CAS: 62600-71-9; (R)-2-(3-Chlorophenyl)Oxirane

上下游产品

3-Chlorostyrene (R)-1-(3-chlorophenyl)-2-chloro-1-hydroxyethane 2-bromo-1-(3-chlorophenyl)ethanol (+)-2-chloro-1-(3-chlorophenyl)ethanol -(2R)-2-(3-chlorophenyl)-2-hydroxyethanamineN-(2R)-7-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphth-2-yl-(2R)-2-(3-chlorophenyl)-2-hydroxyethanamine (R)-1-(3-Chloro-phenyl)-2-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethanol Amibegron hydr°Chloride N-[(2(R) 7-methoxy-1,2,3,4-tetrahydronaphth-2-yl)methyl]-(2R)-2-hydroxy-2-(3-chlorophenyl)ethanamine hydr°Chloride

📜3-氯苯乙烯置于n-甲基吲哚酮,Chloro-(R,R)-<<2,2''-<(1,2-Diphenyl-1,2-Ethanediyl)Bis(Nitrilo-Methylidyne)>-Bis<4-Triisopropylsiloxy-6-(1,1-Dimethylethyl)Phenolato>>-N,N'',O,O''>Manganese(Iii),间氯过氧苯甲酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 3.0H,反应生成 (R)-3-氯苯基环氧乙烷
参考文献:通过不对称环氧化-水解动力学拆分序列合成对映体纯的3-氯苯乙烯氧化物
标题:通过不对称环氧化-水解动力学拆分序列合成对映体纯的3-氯苯乙烯氧化物
摘要:使用(salen)co催化的水解动力学拆分(hkr)反应,在> 99%ee的条件下制备3-氯代苯乙烯氧化物.hkr在外消旋和对映体富集的环氧化合物上均成功进行,后者是通过(salen)mn催化的不对称环氧化反应获得的.
DOI:10.1016/s0957-4166(97)00568-5

专利信息

专利号:US-7220870-B2
优先权日:1995-03-14
标 题:Hydrolytic kinetic resolution of cyclic substrates
发明人：JACOBSEN ERIC N; TOKUNAGA MAKOTO; LARROW JAY F
权利人:HARVARD COLLEGE
摘要:The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.

专利号:US-5312961-A
优先权日:1989-02-14
标 题 :2-amino-7-hydroxytetralin carboxylalkyl ethers
发明人：GUZZI UMBERTO; CECCHI ROBERTO; MANARA LUCIANO
权利人:SANOFI ELF
摘要:The invention relates to 2-amino-7-hydroxytetralin carboxyalkyl ethers of formula ##STR1## wherein Alk represents a straight or branched (C 3 -C 5 )alkylene group, and R is hydrogen or (C 1 -C 4 )alkyl, useful as starting materials in the synthesis of 7-substituted phenylethanolaminotetralins of formula (XII) ##STR2## wherein X represents hydrogen, halogen, (C 1 -C 4 )alkyl, or trifluoromethyl which are useful as spasmolytics and anti-glaucoma agents. n The new 7-substituted phenylethanolaminotetralins (XII) as well as the intermediates in the preparation of the compounds (I), the N-protected 2-amino-7-hydroxytetralin carboxyalkyl ethers, are also claimed.

专利号:EP-0383686-B1
优先权日:1989-02-14
标题:2-amino-7-hydroxytetraline carboxyalkyl ethers
摘要:The invention relates to 2-amino-7-hydroxytetralin carboxyalkyl ethers of formula in which Alk represents a straight- or branched-chain alkylene group having 3 to 5 carbon atoms and R is hydrogen or a C1-C4 alkyl group, which are useful as starting materials in the synthesis of 7-substituted phenylethanolaminotetralins of formula (XII) in which X represents hydrogen, halogen or a C1-C4 alkyl or trifluoromethyl group, having spasmolytic activity. The new 7-substituted phenylethanolaminotetralins (XII) as well as the intermediates in the preparation of the compounds (I), the N-protected 2-amino-7-hydroxytetralin carboxyalkyl ethers, are also claimed.

专利号:DE-102006056526-A1
优先权日:2006-11-30
标题:Process for the stereoselective synthesis of chiral epoxides by ADH reduction of alpha-leaving group-substituted ketones and cyclization

专利号:CN-115927276-A
优先权日:2022-08-31
标 题 :Halohydrin dehalogenase mutants and their application in the synthesis of chiral oxazolidinones

专利号:CN-115927276-B
优先权日:2022-08-31
标题 :Halohydrin dehalogenase mutants and their application in the synthesis of chiral oxazolidinones