专利号:US-4422970-A 优先权日:1982-05-20 标题 :Method of synthesis of 1-dodecylazacycloheptan-2-one 发明人:RAJADHYAKSHA VITHAL J; PECK JAMES V; MINASKANIAN GEVORK 权利人:NELSON RES & DEV 摘要:In a method of synthesis of 1-substituted azacycloalkan-2-ones with primary alkyl halides and aralkyl halides as alkylating agents, the improvement comprising carrying out the N-alkylation in the presence of a phase transfer catalyst having the structural formula where X is suitable anion; and R1, R2, R3 and R4 are each alkyl or aralkyl groups having 1-18 carbon atoms, or R2, R3 and R4 can form a part of a heterocyclic ring, with the proviso that the combined total of carbon atoms is between 16 and 40.
专利号:WO-2013113319-A1 优先权日:2012-01-31 标题 :Process for the preparation of strontium ranelate, intermediate or hydrates thereof 发明人:KOFTIS THEOCHARIS V; ROHIT RAVIKANT SONI; BHARAT BECHARBHAI BODA; DIPAKKUMAR NARSIBHAI BHUT; VIMALKUMAR SUBHIRBHAI PATEL 权利人:PHARMATHEN SA; KOFTIS THEOCHARIS V; ROHIT RAVIKANT SONI; BHARAT BECHARBHAI BODA; DIPAKKUMAR NARSIBHAI BHUT; VIMALKUMAR SUBHIRBHAI PATEL 摘要:The present invention relates to an improved process for the synthesis of strontium ranelate compound of formula I or its hydrates thereof. More particularly, the present invention relates to an economically viable and industrially feasible process for the preparation of strontium ranelate, intermediate or its hydrates thereof.
专利号:US-2008214386-A1 优先权日:2004-03-01 标题:Catalyst for Cyclic Carbonate Synthesis 发明人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU 权利人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU 摘要:Provided are a solid catalyst which gives a cyclic carbonate at a high yield and a high selectivity, which is stable and which may be readily separated after reaction; and a method of industrially advantageous, inexpensive and safe production of a cyclic carbonate by the use of the catalyst. The catalyst contains an inorganic solid substance having a surface modified with an ionic substance containing a Group 15 element; or contains an ionic substance containing a Group 15 element, and an inorganic solid substance. The modifying group for surface modification of an inorganic solid substance is an ionic substance containing a Group 15 element. The ionic substance containing a Group 15 element is at least one substance selected from organic phosphonium salts, organic ammonium salts, organic arsonium salts and organic antimonium salts.
专利号:RU-2014322-C1 优先权日:1990-12-07 标 题:Method of synthesis of dimethyl-2-difluoromethyl-4-(2-methylpropyl)- 6-trifluoromethyl-3,5-pyridinedicarbothioate
专利号:EP-0095096-A2 优先权日:1982-05-20 标题 :Improved method of synthesis of 1-substituted azacycloalkan-2-ones
专利号:EP-0095096-B1 优先权日:1982-05-20 标 题:Improved method of synthesis of 1-substituted azacycloalkan-2-ones
参考文献:10.1007/s00424-012-1207-7 摘要:Pouokam E, Bader S, Brück B, Schmidt B, Diener M. ATP-sensitive K+ channels in rat colonic epithelium. Pflügers Archiv - European Journal of Physiology. 2012 Dec 22;465(6):865–77. doi: 10.1007/s00424-012-1207-7.