专利号:US-6600029-B1 优先权日:1995-12-19 标题:Metabolic engineering of polyhydroxyalkanoate monomer synthases 发明人:SHERMAN DAVID H; WILLIAMS MARK D; XUE YONGQUAN 权利人:UNIV MINNESOTA 摘要:A novel pathway for the synthesis of polyhydroxyalkanoate is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalknoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalknoate synthase.
专利号:US-2003194784-A1 优先权日:2001-04-17 标题:DNA encoding methymycin and pikromycin 发明人:SHERMAN DAVID H; LIU HUNG-WEN; XUE YONGQUAN; ZHAO LISHAN 摘要:A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.
专利号:US-6265202-B1 优先权日:1998-06-26 标 题 :DNA encoding methymycin and pikromycin 发明人:SHERMAN DAVID H; LIU HUNG-WEN; XUE YONGQUAN; ZHAO LISHAN 权利人:UNIV MINNESOTA 摘要:A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.
专利号:US-7947736-B2 优先权日:2004-07-16 标 题:Oligomeric compounds 发明人:GROSS RICHARD A 权利人:BTG INT LTD 摘要:Method for the synthesis of a compound of formula H(OCH[CH 3 ]CH 2 C[O]) 3 —O-A-O—R wherein A is the residue of 1,3-butandiol and R is H or H(OCH[CH 3 ]CH 2 C[O] 3 —. The method comprises reacting a cyclic oligomer of (R)-3-hydroxybutyrate consisting of (R)-3-hydroxybutyrate moieties with a 1,3-butandiol in an organic solvent in the presence of Candida antarctica lipase type B in a furan or pyran solvent.
专利号:US-9260734-B2 优先权日:2000-03-02 标题:Sphingomonas strains producing greatly increased yield of PHB-deficient sphingan (diutan) 发明人:HARDING NANCY E; TALASHEK TODD A; PATEL YAMINI N 权利人:HARDING NANCY E; TALASHEK TODD A; PATEL YAMINI N; CP KELCO US INC 摘要:PHB-deficient Sphingomonas strains having improved sphingan yield are provided. Certain of the Sphingomonas strains are diutan-producing strains that exhibit a dramatic improvement in productivity and yield due to a combination of certain genetic modifications that affect PHB and sphingan synthesis. Moreover, the sphingans produced from such strains have superior characteristics including improved filterability, clarity, and improved rheology-modifying characteristics. The sphingans provided are, thus, highly desirable in a variety of commercial and industrial uses, including personal care items, cement applications, and oilfield applications.
专利号:EP-1778213-B1 优先权日:2004-07-16 标 题 :A method for the synthesis of oligomeric compounds
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