CAS: 82650-83-7; (E)-2-(5-(4-Methylpiperazin-1-yl)-9H-Dithieno[3,4-B:3',4'-E]Azepin-9-Ylidene)Acetonitrile
- 英文名称(E)-2-(5-(4-Methylpiperazin-1-yl)-9H-Dithieno[3,4-B:3',4'-E]Azepin-9-Ylidene)Acetonitrile
- 中文名称替尼拉平
- IUPAC名称(E)-2-(5-(4-methylpiperazin-1-yl)-9H-dithieno[3,4-b:3',4'-e]azepin-9-ylidene)acetonitrile
- 其它别名Tenilapine; [(9E)-5-(4-Methylpiperazin-1-yl)-9H-Dithieno[3,4-B:3',4'-E]Azepin-9-Ylidene]Acetonitrile; Tenilapine Usp/ep/bp
- CAS编号82650-83-7
- MFCD编号:MFCD00868494
- FDA UNII编号:D0U312O2BE
- 分子式:C17H16N4S2分子量:340.48
- 产品CID: 1816730
- 产品分类原料药 → 抗肿瘤药 → 替尼类抗肿瘤药
物理性质
MSDS等安全信息
上下游产品
1-methyl-piperazine合成工艺路线路线简述
📜(2E)-2-(9-Chloro-5,12-Dithia-8-Azatricyclo[8.3.0.03,7]Trideca-1(13),3,6,8,10-Pentaen-2-Ylidene)Acetonitrile 反应生成 替尼拉平
参考文献:Steiner,G.;Teschendorf,H.-J.;Kreiskott,H.;Hofmann,H. P.
标题:Steiner,G.;Teschendorf,H.-J.;Kreiskott,H.;Hofmann,H. P.
海关参考信息
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2901220000-丙烯
2921211000-乙二胺
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专利信息
专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.
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主要参考文献
1: Pharmacological Analysis of the Novel, Rapid, and Potent Inactivation of the Human 5-Hydroxytryptamine7 Receptor by Risperidone, 9-OH-Risperidone, and Other Inactivating Antagonists Jessica A. Knight, Carol Smith, Nicole Toohey, Michael T. Klein, Milt Teitler Mol Pharmacol. 2009 Feb; 75(2): 374–380. Published online 2008 Nov 7. doi: 10.1124/mol.108.052084 2018 Jun; 2018(6): CD005594. Published online 2018 Jun 18. doi: 10.1002/14651858.CD005594.pub3 Klein, Jessica Knight, Carol Smith, Milt Teitler Mol Pharmacol. 2009 Sep; 76(3): 552–559. Published online 2009 Jun 9. doi: 10.1124/mol.109.056283 2010 Jun; 16(3): 179–194. Published online 2010 May 6. doi: 10.1111/j.1755-5949.2010.00135.x PMCID: PMC6493878
合成参考文献
参考文献:10.1007/978-1-60761-941-3_11
摘要:Di Giovanni G, Esposito E, Di Matteo V. The 5-HT2C Receptor Subtype Controls Central Dopaminergic Systems: Evidence from Electrophysiological and Neurochemical Studies. 2010 Nov 10. In: 5-HT2C Receptors in the Pathophysiology of CNS Disease. : Humana Press; 2010 Nov 10.
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