CAS: 67377-55-3; (R)-N-(1-Phenylethyl)Hydroxylamine
该化合物是一种手性氢氧胺衍生物,其特征是其(R)结构成型的苯基乙基替代成分,该化合物是有机合成的多用途中间体,特别是在制作手性辅助剂,皮条和不对称催化剂方面.其立体化学纯度使该化合物对对应选择性变异具有价值,包括光活胺和氢氧胺衍生物的合成.该化合物在标准条件下的稳定性和与一系列反应条件的兼容性增强了其在制药和精细化学应用中的效用.其结构特征还促进了对立体反应的研究,促进了不对称合成方法的进步.
物理性质
MSDS等安全信息
上下游产品
acetophenone oxime N-α-methyl benzyl-O-benzoyl hydroxylamine hydr°Chloride tin(II) benzenethiolate (1-nitroethyl)benzene N-(1-phenylethyl)-N-hydroxyurea N-ethylidene-1-phenylethanamine N-oxide (+/-)-N-(2-methylpropylidene)-1-phenylethanamine N-oxide N-(α-methylbenzyl)-N-hydroxysuccinamic acid合成工艺路线路线简述
📜2-氨基-2-苯乙酸乙酯 在 Sodium Hydroxide,Disodium Hydrogenphosphate,Lithium Aluminium Tetrahydride体系中,用 四氢呋喃,甲醇作为反应溶剂,反应 3.25H,获得 (R)-1-Phenylethylhydroxylamine
参考文献:Diastereoselectivity Of Organometallic Additions To Nitrones Bearing Stereogenic N-Substituents
标题:Diastereoselectivity Of Organometallic Additions To Nitrones Bearing Stereogenic N-Substituents
摘要:
Doi:10.1021/Jo00298A018
海关参考信息
- 2902600000-乙苯
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专利信息
专利号:US-8084630-B2
优先权日:2007-05-31
标 题 :Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL; TEVA PHARMA
摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.
专利号:US-2009281176-A1
优先权日:2007-11-01
标题:Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
摘要:A process for the preparation of ramelteon and intermediates useful in the process. The process suitable for industrial scale provides increased yield and/or greater purity with fewer process steps.
专利号:WO-2009056993-A2
优先权日:2007-11-01
标题 :A process for the synthesis of ramelteon and its intermediates
专利号:US-2009069581-A1
优先权日:2007-05-31
标题:Process for the synthesis of ramelteon and its intermediates
专利号:EP-2098519-A1
优先权日:2007-05-31
标 题 :Process for the synthesis of ramelteon and its intermediates
专利号:EP-2069320-A2
优先权日:2007-05-31
标 题:Process for the synthesis of ramelteon and its intermediates
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Process For The Synthesis Of Ramelteon And Its Intermediates摘要:A Process For The Preparation Of Ramelteon And Intermediates Useful In The Process. The Process Suitable For Industrial Scale Provides Increased Yield And/or Greater Purity With Fewer Process Steps.
合成参考文献
参考文献:10.1055/s-0035-1561469
摘要:Amat M, Bosch J, Llor N, Guignard G. Synthesis of Fluvirucins and Their Aglycons, the Fluvirucinins. Synthesis. 2016 Jun 23;48(17):2705–20. doi: 10.1055/s-0035-1561469.
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