CAS: 93-99-2; Phenyl Benzoate

该化合物是苯酚和苯甲酸凝聚形成的芳香酯,看起来像是熔点为68-70°C的白色晶状固体,在水中溶解,但易溶解,易溶于乙醇和乙醚等有机溶剂中.该化合物主要用作有机合成的中间体,特别是在生产药品,香料和液晶材料方面.在中度条件下和定义明确的再活动下,该化合物的稳定性使它成为重要的蒸发和转发反应剂.由于苯甲酸酯能够有效吸收紫外光,它在某些聚合物应用中也起到UV吸收作用.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

欧盟化妆品法规附录五-准用防腐剂清单ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

bis(phenyl) carbonate benzophenone sodium benzoate phosphoric acid triphenyl esterN-(pyrimidin-2'-yl)benzamide triphenyldiketone N-(4-methylthiazol-2-yl)benzamide ethyl 2,2-dimethyl-3-oxo-3-phenylpropionate

合成工艺路线路线简述

  • 959-22-8 = 93-99-2
    反应条件:1.1 Catalysts: Potassium Carbonate Solvents: 1,4-Dioxane; 48 H,120 °C
    标题:Transesterification Of (Hetero)Aryl Esters With Phenols By An Earth-Abundant Metal Catalyst
    作者:Chen,Jianxia; Namila,E.; Bai,Chaolumen; Baiyin,Menghe; Bao,Agula; Et Al
    参考文献:Rsc Advances 日期:2018 卷标:8(44) 页码:25168-25176]

    1523-15-5 = 93-99-2
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 30 Min,20 °C
    标题:Enthalpy And Entropy Relations In Reactions Of 2,4-Dinitrophenyl Benzoate With Phenols In The Presence Of Potassium Carbonate In Dimethylformamide
    作者:Khalfina,I. A.; Vlasov,V. M.
    参考文献:Russian Journal Of Organic Chemistry 日期:2008 卷标:44(11) 页码:1619-1625]

    591-50-4 = 93-99-2
    反应条件:1.1 Reagents: Potassium Hydroxide Catalysts: Palladium (Merrifield Resin-Supported Bisoxazoline Complexes),3′,4′-Bis(4,5-Dihydro-4,4-Dimethyl-2-Oxazolyl)[1,1′-Biphenyl]-4-Ol (Palladium Complexes,Merrifield Resin-Supported) Solvents: Acetonitrile; 100 Psi,Rt -> 120 °C; 6 H,120 °C
    标题:A Palladium-Bisoxazoline Supported Catalyst For Selective Synthesis Of Aryl Esters And Aryl Amides Via Carbonylative Coupling Reactions
    作者:Ibrahim,Mansur B.; Suleiman,Rami; Fettouhi,Mohammed; El Ali,Bassam
    参考文献:Rsc Advances 日期:2016 卷标:6(82) 页码:78826-78837]

    102-09-0 + 93-97-0 = 93-99-2
    反应条件:1.1 Reagents: Anisole Catalysts: 4-(Dimethylamino)Pyridine; 3 H,110 °C
    标题:Manufacture Of (Meth)Acrylic Acid Ester And Aromatic Carboxylic Acid Ester
    参考文献:World Intellectual Property Organization]

    17763-67-6 + 1864-94-4 = 93-99-2
    反应条件:1.1 Reagents: Triethylamine Catalysts: Palladium Diacetate,1,1′-(9,9-Dimethyl-9H-Xanthene-4,5-Diyl)Bis[1,1-Diphenylphosphine] Solvents: Acetonitrile; 15 - 20 H,80 °C
    标题:Palladium-Catalyzed Carbonylation Of Aryl,Alkenyl,And Allyl Halides With Phenyl Formate
    作者:Ueda,Tsuyoshi; Konishi,Hideyuki; Manabe,Kei
    参考文献:Organic Letters 日期:2012 卷标:14(12) 页码:3100-3103]

    98-88-4 = 93-99-2
    反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Tetrabutylammonium Chloride Solvents: Dichloromethane,Water; 5 Min,0 °C
    标题:O-Acylation Of Substituted Phenols With Various Alkanoyl Chlorides Under Phase-Transfer Catalyst Conditions
    作者:Simion,Alina Marieta; Hashimoto,Iwao; Mitoma,Yoshiharu; Egashira,Naoyoshi; Simion,Cristian
    参考文献:Synthetic Communications 日期:2012 卷标:42(6) 页码:921-931]

    1523-15-5 + 100-67-4 = 93-99-2
    反应条件:1.1 Solvents: Dimethylformamide; 30 Min,20 °C
    标题:Enthalpy-Entropy Correlations In Reactions Of 2,4-Dinitrophenyl Benzoate With Phenols In The Presence Of Potassium Hydrogen Carbonate And With Potassium Phenoxides In Dimethylformamide
    作者:Khalfina,I. A.; Vlasov,V. M.
    参考文献:Russian Journal Of Organic Chemistry 日期:2011 卷标:47(6) 页码:845-854]

    98-88-4 + 139-02-6 = 93-99-2
    反应条件:1.1 Catalysts: Tributylamine,Chloromethylstyrene-Divinylbenzene-Styrene Copolymer Solvents: Water; 1 H,30 °C
    标题:Green Conversion Of Phenolic Compound To Benzoate Over Polymer-Supported Phase-Transfer Catalysts
    作者:Yang,Hung-Ming; Huang,Chin-Chen
    参考文献:Catalysis Letters 日期:2009 卷标:128(1-2) 页码:235-242]

    119-61-9 = 93-99-2
    反应条件:1.1 Reagents: 4-Aminobenzenecarboperoxoic Acid (Silica Supported) Catalysts: Hydrochloric Acid,Water Solvents: Chloroform; 8 H,Rt
    标题:Efficient Method For Oxidation Of Ketones To Esters With 4-Aminoperoxybenzoic Acid Supported On Silica Gel
    作者:Ghazanfari,Dadkhoda; Hashemi,Mohammed M.; Shahidi-Zandi,Mehdi
    参考文献:Synthetic Communications 日期:2008 卷标:38(12) 页码:2037-2042]

    98-88-4 = 93-99-2
    反应条件:1.1 Catalysts: Titania; 30 Min,25 °C
    标题:Tio2,A Simple And An Efficient Catalyst For Esterification Of Phenols Under Solvent-Free Condition
    作者:Pasha,Mohamed Afzal; Manjula,Krishnappa
    参考文献:Indian Journal Of Chemistry 日期:2008 卷标:(4) 页码:597-600]

    119-61-9 = 93-99-2
    反应条件:1.1 Reagents: M-Chloroperbenzoic Acid Catalysts: Trifluoromethanesulfonic Acid Solvents: Dichloromethane
    标题:Sc(Otf)3- And Tfoh-Catalyzed Baeyer-Villiger Oxidation Of Carbonyl Compounds With 3-Chloroperbenzoic Acid
    作者:Kotsuki,Hiyoshizo; Arimura,Koji; Araki,Tomohiro; Shinohara,Toshio
    参考文献:Synlett 日期:1999 卷标:(4) 页码:462-464]

    86379-22-8 = 93-99-2
    反应条件:1.1 Reagents: Hydrazine
    标题:Metal-Assisted Reactions. 13. Rapid,Selective Reductive Cleavage Of Phenolic Hydroxyl Groups By Catalytic Transfer Methods
    作者:Hussey,Brendan J.; Johnstone,Robert A. W.; Entwistle,Ian D.
    参考文献:Tetrahedron 日期:1982 卷标:38(24) 页码:3775-81]

    85909-02-0 = 93-99-2
    反应条件:1.1 Catalysts: Sodium Tert-Butoxide Solvents: Toluene; 24 H,150 °C; 150 °C -> Rt1.2 Solvents: Water; Rt
    标题:Hydrogen-Bond-Assisted Transition-Metal-Free Catalytic Transformation Of Amides To Esters
    作者:Huang,Changyu; Li,Jinpeng; Wang,Jiaquan; Zheng,Qingshu; Li,Zhenhua; Et Al
    参考文献:Science China: Chemistry 日期:2021 卷标:64(1) 页码:66-71]

    591-50-4 = 93-99-2
    反应条件:1.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Catalysts: Palladium (Phosphorus-Doped Porous Organic Polymer Supported) Solvents: Phenol; 8 H,1 Atm,80 °C
    标题:Carbonylative Suzuki Coupling And Alkoxycarbonylation Of Aryl Halides Using Palladium Supported On Phosphorus-Doped Porous Organic Polymer As An Active And Robust Catalyst
    作者:Wan,Yali; Song,Fangxiang; Ye,Tao; Li,Guangxing; Liu,Dingfu; Et Al
    参考文献:Applied Organometallic Chemistry 日期:2019 卷标:33(2)]

    591-50-4 = 93-99-2
    反应条件:1.1 Reagents: Potassium Hydroxide Catalysts: (Sp-4-3)-[3′,4′-Bis(4,5-Dihydro-4,4-Dimethyl-2-Oxazolyl-Kn3)[1,1′-Biphenyl]-4-Ol... (Solid-Supported) Solvents: Acetonitrile; Rt -> 120 °C; 6 H,100 Psi,120 °C
    标题:Catalytic Process For Synthesizing Ester Compounds And Amide Compounds
    参考文献:United States]

    93-97-0 = 93-99-2
    反应条件:1.1 Catalysts: 4-Pyridinamine,N,N-Dimethyl-,Hydrochloride (1:1) Solvents: Toluene; Rt -> 60 °C; 15 H,60 °C
    标题:Application Of Dmap Hydrochloride Serving As Recyclable Catalyst In Acylation Reaction
    参考文献:China]

    1864-94-4 = 93-99-2
    反应条件:1.1 Reagents: Triethylamine Catalysts: Triphenylphosphine,Di-μ-Chlorobis[2-[1-[(4-Methylphenyl)Imino-Kn]Ethyl]Ferrocenyl-Kc]Dipalladium Solvents: Dimethylformamide; 23 H,120 °C1.2 Reagents: Water
    标题:Palladacycle-Catalyzed Carbonylation Of Aryl Iodides Or Bromides With Aryl Formates
    作者:Chen,Guangwei; Leng,Yuting; Yang,Fan; Wang,Shiwei; Wu,Yangjie
    参考文献:Chinese Journal Of Chemistry 日期:2013 卷标:31(12) 页码:1488-1494]

    93-97-0 = 93-99-2
    反应条件:1.1 Catalysts: 4-Pyridinamine,N,N-Dimethyl-,Hydrochloride (1:1); 15 H,Rt
    标题:4-(N,N-Dimethylamino)Pyridine Hydrochloride As A Recyclable Catalyst For Acylation Of Inert Alcohols: Substrate Scope And Reaction Mechanism
    作者:Liu,Zhihui; Ma,Qiaoqiao; Liu,Yuxiu; Wang,Qingmin
    参考文献:Organic Letters 日期:2014 卷标:16(1) 页码:236-239]

    119-61-9 = 93-99-2
    反应条件:1.1 Reagents: Trifluoroacetic Anhydride,Sodium Percarbonate Solvents: Dichloromethane1.2 Reagents: Sodium Bicarbonate Solvents: Dichloromethane,Water
    标题:New Method Of Generating Trifluoroperoxyacetic Acid For The Baeyer-Villiger Oxidation
    作者:Kang,Ho-Jung; Jeon,Hee-Sun
    参考文献:Bulletin Of The Korean Chemical Society 日期:1996 卷标:17(1) 页码:5-6
📜苯甲酰溴 以94%的收率获得产物苯甲酸苯酯
参考文献:Process For Making Esters
标题:Process For Making Esters
摘要:羧酸酯是通过羧酸卤化物与碳酸酯在引发剂存在下的反应产生的.二羧酸二卤化物和双(烷基碳酸酯)酯的反应会产生聚酯.

海关参考信息

专利信息


专利号:US-3772389-A
优先权日:1971-06-24
标 题:Process for the synthesis of phenyl esters
发明人：LOWRANCE W
权利人:EASTMAN KODAK CO
摘要:A PROCESS FOR THE SYNTHESIS OF PHENYL ESTERS DIRECTLY FROM THE CORRESPONDING PHENOLS AND CARBOXYLIC ACIDS WHICH COMPRISES CONTACTING A PHENOLIC COMPOUND HAVING AT LEAST ONE HYDROGEN ATOM ADJACENT THE ACTIVE HYDROXYL GROUP WITH A CARBOXYLIC ACID COMPOUND CONTAINING AT LEAST ONE ACTIVE CARBOXYLIC GROUP IN THE PRESENCE OF A CATALYTIC AMOUNT OF A BORATE-SULFURIC ACID CATALYST COMPLEX. THE PROCESS IS CARRIED OUT IN A SINGLE STAGE REACTOR WHICH MAY BE OPERATED AT FROM 75*C. TO 285*C. UNDER ATMOSPHERIC, SUBATMOSPHERIC OR SUPERATMOSPHERIC PRESSURE. IF DESIRABLE, A SOLVENT CAN BE EMPLOYED.

专利号:US-9656927-B2
优先权日:2013-11-01
标题 :Process for the synthesis of carboxylic acid derivatives
发明人：KISHORE PRASAD PRAGATI; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES; COUNCIL SCIENT IND RES
摘要:The present invention discloses one-pot synthesis of various carboxylic acid derivatives using copper catalyst and sodium cyanide as the cyanide source for bringing in carbonylative coupling in a single step.

专利号:US-6512137-B1
优先权日:1999-01-26
标题 :Synthesis method of nitroxymethylphenyl esters of aspirin derivatives
发明人：DEL SOLDATO PIERO; GARUFI MICHELE
权利人:NICOX SA
摘要:The invention describes a method for the synthesis of nitroxymethylphenyl esters of aspirin derivatives.

专利号:US-12319712-B2
优先权日:2018-05-09
标 题:Methods of synthesizing a polynucleotide array using photoactivated agents
发明人：RAJASEKARAN JOHN J; JAYARAMAN VASANTH; VENUGOPAL ANIRUDH; BEI KANG; WANG TIANHAO; KRISHNA KARTHIK; KRISHNAMURTHY HARI KRISHNAN
权利人:VIBRANT HOLDINGS LLC
摘要:Described herein are methods for the synthesis of DNA polynucleotides and polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of DNA microarrays.

专利号:US-6066705-A
优先权日:1995-08-31
标 题 :Vapor phase synthesis of cis-1, 4-Polyisoprene
发明人：CALDERON NISSIM; CASTNER KENNETH FLOYD; COLVIN HOWARD ALLEN; MUSE JR JOEL
权利人:GOODYEAR TIRE & RUBBER
摘要:By utilizing the vapor phase polymerization techniques of the present invention, numerous distinct and highly beneficial advantages are realized. For instance, cis-1,4-polyisoprene rubber and high cis-1,4-polybutadiene rubber having a consistent and controllable molecular weight can be easily and practically prepared without utilizing a solvent. The subject invention more specifically discloses a method for vapor phase polymerizing isoprene into cis-1,4-polyisoprene in a process comprising the steps of: (1) charging into a reaction zone said isoprene and a preformed catalyst system which is made by reacting an organoaluminum compound with titanium tetrachloride, preferably in the presence of at least one ether; wherein the isoprene is maintained in the vapor phase in said reaction zone by a suitable combination of temperature and pressure; (2) allowing said isoprene to polymerize into cis-1,4-polyisoprene at a temperature within the range of about 35 DEG C. to about 70 DEG C.; and (3) withdrawing said cis-1,4-polyisoprene from said reaction zone. It has been determined that gel formation can be reduced by conducting the polymerization of isoprene monomer in the presence of a diarylamine, such as para-styrenated diphenylamine.

专利号:US-5859156-A
优先权日:1995-08-31
标 题 :Vapor phase synthesis of rubbery polymers
发明人：CALDERON NISSIM; MUSE JR JOEL; COLVIN HOWARD ALLEN; CASTNER KENNETH FLOYD
权利人:GOODYEAR TIRE & RUBBER
摘要:By utilizing the vapor phase polymerization techniques of the present invention, numerous distinct and highly beneficial advantages are realized. For instance, cis-1,4-polyisoprene rubber and high cis-1,4-polybutadiene rubber having a consistent and controllable molecular weight can be easily and practically prepared without utilizing a solvent. The subject invention more specifically discloses a method for vapor phase polymerizing isoprene into cis-1,4-polyisoprene in a process comprising the steps of: (1) charging into a reaction zone said isoprene and a preformed catalyst system which is made by reacting an organoaluminum compound with titanium tetrachloride, preferably in the presence of at least one ether; wherein the isoprene is maintained in the vapor phase in said reaction zone by a suitable combination of temperature and pressure; (2) allowing said isoprene to polymerize into cis-1,4-polyisoprene in said reaction zone at a temperature within the range of about 0 DEG C. to about 100 DEG C. in the presence of a diarylamine, wherein said reaction zone is a horizontal, stirred reactor of substantially circular cross section containing a centrally-located drive shaft extending longitudinally through said reactor to which are attached a plurality of adjacently located paddles, which paddles cause essentially no forward or backward movement of the cis-1,4-polyisoprene contained in said reactor; and (3) withdrawing said cis-1,4-polyisoprene from said reaction zone.

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主要参考文献

[参考文献]: Alvarez-Rivera G, Et Al. Pressurized Liquid Extraction-Gas Chromatography-Mass Spectrometry For Confirming The Photo-Induced Generation Of Dioxin-Like Derivatives And Other Cosmetic Preservative Photoproducts On Artificial Skin. J Chromatogr A. 2016 Apr 1;1440:37-44.
[参考文献]: Recasens M, Et Al. Chloride Transport Blockers Inhibit The Chloride-Dependent Glutamate Binding To Rat Brain Membranes. Neurosci Lett. 1987 Feb 24;74(2):211-6.
[参考文献]: A G Prat, Et Al. Cellular Atp Release By The Cystic Fibrosis Transmembrane Conductance Regulator. Am J Physiol. 1996 Feb;270(2 Pt 1):C538-45.
[参考文献]: D Chesnoy-Marchais, Et Al. Chloride Current Activated By Cyclic Amp And Parathyroid Hormone In Rat Osteoblasts. Pflugers Arch. 1989 Oct;415(1):104-14.
[参考文献]: Daun Jung, Et Al. Discrimination Of Skin Sensitizers From Non-Sensitizers By Interleukin-1α And Interleukin-6 Production On Cultured Human Keratinocytes. J Appl Toxicol. 2016 Sep;36(9):1129-36.

合成参考文献


摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 162.
摘要:Vrána, J.; Růžička, A., Science of Synthesis Knowledge Updates, (2021) 2, 33.
摘要:Mourad, A. K.; Czekelius, C., Science of Synthesis Knowledge Updates, (2011) 3, 81.
摘要:Li, G.; Szostak, M., Science of Synthesis Knowledge Updates, (2020) 2, 226.
摘要:Neumann, H.; Schranck, J., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 78.
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