CAS: 4845-99-2; Brucine Sulfate

专利信息

专利号:US-7141238-B2
优先权日:1998-04-02
标题:Compositions for reducing UV-induced inhibition of collagen biosynthesis in human skin
发明人：FISHER GARY J; VOORHEES JOHN J
权利人:UNIV MICHIGAN
摘要:Exposure of human skin to ultraviolet (UV) radiation from the sun not only induces the production of enzymes (matrix metalloproteinases) that degrade collagen, but also inhibits the synthesis of new collagen by inhibiting the synthesis of procollagen. This UV-induced inhibition of the synthesis of collagen can be prevented by the topical application of a retinoid or c-JUN inhibitor to the skin prior to exposure to UV radiation.

专利号:WO-9951220-A1
优先权日:1998-04-02
标题:Methods and compositions for reducing uv-induced inhibition of collagen synthesis in human skin

专利号:US-6919072-B2
优先权日:1997-02-25
标题:Methods and compositions for reducing collagen loss due to chronological aging in human skin
发明人：VARANI JAMES; FISHER GARY J; VOORHEES JOHN J; KANG SEWON
权利人:UNIV MICHIGAN
摘要:Chronological aging of human skin can be delayed with the topical application of an MMP inhibitor, preferably a retinoid (an indirect MMP inhbitor); retinoids also normalize procollagen biosynthesis. Chronological aging, or natural aging, is evidenced in elderly (80+ years old) skin by increased MMP levels and decreased procollagen levels when compared with younger individuals. Prophylactic treatment of not yet chronologically-aged skin with a retinoid both inhibits degradation of dermal collagen and restores procollagen synthesis. Biopsied sections from elderly skin show that a single treatment of chronologically-aged skin with a retinoid can increase epidermal thickness, improve the dermal collagen density, and promote the formation of rete pegs and dermal papillae. Such benefits are helpful in preventing bruising, tearing, and ulceration of elderly skin. Accordingly, prophylactic treatment begun much earlier in life with an MMP inhibitor and/or a retinoid delays the onset of such symptoms.

专利号:WO-9951220-A9
优先权日:1998-04-02
标题:Methods and compositions for reducing uv-induced inhibition of collagen synthesis in human skin

专利号:EP-1067920-A1
优先权日:1998-04-02
标题 :Methods and compositions for reducing uv-induced inhibition of collagen synthesis in human skin

专利号:CN-1303282-A
优先权日:1998-04-02
标题:Methods and compositions for reducing ultraviolet-induced inhibition of collagen synthesis in human skin