CAS: 92146-82-2; Tert-Butyl 3-Aminobenzoate

该化合物是属于苯并酯类别的有机化合物,其特点是与酯功能组相连的双丁基组,与3-氨基苯甲酸酸酸碱有关,其典型特征是有机溶性中度,由于T-丁基苯基混合物的疏水性,水溶性有限,该化合物具有中等溶性,其特性在于该化合物在有机溶液中的溶解性有限;氨基化合物的存在为氢联结提供了潜力,影响氢在各种化学环境中的再活性和相互作用.T-Butyl 3-Minobenzoate可用于有机合成,特别是制药或作为其他化学化合物生产的中间体,在标准条件下,该物质是各种应用的合适选择方,尽管由于与含地雷化合物有关的潜在毒性,应当采取具体的处理预防措施.与所有化学品一样,在实验室或工业环境中处理该物质时,应当采取适当的安全措施.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

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CAS号58656-99-8 3-硝基苯甲酸叔丁酯 | CAS号1257310-83-0 3-(2-trimethyls... | CAS号69038-74-0 3-溴苯甲酸叔丁酯 | CAS号1045771-49-0 3-[2-(trimethyl... | CAS号121-92-6 间硝基苯甲酸 | CAS号41221-47-0 3-羧甲氧基苯基异氰酸酯 | CAS号486415-53-6 3-(叔丁基羰基)苯基异硫氰酸 | CAS号602307-41-5 tert-butyl 3-se...

合成工艺路线路线简述

  • 1257310-83-0 = 92146-82-2
    反应条件:1.1 Reagents: Cesium Fluoride Solvents: Dimethylformamide; 8 H,45 °C
    标题:Carbamic Acid 2-Trimethylsilylethyl Ester As A New Ammonia Equivalent For Palladium-Catalyzed Amination Of Aryl Halides
    作者:Mullick,Dibakar; Anjanappa,Prakash; Selvakumar,Kumaravel; Ruckmani,Kandasamy; Sivakumar,Manickam
    参考文献:Tetrahedron Letters 日期:2010 卷标:51(46) 页码:5984-5987]

    1045771-49-0 = 92146-82-2
    反应条件:1.1 Reagents: Cesium Fluoride Solvents: Dimethylformamide; 36 H,130 °C
    标题:2-(Trimethylsilyl)Ethanesulfonyl Amide As A New Ammonia Equivalent For Palladium-Catalyzed Amination Of Aryl Halides
    作者:Anjanappa,Prakash; Mullick,Dibakar; Selvakumar,Kumaravel; Sivakumar,Manickam
    参考文献:Tetrahedron Letters 日期:2008 卷标:49(31) 页码:4585-4587]

    58656-99-8 = 92146-82-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; Overnight,1 Atm,Rt
    标题:Selective And Reversible Modification Of Kinase Cysteines With Chlorofluoroacetamides
    作者:Shindo,Naoya; Fuchida,Hirokazu; Sato,Mami; Watari,Kosuke; Shibata,Tomohiro; Et Al
    参考文献:Nature Chemical Biology 日期:2019 卷标:15(3) 页码:250-258]

    58656-99-8 = 92146-82-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol; 4 H,60 Psi,23 °C
    标题:Selective Urokinase-Type Plasminogen Activator Inhibitors. 1-(7-Sulfonamidoisoquinolinyl)Guanidines
    作者:Fish,Paul V.; Barber,Christopher G.; Brown,David G.; Butt,Richard; Collis,Michael G.; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2007 卷标:50(10) 页码:2341-2351]

    = 92146-82-2 [标题:Reaction Conditions
    标题:Preparation Of 1,5-Benzodiazepine Derivatives As Cck-A Receptor Agonists
    参考文献:World Intellectual Property Organization]

    = 92146-82-2 [标题:Reaction Conditions
    标题:Preparation Of Pyridone- And Pyrimidoneacetamides And Their Intermediates And Their Pharmaceutical Use As Chymase Inhibitors
    参考文献:Japan]

    58656-99-8 = 92146-82-2
    反应条件:1.1 Reagents: Iron,Ammonium Chloride Solvents: Ethanol,Water; 2 H,95 °C
    标题:Innovative Multipodal Ligands Derived From Troeger'S Bases For The Sensitization Of Lanthanide(Iii) Luminescence
    作者:Trupp,Leandro; Bruttomesso,Andrea C.; Varde,Mariana; Eliseeva,Svetlana V.; Ramirez,Javier A.; Et Al
    参考文献:Chemistry - A European Journal 日期:2020 卷标:26(70) 页码:16900-16909]

    58656-99-8 = 92146-82-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; Rt
    标题:Rational Design Of Substituted Diarylureas: A Scaffold For Binding To G-Quadruplex Motifs
    作者:Drewe,William C.; Nanjunda,Rupesh; Gunaratnam,Mekala; Beltran,Monica; Parkinson,Gary N.; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2008 卷标:51(24) 页码:7751-7767]

    58656-99-8 = 92146-82-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 3.5 H
    标题:Ureylene Derivatives As Dna Oligonucleotide Ligands And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Diseases
    参考文献:World Intellectual Property Organization]

    58656-99-8 = 92146-82-2
    反应条件:1.1 Reagents: Ammonium Formate Catalysts: Palladium Solvents: Ethanol,Water; 2 H,50 °C
    标题:Preparation Of Hydroxyethylamine Derivatives For The Treatment Of Alzheimer'S Disease
    参考文献:World Intellectual Property Organization]

    24424-99-5 + 121-92-6 = 92146-82-2
    反应条件:1.1 Reagents: 4-(Dimethylamino)Pyridine Solvents: Tert-Butanol1.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol
    标题:New Selenyl Linker For Solid-Phase Synthesis Of Dehydropeptides
    作者:Nakamura,Kazuhiko; Ohnishi,Yuki; Horikawa,Eiji; Konakahara,Takeo; Kodaka,Masato; Et Al
    参考文献:Tetrahedron Letters 日期:2003 卷标:44(29) 页码:5445-5448]

    16537-17-0 = 92146-82-2
    反应条件:1.1 Reagents: Ammonia,Tripotassium Phosphate Catalysts: Copper,2633071-98-2 Solvents: Dimethyl Sulfoxide,Water; 48 H,80 °C
    标题:Porous Polymeric Ligand Promoted Copper-Catalyzed C-N Coupling Of (Hetero)Aryl Chlorides Under Visible-Light Irradiation
    作者:Wang,Erfei; Chen,Kaixuan; Chen,Yinan; Zhang,Jiawei; Lin,Xinrong; Et Al
    参考文献:Science China: Chemistry 日期:2021 卷标:64(1) 页码:17-21]

    69038-74-0 = 92146-82-2
    反应条件:1.1 Reagents: Sodium Tert-Butoxide,Rink Amide Am Catalysts: Tris(Dibenzylideneacetone)Dipalladium,Binap Solvents: Tert-Butanol,1,4-Dioxane; 18 - 20 H,80 °C1.2 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; 45 Min,Rt
    标题:Palladium-Catalyzed Amination Of Aryl Halides On Solid Support
    作者:Weigand,Klaus; Pelka,Sylvie
    参考文献:Organic Letters 日期:2002 卷标:4(26) 页码:4689-4692]

    58656-99-8 = 92146-82-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol; 4 H,60 Psi,23 °C
    标题:Preparation Of Guanidinoisoquinolines As Urokinase Inhibitors
    参考文献:United States]

    58656-99-8 = 92146-82-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol; 4 H,60 Psi,23 °C
    标题:Preparation Of Isoquinolinylguanidines As Urokinase Inhibitors
    参考文献:World Intellectual Property Organization]

    = 92146-82-2 [标题:Reaction Conditions
    标题:Preparation Of Novel Selenyl Linkers And Their Use As Intermediates For Double Bond-Containing Compounds
    参考文献:Japan]

    = 92146-82-2 [标题:Reaction Conditions
    标题:Preparation Of 1,4-Benzodiazepin-2-One-1-Acetamides As Cholecystokinin-A Receptor Agonists
    参考文献:World Intellectual Property Organization]

    = 92146-82-2 [标题:Reaction Conditions
    标题:Preparation Of Cck Or Gastrin Modulating 5-Heterocyclyl-1,5-Benzodiazepinediones
    参考文献:World Intellectual Property Organization]

    = 92146-82-2 [标题:Reaction Conditions
    标题:Preparation Of 1,5-Benzodiazepine Derivatives As Cholecystokinin And/or Gastrin Antagonists
    参考文献:World Intellectual Property Organization
📜间硝基苯甲酸置于palladium On Activated Charcoal 4-二甲氨基吡啶,二碳酸二叔丁酯,氢气体系中,用 乙醇 作为反应溶剂,化学反应生成 3-氨基苯甲酸叔丁酯
参考文献:用于固相合成脱氢肽的新型硒基连接体
标题:用于固相合成脱氢肽的新型硒基连接体
摘要:开发了一种具有硒氰酸酯和被掩蔽的羧酸的新型接头,用于固相合成脱氢肽.该接头用于证明rgd-缀合的脱氢肽的模型化合物的合成.
DOI:10.1016/s0040-4039(03)01309-1

海关参考信息

专利信息


专利号:US-2005026965-A1
优先权日:2000-12-29
标 题 :Pharmaceutical uses and synthesis of nicotinanilide-N-oxides

专利号:US-2003004189-A1
优先权日:2000-12-29
标 题 :Pharmaceutical uses and synthesis of nicotinanilide-N-oxides

专利号:US-2010063105-A1
优先权日:2000-12-29
标题 :Pharmaceutical uses and synthesis of nicotinanilide-n-oxides

专利号:US-7141590-B2
优先权日:2000-12-29
标题 :Pharmaceutical uses and synthesis of nicotinanilide-N-oxides
发明人：CUTSHALL NEIL S; YAGER KRAIG M
权利人:UCB SA
摘要:Disclosed are nicotinanilide-N-oxide compounds, methods for their production, pharmaceutical compositions which include these compounds, and methods for their use in various therapies.

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参考文献:10.1007/s00706-018-2212-0
摘要:Linder T, Schnürch M, Mihovilovic MD. One-pot synthesis of triazines as potential agents affecting cell differentiation. Monatshefte für Chemie - Chemical Monthly. 2018 May 15;149(7):1257–84. doi: 10.1007/s00706-018-2212-0.
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