CAS: 91-62-3; 6-Methylquinoline

该化合物是属于quinoline家族的有机化合物,其特点是由苯环和环组成的双环结构引信,其分子式为C10H9N,表示含有10个碳原子,9个氢原子和1个氮原子.该化合物一般是黄色液体或固体,视温度和纯度而定.该化合物有独特的芳香味,溶于乙醇和乙醇等有机溶剂,但水中溶液较少. 6-甲基基尼线因其在各种化学反应中的作用而著称,包括作为合成制药和农用化学品的一个构件.它具有荧光特性,有助于某些分析应用.此外,已经对其潜在的生物活动进行了研究,包括抗微生物和抗癌特性.然而,与许多有机化合物一样,在处理时,应注意潜在的毒性和环境影响.在实验室环境中与该物质合作时,应注意适当的安全措施.

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CAS号91-61-2 喹啉,1,2,3,4-四氢-6-甲基喹啉 | CAS号14002-34-7 三(3-羟基丙基)胺 | CAS号99-99-0 对硝基甲苯 | CAS号1092513-18-2 6-quinolyl mesylate | CAS号13061-96-6 甲基硼酸 | CAS号97531-28-7 6-methyl-1,2-di... | CAS号156-87-6 3-氨基丙醇 | CAS号3179-63-3 3-二甲氨基-1-丙醇 | CAS号106-49-0 对甲苯胺 | CAS号50358-35-5 5-氨基-6-甲基喹啉 | CAS号608-05-9 5-甲基靛红 | CAS号91-61-2 喹啉,1,2,3,4-四氢-6-甲基喹啉 | CAS号52601-65-7 6-methyl-5,6,7,... | CAS号1780-19-4 1.2.3.4-四氢-2-甲基喹啉 | CAS号29969-49-1 1,6-二甲基-2(1H)-喹啉酮 | CAS号849807-09-6 2-氯喹啉-6-羧酸甲酯 | CAS号89-00-9 吡啶-2,3-二羧酸 | CAS号101279-39-4 6-溴甲基喹啉 | CAS号4113-04-6 喹啉-6-甲醛

合成工艺路线路线简述

    6-Methyl-1,2-Dihydroquinoline置于sodium Hydrogen Sulfate,Cro2(1-)*na(1+),Silica Gel体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 6-甲基喹啉
    参考文献:Oxidation Of 1,2-Dihydroquinolines Under Mild And Heterogeneous Conditions
    标题:Oxidation Of 1,2-Dihydroquinolines Under Mild And Heterogeneous Conditions
    摘要:A Combination Of Nahso4.H2O And Na2Cr2O7.2H(2)O In The Presence Of Wet Sio2 Were Used As An Effective Oxidizing Agent For The Oxidation Of 1,2-Dihydroquinolines To Their Corresponding Quinoline Derivatives In Dichloromethane At Room Temperature With Excellent Yields.
    DOI:10.1081/scc-100105895

    海关参考信息

    专利信息


    专利号:EP-0255715-B1
    优先权日:1986-08-07
    标题 :Process for the synthesis of heterocycles from palladocyclic complexes
    摘要:Heterocylic rings are synthesised from palladocyclic complexes by reaction with alkynes, characterised in that the palladocyclic complexes are employed in the form of iodo or cationic complexes. The process applies in particular to the synthesis of nitrogenous heterocyclic rings.

    专利号:US-9982005-B2
    优先权日:2013-04-04
    标 题 :Macrolides and methods of their preparation and use
    发明人:MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
    权利人:HARVARD COLLEGE
    摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

    专利号:US-7935827-B2
    优先权日:2003-12-31
    标题 :Optically active, heteroaromatic β-hydroxy esters and processes for their preparation from β-keto esters and processes for the preparation of these β-keto esters
    发明人:PLATZEK JOHANNES; ZORN LUDWIG; BUCHMANN BERND; SKUBALLA WERNER; PETROV ORLIN
    权利人:BAYER SCHERING PHARMA AG
    摘要:The present invention relates to new optically active heteroaromatic β-hydroxy esters useful in the synthesis of epothilone derivatives, to certain compounds used to produce these intermediates, as well as to processes for their production.

    专利号:US-8378099-B2
    优先权日:1994-10-28
    标 题:Boronic ester and acid compounds, synthesis and uses
    发明人:ADAMS JULIAN; MA YU-TING; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS
    权利人:MILLENNIUM PHARMACUETICALS INC; ADAMS JULIAN; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS
    摘要:Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.

    专利号:US-2010216863-A1
    优先权日:2004-01-30
    标 题 :Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
    发明人:HELGADOTTIR ANNA; HAKONARSON HAKON; GULCHER JEFFREY R; GURNEY MARK E
    权利人:DECODE GENETICS EHF
    摘要:Polymorphisms in the FLAP and LTA4H gene are shown by genetic association analysis to be susceptibility markers for myocardial infarction (MI) and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described. The invention also provides methods of prophylaxis therapy for MI in human subjects having a race including black African ancestry by administering to the subject a composition comprising a therapeutically effective amount of MI therapeutic agent that inhibits leukotriene synthesis in vivo. The invention also provides for compositions comprising a leukotriene synthesis inhibitor and a statin and methods of using these compositions to reduce C-reactive protein in a human subject at risk of MI, ACS, stroke and/or PAOD.

    专利号:US-2006019269-A1
    优先权日:2002-10-17
    标题:Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
    发明人:HELGADOTTIR ANNA; HAKONARSON HAKON; GULCHER JEFFREY R; GURNEY MARK E
    权利人:DECODE GENETICS INC
    摘要:Linkage of myocardial infarction (MI) and a locus on chromosome 13q12 is disclosed. In particular, the FLAP gene within this locus is shown by genetic association analysis to be a susceptibility gene for MI and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described. The invention also provides for compositions comprising a leukotriene synthesis inhibitor and a stating and methods of using these compositions to reduce C-reactive protein in a human subject at risk of MI, ACS, stroke and/or PAOD.
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    合成参考文献


    参考文献:10.1107/s1600536811007021
    摘要:Hyun MY, Kim P, Kim C, Kim Y. catena-Poly[[tetraaqua[trans-1,2-bis(4-pyridyl)ethene-κ2N:N′]nickel(II)] dinitrate]. Acta Crystallogr E Struct Rep Online. 2011 Mar 02;67(4):m390. doi: 10.1107/s1600536811007021.
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