CAS: 920014-72-8; (4R,7S,10S,13R,16S,19R,22R)-16-((1H-Imidazol-4-yl)Methyl)-7-((1H-Indol-3-yl)Methyl)-22-((S)-2-Acetamido-5-Guanidinopentanamido)-13-Benzyl-10-(3-Guanidinopropyl)-19-Methyl-6,9,12,15,18,21-Hexaoxo-1,2-Dithia-5,8,11,14,17,20-Hexaazacyclotricosane-4-Carboxamide

📜D-丙氨酸,S-三苯甲基-L-半胱氨酸,Fmoc-D-苯丙氨酸,Alkaline Earth Salt Of/the/ Methylsulfuric Acid,Alkaline Earth Salt Of/the/ Methylsulfuric Acid,Alkaline Earth Salt Of/the/ Methylsulfuric Acid,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于o-(1H-Benzotriazol-1-yl)-N,N,N',N'-Tetramethyluronium Hexafluorophosphate,N,N-二异丙基乙胺,哌啶体系中,用 N,N-二甲基甲酰胺,二氯甲烷 作为反应溶剂,以67 %的收率获得产物司美诺肽
参考文献:固相肽大环化中二硫键的快速高效组装
标题:固相肽大环化中二硫键的快速高效组装
摘要:在这里,我们使用过硫酸盐作为碘介导的氧化环化中的关键添加剂,在 15 分钟内报告了一种高效的二硫化物驱动的肽大环化.该方法消除了经典碘介导的肽环化的副产物.它操作简单方便,可一步环化包含流行半胱氨酸结构单元的小肽到较长肽.
DOI:10.1021/acs.Orglett.3C00078

专利信息

专利号:WO-2025045059-A1
优先权日:2023-09-01
标题 :Use of anti-igf-1r antibody or antigen binding portion thereof in weight loss
发明人：LIANG XIAO; GUO SHUHUA; MA LIN; PANG LIANG
权利人:SUZHOU PRO HEAL PHARMACEUTICALS TECH CO LTD
摘要:Provided is a use of an anti-IGF-1R antibody or an antigen binding portion thereof in weight loss. The anti-IGF-1R antibody or the antigen binding portion thereof carries out weight loss by means of at least one of the following mechanisms: (1) inhibiting or blocking the binding between IGF-1R and IGF-1; (2) reducing, weakening or neutralizing the activity of IGF-1R; (3) inhibiting cell proliferation; (4) inhibiting fat synthesis and/or accumulation of cells; and (5) inhibiting collagen synthesis of cells. The anti-IGF-1R antibody or the antigen binding portion thereof can significantly inhibit the generation and accumulation of fat, effectively inhibit the formation of collagen, and has a significant effect in treatment of obesity and weight loss.

专利号:US-2024199685-A1
优先权日:2022-12-15
标 题 :Preparation method of setmelanotide by cyclization of disulfide bond in solid phase
发明人：HSU YAO-LUNG; LEE CHUN-I; LIN CHUN-LING; HUANG YA-LING; LEE JIA-CHUN
权利人:CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO LTD
摘要:The present disclosure provides a preparation method of setmelanotide by cyclization of a disulfide bond in a solid phase. By using different solvents or mixed solvents to carry out a cyclization reaction in a solid phase, the reaction concentration can be greatly increased in comparison with a cyclization reaction in a liquid phase, and the production of impurities can also be reduced, so that the effects of reducing the use of the solvents and increasing the production capacity are achieved.

专利号:CN-119390613-A
优先权日:2024-10-22
标 题:Synthesis method of arginine derivative containing Cbz/Boc protecting group