CAS: 88082-66-0; (1R,2R)-2-Amino-1,2-Diphenylethanol

该化合物是一个有机化合物,其特点是氨基酒精结构;该化合物的特征是碳链中附带一个联苯组,该碳链中既包括氨基化合物(-NH2),也包括氢氧化物(-OH),这些碳链组是关键功能组,有助于其反应性和溶性特性.(R,R)的注解表明,在手工业中心周围的原子有具体的空间安排,可能影响该化合物的生物活动和相互作用.一般来说,由于氨基和氢氧化合物组的存在,这种氨基酒精可以参与氢的结合,提高它们在极溶溶剂中的溶性.这种化合物还可能在制药中表现出潜在的应用,特别是在生物活性分子合成或有机合成的中间体方面.但是,具体的应用和生物活动将取决于进一步的经验研究和背景.

英文名称(1R,2R)-2-Amino-1,2-Diphenylethanol
中文名称(1R,2R)-2-氨基-1,2-二苯基乙醇
IUPAC名称(1R,2R)-2-amino-1,2-diphenylethanol
其它别名(R,R)-(+)-2-氨基-1,2-二苯基乙醇; (R,R)-(+)-2-Amino-1,2-Diphenylethanol
CAS编号88082-66-0
MFCD编号:MFCD03093885
EINECS号:635-830-8
分子式:C14H15NO分子量:213.28
产品CID: 1889836
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: GEJJWYZZKKKSEV-ZIAGYGMSSA-N
InChI=1/C14H15NO/c15-13(11-7-3-1-4-8-11)14(16)12-9-5-2-6-10-12/h1-10,13-14,16H,15H2/t13-,14-/s3
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数3.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
警示词Warning(警告)
危险描述H302 |吞咽有害.
防范说明P264-P280-P302+P352-P362
UN编号NONH for all modes of transport
危险品标志Xi,Xn
安全声明26-36
危险类别码36/37/38-22
WGK Germany3.0

欧盟法规

C&L通报

上下游产品

ethanol L-Tartaric acid threo-1,2-diphenyl-2-aminoethan-1-ol benzil dioxime dichloro-acetic acid-(α'-hydroxy-bibenzyl-α-ylamide) (1R,2R)-2-amino-1,2-diphenylethane-1-ol 1,2-diphenyl-1,2-ethanediol (1S,2S)-2-amino-1,2-diphenylethanol

合成工艺路线路线简述

131350-15-7 = 88082-66-0
反应条件:1.1 Reagents: Thionyl Chloride; 10 Min,0 °C; 30 Min,23 °C1.2 Reagents: Water; Cooled; 2 H,125 °C; 125 °C -> 23 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; 30 Min,23 °C
标题:Pseudoephenamine: A Practical Chiral Auxiliary For Asymmetric Synthesis
作者:Morales,Marvin R.; Mellem,Kevin T.; Myers,Andrew G.
参考文献:Angewandte Chemie 日期:2012 卷标:51(19) 页码:4568-4571]

23364-44-5 = 88082-66-0 [标题:Reaction Conditions
标题:Asymmetric Cyclopropanation Catalyzed By A Series Of Copper-(Schiff-Base) Complexes With Two Chiral Centers
作者:Jiang,Changsheng; Zhang,Ming; Tan,Qitao; Qian,Dai; You,Tianpa
参考文献:Enantiomer 日期:2002 卷标:7(6) 页码:287-293]

525579-05-9 = 88082-66-0
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 12 H,Rt
标题:Single Route To Chiral Syn- And Anti-2-Amino-1,2-Diphenylethanols Via A New Stereodivergent Opening Of Trans-1,2-Diphenyloxirane
作者:Lupattelli,Paolo; Bonini,Carlo; Caruso,Leonilde; Gambacorta,Augusto
参考文献:Journal Of Organic Chemistry 日期:2003 卷标:68(8) 页码:3360-3362]

131350-15-7 = 88082-66-0
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Acetonitrile; 0 °C; < 15 °C; 30 Min,0 °C; < 15 °C; 2 H,0 °C1.2 Reagents: Water; 0 °C -> 5 °C; < 30 °C; 12 H,90 °C; 90 °C -> 5 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; 2 H,Ph 11,15 °C
标题:Large-Scale Preparation Of Key Building Blocks For The Manufacture Of Fully Synthetic Macrolide Antibiotics
作者:Hogan,Philip C.; Chen,Chi-Li; Mulvihill,Kristen M.; Lawrence,Jonathan F.; Moorhead,Eric; Et Al
参考文献:Journal Of Antibiotics 日期:2018 卷标:71(2) 页码:318-325]

681440-07-3 = 88082-66-0
反应条件:1.1 Reagents: Chloro(1-Methylethyl)Magnesium Catalysts: Bis(Acetylacetonato)Nickel,1,3-Bis(Diphenylphosphino)Propane Solvents: Diethyl Ether; 12 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water
标题:Ortho-Anisylsulfonyl As A Protecting Group For Secondary Amines: Mild Ni0-Catalyzed Hydrodesulfonylation
作者:Milburn,Robert R.; Snieckus,Victor
参考文献:Angewandte Chemie 日期:2004 卷标:43(7) 页码:892-894]

1689-71-0 = 88082-66-0
反应条件:1.1 Reagents: Benzophenone Imine Catalysts: [2,2′-Bipyridine]-6,6′-Dimethanol,α6,α6′-Bis(1,1-Dimethylethyl)-,(α6R,α6′r)-,Scandium Triflate Solvents: Dichloromethane; 3 D,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 4 H,60 °C
标题:Catalytic,Enantioselective Synthesis Of Boc-Protected 1,2-Amino Alcohols Through Aminolysis Of Meso-Epoxides With Benzophenone Imine
作者:Mai,Enzo; Schneider,Christoph
参考文献:Arkivoc (Gainesville 日期:2008 卷标:(16) 页码:216-222]

100-52-7 = 88082-66-0
反应条件:1.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene,Sodium Sulfate Catalysts: 2837182-24-6 Solvents: Dichloromethane,Toluene; 30 H,-5 °C1.2 Reagents: Hydroxylamine Solvents: Tetrahydrofuran,Water; 1 H,Rt
标题:Catalytic Asymmetric α C(Sp3)-H Addition Of Benzylamines To Aldehydes
作者:Hou,Chengkang; Peng,Bingfei; Ye,Shen; Yin,Zeyang; Cao,Jing; Et Al
参考文献:Nature Catalysis 日期:2022 卷标:5(11) 页码:1061-1068]

23364-44-5 = 88082-66-0
反应条件:1.1 Reagents: Formamide Solvents: Formamide; 15 Min,150 °C; Cooled1.2 Reagents: Thionyl Chloride; 10 Min,5 °C; 5 °C -> Rt1.3 Reagents: Water; 2 H,Reflux1.4 Reagents: Carbon; Cooled1.5 Reagents: Sodium Hydroxide Solvents: Water; Basified,Rt
标题:Stereoselective Synthesis Of γ-Lactams From Imines And Cyanosuccinic Anhydrides
作者:Tan,Darlene Q.; Younai,Ashkaan; Pattawong,Ommidala; Fettinger,James C.; Cheong,Paul Ha-Yeon; Et Al
参考文献:Organic Letters 日期:2013 卷标:15(19) 页码:5126-5129]

100-52-7 + 56-40-6 = 88082-66-0
反应条件:1.1 Solvents: Ethanol,Water
标题:Erlenmeyer Reaction. Ii. Mechanism Of Dl-Threo-N-Benzal-Diphenylhydroxyethylamine Formation
作者:Harada,Kaoru
参考文献:Bulletin Of The Chemical Society Of Japan 日期:1969 卷标:42(7) 页码:2059-61

📜(4R,5R)-2,2-Dimethyl-4,5-Diphenyl-Oxazolidine置于盐酸体系中,化学反应生成 (1R,2R)-2-氨基-1,2-二苯乙醇
参考文献:邻氨基苯甲酰基磺酰基作为仲胺的保护基:温和的ni催化加氢脱磺酰基反应.
标题:邻氨基苯甲酰基磺酰基作为仲胺的保护基:温和的ni催化加氢脱磺酰基反应.
摘要:
DOI:10.1002/anie.200352634