CAS: 530-43-8; (2R,3R)-2-(2,2-Dichloroacetamido)-3-Hydroxy-3-(4-Nitrophenyl)Propyl Palmitate

该化合物是氯苯酚(一种广谱抗生素)的酯衍生物,主要用于治疗细菌感染,特别是儿科药物,因为其棕榈脂形态增加了其溶性,并吸收到胃肠道中,该物质似乎是白的,是白的,一般以口服配方方式施用.氯苯酚棕榈酸盐的特点是,它能够抑制细菌蛋白合成,将其与50S血清亚元素捆绑在一起,使其对各种克抗药性和克阴性细菌有效.但是,由于潜在副作用,包括肿瘤贫血和灰色婴儿综合症在新生儿体内的风险,该物质的使用受到限制.由于这些安全考虑,该化合物还受到许多国家的严格管制.适当的储存条件对于保持其稳定性至关重要,应将其保存在一个冷干的地方,远离光线.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

dichloroacetic acid methyl ester R,2R)-2-amino-1-(4-nitro-phenyl)-3-palmitoyloxy-propan-1-ol(1R,2R)-2-amino-1-(4-nitro-phenyl)-3-palmitoyloxy-propan-1-ol R,2R)-2-amino-1-(4-nitro-phenyl)-3-palmitoyloxy-propan-1-ol; hydr°Chloride(1R,2R)-2-amino-1-(4-nitro-phenyl)-3-palmitoyloxy-propan-1-ol; hydr°Chloride dichloroacetic anhydridechloramphenicol 1-hexadecylcarboxylic acid

合成工艺路线路线简述

    📜[r(R*,R*)]-2-(苄亚基氨基)-1-(4-硝基苯基)丙烷-1,3-二醇置于吡啶,甲醇,N,N-二甲基甲酰胺体系中,化学反应生成 氯霉素棕榈酸酯
    参考文献:Long Chain Esters Of Nitrophenylaminopropanediols And Preparation Thereof
    标题:Long Chain Esters Of Nitrophenylaminopropanediols And Preparation Thereof

    海关参考信息

    专利信息


    专利号:US-9693999-B2
    优先权日:2011-01-26
    标题:Small molecule RNase inhibitors and methods of use
    发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
    权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
    摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

    专利号:WO-2009056955-A1
    优先权日:2007-10-30
    标题 :Amine-bearing phospholipids (abps), their synthesis and use
    发明人:ZUMBUEHL ANDREAS
    权利人:UNIV BASEL; ZUMBUEHL ANDREAS
    摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

    专利号:US-9868747-B2
    优先权日:2014-02-18
    标题:Marinopyrrole derivatives and methods of making and using same
    发明人:LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI
    权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD
    摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.

    专利号:US-6911318-B2
    优先权日:1999-03-03
    标 题:Bacterial transglycosylases: assays for monitoring the activity using Lipid II substrate analogs and methods for discovering new antibiotics
    发明人:KAHNE SUZANNE WALKER
    权利人:UNIV PRINCETON
    摘要:This invention provides a direct method for monitoring bacterial transglycosylase activity using labeled substrates produced by chemo-enzymatic synthesis wherein the labels are selected to permit the detection of both polymeric and non-polymeric products simultaneously, either directly or following the separation of product from starting material. The invention promotes the discovery of new antibiotics with activity against bacterial transglycosylases by a) laying the groundwork for structural analysis of purified, active transglycosylase (which permits structure-based design); and b) providing an assay that can be used to screen for inhibitors.

    专利号:CN-106478471-B
    优先权日:2016-10-11
    标 题:A kind of synthesis technique of chiral tertiary butylsulfinamide

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1111/j.1600-0773.1986.tb00063.x
    摘要:Pradhan A, Majumdar MK. Metabolism of some drugs by intestinal lactobacilli and their toxicological considerations. Acta Pharmacol Toxicol (Copenh). 1986 Jan;58(1):11–5. doi: 10.1111/j.1600-0773.1986.tb00063.x.
    摘要:Drugs in Japan, 6(248), 1982
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