CAS: 95-47-6; O-Xylene

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CAS号615-60-1 4-氯-1,2-二甲基苯 | CAS号608-23-1 3-氯邻二甲苯 | CAS号67-56-1 甲醇 | CAS号108-88-3 甲苯 | CAS号201230-82-2 carbon monoxide | CAS号612-14-6 邻苯二甲醇 | CAS号71-43-2 苯 | CAS号108-38-3 间二甲苯 | CAS号7341-24-4 2-甲基苄基硫醇 | CAS号100-41-4 乙苯 | CAS号1079-15-8 1,2,3,4-tetrach... | CAS号1006-32-2 1,2,3,4-tetrach... | CAS号1076-61-5 6,7-Dimethyltetralin | CAS号105174-63-8 3-bromo-1-(3,4-... | CAS号4920-95-0 3,3',4,4'-四甲基联苯 | CAS号5006-39-3 1-(3,4-dimethyl... | CAS号529-19-1 邻甲基苯腈 | CAS号529-20-4 邻甲基苯甲醛 | CAS号527-85-5 2-甲基苯甲酰胺 | CAS号527-61-7 2,6-二甲基对苯醌

Cantharidin置于tetraphosphorus Decasulfide体系中,化学反应生成 邻二甲苯
参考文献:Piccard,Chemische Berichte,1879,Vol. 12,P. 577
标题:Piccard,Chemische Berichte,1879,Vol. 12,P. 577

专利信息

专利号:US-10189803-B2
优先权日:2008-02-22
标题 :Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN SOON; ILLINOIS INSTITUTE OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:WO-2021014395-A1
优先权日:2019-07-24
标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs
发明人：ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT
权利人:DR REDDY’S INST OF LIFE SCIENCES
摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.

专利号:US-8350031-B2
优先权日:2008-06-02
标 题:Processes for the synthesis of levocetirizine and intermediates for use therein
发明人：RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
权利人:CIPLA LTD; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
摘要:The present invention provides a compound of formula (IV) n nwherein R is Cl, Br, NO 2 , OH or OR′, and R′ is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (−)-1-[(4-chlorophenyl)-phenylmethyl]piperazine, an intermediate useful in the synthesis of levocetirizine. The present invention also provides compounds (II) and (III) which are useful in the synthesis of compound (IV).

专利号:US-5118853-A
优先权日:1988-10-13
标题:Processes for the synthesis of 3-disubstituted aminoacroleins
发明人：LEE GEORGE T; REPIC OLJAN
权利人:SANDOZ LTD
摘要:Process for the synthesis of compounds of the formula ##STR1## comprising the steps of (i) reacting a compound of the formula ##STR2## with oxalyl chloride or oxalyl bromide to form the corresponding compound of the formula ##STR3## (ii) reacting said compound of the formula ##STR4## with a compound of the formula ##STR5## to form the corresponding compound of the formula ##STR6## (iii) hydrolyzing said compound of the formula ##STR7## to obtain the corresponding compound of the formula ##STR8## the use of the compounds of the formula ##STR9## for the synthesis of the compounds of the formula ##STR10## and the use of the intermediates of Formula VII for the direct synthesis of the compounds of Formula II, n wherein n R 1 is C 1-3 alkyl, phenyl or phenyl substituted by 1 to 3 substituents each of which is independently C 1-3 alkyl, C 1-3 alkoxy, fluoro, chloro, bromo or nitro (maximum of two nitro groups), n R 1b is phenyl or phenyl substituted by 1 to 3 substituents each of which is independently C 1-3 alkyl, C 1-3 alkoxy, fluoro, chloro, bromo or nitro (maximum of two nitro groups), n R 2 is C 1-3 alkyl, n one of R 3 and R 4 is ##STR11## and the other is primary or secondary C 1-6 alkyl not containing an asymmetric carbon atom, C 3-6 cycloalkyl or phenyl-(CH 2 ) m -, n wherein n R 7 is hydrogen, C 1-3 alkyl, n-butyl, i-butyl, t-butyl, C 1-3 alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, n R 8 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, n R 9 is hydrogen, C 1-2 alkyl, C 1-2 alkoxy, fluoro or chloro, and n m is 1, 2 or 3, with the provisos that not more than one of R 7 and R 8 is trifluoromethyl, not more than one of R 7 and R 8 is phenoxy, and not more than one of R 7 and R 8 is benzyloxy, n R 5 is hydrogen, C 1-3 alkyl, n-butyl, i-butyl, t-butyl, C 3-6 cycloalkyl, C 1-3 alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, and n R 6 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, trifluoromethyl, fluoro, chloro, phenoxy, or benzyloxy, with the provisos that not more than one of R 5 and R 6 is trifluoromethyl, not more than one of R 5 and R 6 is phenoxy, and not more than one of R 5 and R 6 is benzyloxy, n R 10 is C 1-6 alkyl, each X is chloro or bromo, and each X.sup.⊖ is chloride or bromide.

专利号:WO-9312076-A1
优先权日:1991-12-13
标题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS ROY
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-8273790-B2
优先权日:2005-01-14
标 题:Exo-selective synthesis of himbacine analogs
发明人：THIRUVENGADAM TIRUVETTIPURAM K; SUDHAKAR ANANTHA; LIM NGIAP KIE; KWOK DAW-IONG; WU GEORGE G; WANG TAO; HUANG MINGSHENG; GREEN MICHAEL D
权利人:THIRUVENGADAM TIRUVETTIPURAM K; SUDHAKAR ANANTHA; LIM NGIAP KIE; KWOK DAW-IONG; WU GEORGE G; WANG TAO; HUANG MINGSHENG; GREEN MICHAEL D; SCHERING CORP
摘要:This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence: