CAS: 59-32-5; Chloropyramine

该化合物是一种属于苯并氮类化合物的抗脊髓灰质炎,主要用于其抗过敏性,有效缓解与过敏反应有关的症状,如干热和泌尿素.氯丙胺因阻塞H1肝胺受体,从而降低体内抗体胺的影响而发挥作用.该化合物通常通过口服方式施用,并因其镇静作用而闻名,这可能有助于治疗由于过敏而导致失眠的条件.就其化学结构而言,氯丙胺胺因具有一种环和氯苯基组的特点,有助于其药用活动.它一般都受到良好的调剂,但与许多抗口炎剂一样,它可能会产生诸如嗜睡,干口和眩晕等副作用.与任何药物一样,在医疗监督下使用氯丙胺以避免潜在相互作用和反作用十分重要.

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相似化合物

50331-70-9 1220038-87-8 1220030-90-9

物理性质

MSDS等安全信息

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

2-bromo-pyridine 1-(4-chlorobenzyl)-N2,N2-dimethylethane-1,2-diamineN1-(4-chlorobenzyl)-N2,N2-dimethylethane-1,2-diamine N,N-dimethyl-N'-(pyridine-2-yl)ethane-1,2-diamine N-[(4-chlorophenyl)methyl]pyridin-2-amine

合成工艺路线路线简述

  • 合成目标产物 Chloropyramine 主要起始原料 2-Aminopyridine
  • (文献来源)合成步骤主要原料 2-Aminopyridine
📜(4-氯苄基)-吡啶-2-胺双盐酸盐置于sodium Hydride,甲苯体系中,化学反应生成 氯吡拉敏
参考文献:Process Of Preparing N,N-Dimethyln'-(P-Chlorobenzyl)-N'-(2-Pyridyl)-Ethylenediamine
标题:Process Of Preparing N,N-Dimethyln'-(P-Chlorobenzyl)-N'-(2-Pyridyl)-Ethylenediamine

海关参考信息

专利信息


专利号:WO-2023075715-A1
优先权日:2021-10-26
标题 :A pharmaceutical formulation including leukotriene receptor antagonists and/or leukotriene synthesis inhibitors combined with non-steroidal anti-inflammatory drugs (nsaids)
发明人：OYTUN FARUK; CAN EFE
权利人:VSY BIYOTEKNOLOJI VE ILAC SANAYI ANONIM SIRKETI
摘要:This invention is related to a pharmaceutical formulation including Leukotriene receptor antagonists and/or Leukotriene synthesis inhibitors combined with non-steroidal anti-inflammatory drugs (NSAIDs) and antihistamines in ocular diseases and in inflammatory and allergic diseases for systemic and topical use. The objective of this invention is to create a novel formulation to be effective as much as steroids while having significantly less side effects for long-term use in treating ocular diseases, inflammatory and allergic diseases. In other words our aim is to achieve the inhibition of pro-inflammatory mediators (prostaglandins, thromboxane, histamine and leukotrienes) as much as steroids do with a safer combination.

专利号:CA-3219751-A1
优先权日:2021-05-28
标 题:Process for the synthesis of calebin-a and its intermediates

专利号:RU-2141483-C1
优先权日:1997-07-04
标题 :Peptide derivatives or their pharmaceutically acceptable salts, method of their synthesis, use and pharmaceutical composition

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主要参考文献


1: Kurenova EV, Hunt DL, He D, Magis AT, Ostrov DA, Cance WG. Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo. J Med Chem. 2009 Aug 13;52(15):4716-24. doi: 10.1021/jm900159g.
2: Durand-Arczynska W, Schoenenweid F, Durand J. Effects of chloropyramine, dimethindene and diphenhydramine on transepithelial ion transport: studies in bovine tracheal epithelium and frog skin. J Physiol (Paris). 1986;81(3):185-90. German.

合成参考文献


摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
参考文献:10.1186/s12876-021-01876-5
摘要:Homolak J, Nikolić M, Potoč D, Živković M, Bakula D, Budimir I, Pavić I, Hrabar D, Ljubičić N, Vražić D. The onset of ulcerative colitis upon Helicobacter pylori eradication in a 72-year-old woman: report of a rare case with a 3-year follow-up. BMC Gastroenterology. 2021 Jul 31;21(1):303. doi: 10.1186/s12876-021-01876-5.
参考文献:10.1007/bf01988006
摘要:Nowak JZ, Maslinski C. 3H-mepyramine binding and histamine-stimulated cAMP accumulation in mammalian retina. Agents Actions. 1986 Apr;18(1-2):145–8. doi: 10.1007/bf01988006.
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