILSSON ULF; BERGH ANDERS; CUMMINS JONATHAN; WEYMOUTH-WILSON ALEXANDER; CLARKSON ROBERT
权利人:GALECTO BIOTECH AB
摘要:The present invention relates to a process for preparing a compound of formula (I) n n n n n n n n n n wherein said process is suitable for large scale synthesis.

专利号:US-2023201182-A1
优先权日:2019-09-26
标题:Chemical synthesis of clopidogrel active metabolites and disulfide conjugate prodrugs