CAS: 15115-59-0; 4-Chloro-2,3-Dihydroinden-1-One

相似化合物

52397-81-6 52977-63-6 34911-25-6

上下游产品

2-Bromo-4-Chloro-2,3-Dihydro-1H-Inden-1-One 3199-69-7

4-氨基茚酮置于盐酸,Copper(L) Chloride,Sodium Nitrite体系中,用 水 用作溶剂,化学反应 2.0H,以63%的收率获得4-氯-1-茚满酮
参考文献:Tricyclic Pyrazoles. Part 1: Synthesis And Biological Evaluation Of Novel 1,4-Dihydroindeno[1,2-C]Pyrazol-Based Ligands For Cb1And Cb2 Cannabinoid Receptors
标题:Tricyclic Pyrazoles. Part 1: Synthesis And Biological Evaluation Of Novel 1,4-Dihydroindeno[1,2-C]Pyrazol-Based Ligands For Cb1And Cb2 Cannabinoid Receptors
摘要:Cannabinoids Receptors,Cellular Elements Of The Endocannabinoid System,Have Been The Focus Of Extensive Studies Because Of Their Potential Functional Role In Several Important Physiological And Pathological Processes. To Further Evaluate The Properties Of Cb Receptors,Especially Cb1 And Cb2 Subtypes,We Have Designed,Using Sr141716A As A Benchmark,A New Series Of Rigid 1-Aryl-1,4-Dihydroindeno[1,2-C]Pyrazole-3-Carboxamides. Compounds I Were Synthesized From Substituted 1-Aryl-1,4-Dihydroindeno[1,2-C]Pyrazole-3-Carboxylic Acids And Requisite Amines. The Various Analogues Were Assayed For Binding Both To The Brain And Peripheral Cannabinoid Receptors (Cb1 And Cb2). Seven Of The New Compounds Displayed Very High In Vitro Cb2 Binding Affinities,Especially 1A,1B,1C,1E,1G,1H And 1J Which Showed K-I Values Of 0.34,0.225,0.27,0.23,0.385,0.037 And 0.9 Nm,Respectively. Compounds 1A,1B,1C And 1H Showed The Highest Selectivity For Cb2 Receptor With K-I(Cb1) To K-I(Cb2) Ratios Of 6029,5635,5814 And 9810,Respectively. Noticeably,1H Exhibited The Highest Affinity And Selectivity For Cb2 Receptors. (C) 2002 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0968-0896(02)00319-X

专利信息

专利号:CN-116283657-A
优先权日:2023-02-22
标题 :A kind of indanone derivative and its synthesis method and application