6-Methyl-1,2-Dihydroquinoline置于sodium Hydrogen Sulfate,Cro2(1-)*na(1+),Silica Gel体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 6-甲基喹啉 参考文献:Oxidation Of 1,2-Dihydroquinolines Under Mild And Heterogeneous Conditions 标题:Oxidation Of 1,2-Dihydroquinolines Under Mild And Heterogeneous Conditions 摘要:A Combination Of Nahso4.H2O And Na2Cr2O7.2H(2)O In The Presence Of Wet Sio2 Were Used As An Effective Oxidizing Agent For The Oxidation Of 1,2-Dihydroquinolines To Their Corresponding Quinoline Derivatives In Dichloromethane At Room Temperature With Excellent Yields. DOI:10.1081/scc-100105895
专利号:EP-0255715-B1 优先权日:1986-08-07 标题 :Process for the synthesis of heterocycles from palladocyclic complexes 摘要:Heterocylic rings are synthesised from palladocyclic complexes by reaction with alkynes, characterised in that the palladocyclic complexes are employed in the form of iodo or cationic complexes. The process applies in particular to the synthesis of nitrogenous heterocyclic rings.
专利号:US-9982005-B2 优先权日:2013-04-04 标 题 :Macrolides and methods of their preparation and use 发明人:MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG 权利人:HARVARD COLLEGE 摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.
专利号:US-7935827-B2 优先权日:2003-12-31 标题 :Optically active, heteroaromatic β-hydroxy esters and processes for their preparation from β-keto esters and processes for the preparation of these β-keto esters 发明人:PLATZEK JOHANNES; ZORN LUDWIG; BUCHMANN BERND; SKUBALLA WERNER; PETROV ORLIN 权利人:BAYER SCHERING PHARMA AG 摘要:The present invention relates to new optically active heteroaromatic β-hydroxy esters useful in the synthesis of epothilone derivatives, to certain compounds used to produce these intermediates, as well as to processes for their production.
专利号:US-8378099-B2 优先权日:1994-10-28 标 题:Boronic ester and acid compounds, synthesis and uses 发明人:ADAMS JULIAN; MA YU-TING; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS 权利人:MILLENNIUM PHARMACUETICALS INC; ADAMS JULIAN; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS 摘要:Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
专利号:US-2010216863-A1 优先权日:2004-01-30 标 题 :Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment 发明人:HELGADOTTIR ANNA; HAKONARSON HAKON; GULCHER JEFFREY R; GURNEY MARK E 权利人:DECODE GENETICS EHF 摘要:Polymorphisms in the FLAP and LTA4H gene are shown by genetic association analysis to be susceptibility markers for myocardial infarction (MI) and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described. The invention also provides methods of prophylaxis therapy for MI in human subjects having a race including black African ancestry by administering to the subject a composition comprising a therapeutically effective amount of MI therapeutic agent that inhibits leukotriene synthesis in vivo. The invention also provides for compositions comprising a leukotriene synthesis inhibitor and a statin and methods of using these compositions to reduce C-reactive protein in a human subject at risk of MI, ACS, stroke and/or PAOD.
专利号:US-2006019269-A1 优先权日:2002-10-17 标题:Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment 发明人:HELGADOTTIR ANNA; HAKONARSON HAKON; GULCHER JEFFREY R; GURNEY MARK E 权利人:DECODE GENETICS INC 摘要:Linkage of myocardial infarction (MI) and a locus on chromosome 13q12 is disclosed. In particular, the FLAP gene within this locus is shown by genetic association analysis to be a susceptibility gene for MI and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described. The invention also provides for compositions comprising a leukotriene synthesis inhibitor and a stating and methods of using these compositions to reduce C-reactive protein in a human subject at risk of MI, ACS, stroke and/or PAOD.
参考文献:10.1107/s1600536811007021 摘要:Hyun MY, Kim P, Kim C, Kim Y. catena-Poly[[tetraaqua[trans-1,2-bis(4-pyridyl)ethene-κ2N:N′]nickel(II)] dinitrate]. Acta Crystallogr E Struct Rep Online. 2011 Mar 02;67(4):m390. doi: 10.1107/s1600536811007021.