CAS: 147266-92-0; (2R,4S)-1-(Tert-Butoxycarbonyl)-4-Hydroxypyrrolidine-2-Carboxylic Acid

相似化合物

87691-27-8 135042-12-5 102195-79-9

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号51-35-4 L-羟脯氨酸 | CAS号3398-22-9 反式-4-羟基-D-脯氨酸 | CAS号862996-26-7 (2R)-N-B°C-tran... | CAS号77450-00-1 (2R,4R)-4-hydro... | CAS号1208237-83-5 (2R)-2-amino-3-... | CAS号77450-03-4 (2R,4S)-4-羟基-2-...

N-α-Tert-Butyloxycarbonyl-Cis-4-Hydroxy-D-Proline Ethyl Ester置于sodium Hydroxide,三苯基膦,偶氮二甲酸二乙酯体系中,用 四氢呋喃,水,甲苯 用作溶剂,化学反应 3.0H,反应生成N-Boc-反式-4-羟基-D-脯氨酸
参考文献:脯氨酸吡咯烷环锁定构象的合成和构象分析的顺式和反式-4-叔-Butylprolines
标题:脯氨酸吡咯烷环锁定构象的合成和构象分析的顺式和反式-4-叔-Butylprolines
摘要:脯氨酸吡咯烷环的运动限制使得该仲胺氨基酸可以在许多肽和蛋白质中充当转向诱导剂.已知吡咯烷环具有两个主要的褶皱模式(即c-4(cγ)exo和内包膜构象异构体,其比例可通过环中适当的取代基控制).在自然界中,Exo褶皱的4(R)-羟基-1-脯氨酸在胶原蛋白和类似胶原蛋白的结构中起着至关重要的作用.先前已经得出结论,4-顺式取代基的电负性增加了内褶皱,而4-反式取代基的电负性有利于内缩.Exo皱褶.在这里,我们在c-4处以反式和顺式构型引入了一个空间上需要的叔丁基.反式的情况下-取代,所述吡咯烷环上的感应起皱效果用x射线晶体学研究和1次1 H NMR光谱的模拟.两个顺式-和反式-4-叔丁基团强烈支持pseudoequatorial取向,由此导致为吡咯烷环,相反皱纹效果顺-外和反式-内切为升-脯氨酸,与在负电c-4取代基的情况下观测到的效果相反.给出了构象受限的4-叔丁基脯氨酸的合成和结构分析.脯氨酸由4-羟基-1-脯氨酸合成,用t
Doi:10.1021/jo050838A

专利信息

专利号:US-2022298204-A1
优先权日:2019-07-05
标题 :Synthesis of a-amanitin and its derivatives
发明人：SIEGERT MARY-ANN; KNITTEL CAROLINE HERTA; SÃœSSMUTH RODERICH
权利人:PURE BIOORGANICS SIA
摘要:The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.

专利号:EP-3792250-A1
优先权日:2019-09-13
标题:Synthesis of alpha-amanitin and its derivatives
发明人：SIEGERT MARY-ANN; KNITTEL CAROLINE HERTA; SÃœSSMUTH RODERICH
权利人:PURE BIOORGANICS SIA
摘要:The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.

专利号:US-8927739-B2
优先权日:2011-05-18
标 题 :Processes for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives
发明人：QIU YAO-LING; PENG XIAOWEN; KIM IN JONG; CAO HUI; TANG DATONG; OR YAT SUN; WANG GUOQIANG; XU GUOYOU
权利人:ENANTA PHARM INC
摘要:The present invention relates generally to an improved process for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives which are useful intermediates in the synthesis of biologically active molecules, especially in the synthesis of hepatits C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (Ia), (Ib) and (Ic):

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:CN-114080395-A
优先权日:2019-07-05
标 题:Synthesis method of alpha-amanitine and derivatives thereof