CAS: 5989-02-6; Loliolid

上下游产品

(S)-actinidiolide hexahydro-3aα,4,5,6,7,7aα (3H) hydroxy-6 phenylseleno-3 trimethyl-4,4,7α benzofurannone-2 (6S,7R,7aS)-7-bromo-6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one (6R,7S,7aR)-7-bromo-6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one

(+/-)-(1-Hydroxy-2,6,6-Trimethyl-2-Cyclohexenyl)Acetic Acid置于吡啶,氯化亚砜,碘,三正丁基氢锡,碳酸氢钠,1,8-二氮杂双环[5.4.0]十一碳-7-烯,三氟乙酸,1,1'-偶氮(氰基环己烷),N-溴代乙酰胺体系中,用 1,4-二氧六环,乙醚,正己烷,水 作为反应溶剂,化学反应 31.0H,反应生成 (-)-地芰普内酯
参考文献:Synthesis Of Loliolide,Actinidiolide,Dihydroactinidiolide,And Aeginetolide Via Cerium Enolate Chemistry
标题:Synthesis Of Loliolide,Actinidiolide,Dihydroactinidiolide,And Aeginetolide Via Cerium Enolate Chemistry
摘要:Loliolide,Aeginetolide,Actinidiolide,And Dihydroactinidiolide Were Synthesized In Racemic Form From A Single Common Intermediate,Prepared Through The 1,2 Addition Of The Cerium Enolate Of Ethyl Acetate To 2,6,6-Trimethylcylohexenone.
DOI:10.1021/jo0611566

专利信息

专利号:US-2014243404-A1
优先权日:2010-09-14
标题 :Unique halogen-induced cyclizations, reagents therefor, and compounds produced thereby
发明人：SNYDER SCOTT ALAN; TREITLER DANIEL S; BRUCKS ALEXANDRIA P; GOLLNER ANDREAS; CHIRIAC MARIA I; WRIGHT NATHAN E; PFLUEGER JASON J; BREAZZANO STEVEN P
权利人:SNYDER SCOTT ALAN; TREITLER DANIEL S; BRUCKS ALEXANDRIA P; GOLLNER ANDREAS; CHIRIAC MARIA I; WRIGHT NATHAN E; PFLUEGER JASON J; BREAZZANO STEVEN P; UNIV COLUMBIA
摘要:This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed. A representative halonium compound of the disclosure is: