CAS: 130753-13-8; Benzyl 3-Oxo-8-Azabicyclo[3.2.1]Octane-8-Carboxylate

该化合物是一种属于Tropinones类的化合物,是Tropine的衍生物,其特点是:存在一种碳苯基(Cbz)保护组,可增强有机溶剂的稳定性和溶解性;该组通常显示一种白色到非白色的晶体外观,在各种有机溶剂中溶解,使其适合用于有机合成和药用化学.N-Cbz-Nortropinone由于结构特征,经常被用作各种药物和生物活性化合物合成的中间体,可进一步发挥功能;其再活动受到可参与核分裂性附加反应的氯酮功能组的影响.此外,Cbz组的存在可促进选择性反应,使其成为合成有机化学中有价值的建筑块.与许多化学物质一样,应观察适当的处理和安全防范措施,因为其使用可能带来危害.

英文名称Benzyl 3-Oxo-8-Azabicyclo[3.2.1]Octane-8-Carboxylate
中文名称N-Cbz-去甲托品酮
IUPAC名称benzyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate
其它别名3-氧代-8-氮杂双环[3,2,1]辛-8-羧酸苄酯; N-Cbz-Notropinone
CAS编号130753-13-8
MFCD编号:MFCD07776632
EINECS号:871-108-0
分子式:C15H17NO3
分子量:259.3
产品CID: 466866
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: RMIQGRJJCNFRRU-UHFFFAOYNA-N
InChI=1S/C15H17NO3/c17-14-8-12-6-7-13(9-14)16(12)15(18)19-10-11-4-2-1-3-5-11/h1-5,12-13H,6-10H2…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数2.0

相似化合物

185099-67-6 25602-68-0 28957-72-4

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

3-oxo-8-azabicyclo[3.2.1]°Ctane hydr°Chloride benzyl chloroformate nortropinone benzyl 3-hydroxy-8-azabicyclo[3.2.1]°Ctane-8-carboxylate°Ct-2-ene-8-carboxylatebenzyl (1S,5R)-(-)-3-trimethylsiloxy-8-azabicyclo3.2.1°Ct-2-ene-8-carboxylate H-indol-3-yl)-8-aza-bicyclo[3.2.1]°Ct-2-ene-8-carboxylic acid benzyl ester3-(1H-indol-3-yl)-8-aza-bicyclo[3.2.1]°Ct-2-ene-8-carboxylic acid benzyl ester methyl (2R,5S)-(-)-1-benzyloxycarbonyl-5-hydroxymethylpyrrolidin-2-ylethanoate benzyl (2S,5S)-2-but-1-enyl-5-pent-4-enylpyrrolidine-1-carboxylate

合成工艺路线路线简述

合成目标产物 N-Cbz-Nortropinone 主要起始原料 Nortropinone Hydrochloride And Benzyl Chloroformate
(文献来源)合成步骤主要原料 Nortropinone Hydrochloride 和 Benzyl Chloroformate

1,3-丙酮二羧酸置于asca-2 盐酸,氢气,碳酸氢钠,溶剂黄146体系中,用四氢呋喃,水用作溶剂,80.0 °C,101.33 Kpa 条件下,反应 22.0H,反应生成N-Cbz-去甲托品酮
参考文献:Ep2009006
标题:Ep2009006

海关参考信息

2902300000-甲苯
2906210000-苄醇
2912110000-甲醛
2912120000-乙醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2012203004-A1
优先权日:2009-08-13
标题 :process for the synthesis of alkyl/aralkyl (2s)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof: key intermediates for the preparation of dppiv inhibitors
发明人：ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA
权利人:ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA; LUPIN LTD
摘要:An improved process for the synthesis of intermediates like Alkyl/Aralkyl (2S)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof which are useful in the synthesis of Dipeptidyl peptidase-IV (DP-PIV) inhibitors.

专利号:WO-2011018796-A1
优先权日:2009-08-13
标题 :An improved process for the synthesis of alkyl/aralkyl (2s)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof: key intermediates for the preparation of dppiv inhibitors