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Boc-L-脯氨酸甲酯置于二异丁基氢化铝体系中,用 正己烷,二氯甲烷 作为反应溶剂,化学反应 3.0H,反应生成 (S)-N-Boc-吡咯烷-2-甲醛 N-(叔丁氧羰基)-L-脯氨醛
参考文献:立体控制在不对称小号ë γ取代的α,β不饱和醛的"反应
标题:立体控制在不对称小号ë γ取代的α,β不饱和醛的"反应
摘要:研发了(e)-和(z)-γ-取代的α,β-不饱和醛的不对称s E '反应,用于立体控制非外消旋醇的制备.烯丙基锡烷的温和交换反应可提供手性1,3-双(甲苯磺酰基)-4,5-二苯基-1,3-二氮杂-2-硼烷核苷.这些试剂与γ-取代的α,β-不饱和醛具有反应性,其特征在于立体控制的元素匹配和错配.计算分析(使用密度泛函理论)提供了宝贵的见识,可指导反应的发展.
DOI:10.1021/ol403351X

专利信息

专利号:US-5869725-A
优先权日:1994-05-17
标 题:Derivatives of aminosulfonic acids, utilization of the same in the synthesis of pseudopeptides and process for their preparation
发明人：GENNARI CESARE; POTENZA DONATELLA; SALOM BARBARA
权利人:PHARMACIA & UPJOHN SPA
摘要:Derivatives of gamma-amino-alpha,beta-unsaturated sulfonic acids, a process for the preparation of the same and their utilization in the synthesis of pseudopeptides characterized by the presence of at least a sulfonamide type bond conjugated to a double bond are described.

专利号:WO-2017021270-A1
优先权日:2015-08-03
标 题 :Process for the synthesis of ravidasvir
发明人：CASTALDI GRAZIANO; BARUTO ALESSANDRO; OLDANI ERMINIO; GABOARDI MAURO
权利人:HC-PHARMA AG
摘要:A process for the synthesis of ravidasvir and intermediates useful in the preparation thereof are disclosed.

专利号:US-2025091989-A1
优先权日:2023-09-19
标 题 :Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-4978744-A
优先权日:1989-01-27
标题:Synthesis of dolastatin 10
发明人：PETTIT GEORGE R; SINGH SHEO B
权利人:UNIV ARIZONA
摘要:A complicated but extremely important scheme of synthesis has been developed for synthesizing, dolaisoleuine, dolaproine, dolaphenine and dolavaline from readily available starting materials such as Z-(S,S)isoleucine, S-phenylalaline, S-phenylalaninol, S-prolinol, S-mandelate, and S-valine. The requisite amino acids have been combined using several peptide coupling procedures to create pharmaceutically pure dolastatin 10.

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-7312343-B2
优先权日:2004-06-02
标 题:Synthesis of α-amino-β-alkoxy-carboxylic acid esters
发明人：SCHMID RUDOLF; ZUTTER ULRICH
权利人:HOFFMANN LA ROCHE
摘要:Compounds of formula I n nand a process for the preparation of such compounds are disclosed.