CAS: 54063-53-5; 1-(2-(2-Hydroxy-3-(Propylamino)Propoxy)Phenyl)-3-Phenylpropan-1-One

上下游产品

propafenone propylamine diethyl diazodicarboxylate 2'-hydroxy-3-phenylpropiophenone(R)-propafenone (S)-propafenone 1-{(R)-2-Hydroxy-3-[2-(3-phenyl-propionyl)-phenoxy]-propyl}-3-((R)-1-phenyl-ethyl)-1-propyl-urea 1-{(S)-2-Hydroxy-3-[2-(3-phenyl-propionyl)-phenoxy]-propyl}-3-((R)-1-phenyl-ethyl)-1-propyl-urea

1-(2'-羟基苯基)丙-2-烯-1-醇,苯肼置于3,4,7,8-四甲基-1,10-菲罗啉,Bis(Dibenzylideneacetone)-Palladium(0)体系中,用 乙腈 作为反应溶剂,化学反应 23.0H,反应生成 1-[2-[2-羟基-3-(丙氨基)-丙氧基]苯基]-3-苯基-1-丙酮
参考文献:钯催化芳肼与烯丙醇通过 C-N 键断裂的氧化非经典 Heck 反应:获得 β-芳基化羰基化合物
标题:钯催化芳肼与烯丙醇通过 C-N 键断裂的氧化非经典 Heck 反应:获得 β-芳基化羰基化合物
摘要:已经成功地开发了一种有效的钯催化的芳基肼与烯丙醇通过 C-N 键断裂的氧化非经典 Heck 反应.该方法在无碱,简单和温和的露天反应条件下提供了一系列具有广泛官能团耐受性的β-芳基化羰基化合物.在该反应中,离去基团分子量较小的芳基肼被用作"绿色"芳基化试剂,在空气中释放出副产物n 2和水.机理研究表明,涉及芳基自由基过程和 Pd-H 复合迁移重新插入.此外,抗心律失常药物普罗帕酮的合成以该转化为关键步骤完成.
DOI:10.1021/acs.Joc.2C01115

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

专利号:US-2015158809-A9
优先权日:2013-02-26
标 题 :Method of making 1-(acyloxy)-alkyl carbamate compounds
发明人：WANG HUAN; LIU PENG; DAI QUNYING; YIN HAO; RAILLARD STEPHEN P
权利人:XENOPORT INC
摘要:Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.

专利号:US-9556123-B2
优先权日:2004-07-19
标题:Synthesis of triethylenetetramines
发明人：JONAS MARCO; VAULONT IRENE; SOI ANTONIO; SCHMIDT GUNTHER
权利人:PHILERA NEW ZEALAND LTD
摘要:Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.

专利号:US-9550000-B2
优先权日:2011-09-09
标题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：ROBINSON SIMON P; YU MING
权利人:ROBINSON SIMON P; YU MING; LANTHEUS MEDICAL IMAGING INC
摘要:The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.