CAS: 100-16-3; 4-Nitrophenylhydrazine

上下游产品

4-nitrobenzenediazonium chloride 4-nitro-aniline triphenylphosphine p-nitrophenylazobenzenethiosulfonate 2-(4-nitrophenyl)thiophene tetrahydro-furan-2-carbaldehyde-(4-nitro-phenylhydrazone) syn-(pyridine-4-aldehyde-4-nitrophenylhydrazone) 3-pyridinealdehyde 4-nitrophenylhydrazone

对氟硝基苯置于一水合肼体系中,用 乙醇 用作溶剂,以19 %的收率获得4-硝基苯肼
参考文献:化学蛋白质组学揭示 Mrsa 中恶二唑酮的抗生素靶标
标题:化学蛋白质组学揭示 Mrsa 中恶二唑酮的抗生素靶标
摘要:表型筛选是鉴定新型抗生素的有效方法,但对于具有多药理学作用模式的化合物,阐明负责抗菌活性的靶点通常具有挑战性.在这里,我们展示了基于活性的蛋白质分析绘制了一系列 1,3,4-Oxadiazole-3-Ones 的靶标相互作用图谱,这些 1,3,4-Oxadiazole-3-Ones 在表型筛选中被鉴定为对多重耐药金黄色葡萄球菌具有高抗菌效力. 原位竞争和比较化学蛋白质组学与定制的基于活性的探针,结合转座子和抗性研究,揭示了几种半胱氨酸和丝氨酸水解酶作为相关目标.我们的数据显示恶二唑酮是一种新型抗菌化学型,具有多药理学作用模式,其中 Fabh,Fphc 和 Adhe 起着核心作用.
Doi:10.1021/jacs.2C10819

专利信息

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:US-12102615-B2
优先权日:2018-04-05
标 题:Synthesis of novel xylose free occidiofungin analogues and methods of using them
发明人：SMITH JAMES L; GENG MENGXIN; RAVICHANDRAN AKSHAYA; ORUGUNTY RAVI
权利人:TEXAS A & M UNIV SYS; SANO CHEMICALS
摘要:The subject invention pertains to methods for producing novel occidiofungin analogues lacking xylose (OF-Δxyl analogue). OF-Δxyl analogues can contain aldehyde, amine, triazole, or hydrazones. The aldehyde, amine, triazole or hydrazone containing analogues of OF-Δxyl can be further modified by substitution with additional functional groups. Various OF-Δxyl analogues described herein have reduced inflammation and toxicity and superior pharmacological properties compared to the natural occidiofungins. Accordingly, certain embodiments of the invention provide methods of treating or preventing fungal infections by administering to the subjects in need thereof the OF-Δxyl analogues described herein.

专利号:US-5877296-A
优先权日:1994-06-03
标题:Process for preparing conjugates of methyltrithio antitumor agents
发明人：HAMANN PHILIP ROSS; HINMAN LOIS; HOLLANDER IRWIN
权利人:AMERICAN CYANAMID CO
摘要:This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

专利号:US-5233044-A
优先权日:1989-06-08
标题:Active esters for solid phase peptide synthesis
发明人：HUDSON DEREK
权利人:MILLIPORE CORP
摘要:Derivatives of 1-phenyl pyrazolin-5-one have many applications for biomolecule synthesis. Enol esters of protected amino acids made by the present process provide efficient coupling in solid-phase peptide synthesis. The 1-phenyl-pyrazolin-5-one derivatives are highly crystalline, stable, non-toxic and easy to prepare. Many possess self-indicating properties, facilitating spectrophotometric monitoring and automation of peptide synthesis.

专利号:EP-0401797-A1
优先权日:1989-06-08
标 题:Active esters for solid phase peptide synthesis
发明人：HUDSON DEREK
权利人:MILLIPORE CORP
摘要:Derivatives of 1-phenyl pyrazolin-5-one have many applications for biomolecule synthesis. Enol esters of protected amino acids made by the present process provide efficient coupling in solid-phase peptide synthesis. The 1-phenyl-pyrazolin-5-one derivatives are highly crystal­line, stable, non-toxic and easy to prepare. Many possess self-indicating properties, facilitating spectro­photometric monitoring and automation of peptide synthesis.

专利号:US-7186709-B2
优先权日:2002-08-27
标 题:Dihydropyrancarboxamides and uses thereof
发明人：SCHREIBER STUART L; STAVENGER ROBERT A; MITCHISON TIMOTHY J; MALIGA ZOLTAN
权利人:HARVARD COLLEGE
摘要:The present invention provides novel dihydropyrancarboxamide compounds of formula (I): n nand collections of these compounds, and provides methods for the synthesis of these compounds; wherein R 1 –R 6 are as defined herein. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as proliferative diseases, and cancer, to name a few.