CAS: 437-64-9; 5-Hydroxy-2-(4-Hydroxyphenyl)-7-Methoxy-4H-Chromen-4-One

该化合物是主要在各种植物中发现的氟氯素化合物,特别是*索福拉*,其特点是黄色晶体外观,以潜在的生物活动闻名,包括抗氧化剂,抗炎和抗微生物特性.根克瓦宁展示了一种氟氯素结构,这是一种以苯丙酮脊椎为特征的氟氯素.这种化合物溶于有机溶剂,但水溶性有限.根克瓦宁由于其潜在的治疗作用,包括它在改变各种生物化学途径方面的作用,因此对药理学研究产生了兴趣.此外,它可能有助于与植物饮食消费相关的健康利益.其安全性特征和人类功效仍然是正在进行的研究的主题,突出表明需要进一步研究,以充分了解其生物影响和医药和营养的潜在应用.

结构式图片

欧盟法规

C&L通报

上下游产品

5,4'-dihydroxy-7-methoxyflavanone 3-(4-hydroxyphenyl)-5,7-dimethoxy-4H-chromen-4-one 2-(4-benzyloxy-phenyl)-5-hydroxy-7-methoxy-chromen-4-one protogenkwanin 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one 5-benzoyloxy-2-(4-benzoyloxy-phenyl)-7-methoxy-chromen-4-one 4',5,-diacetoxy-7-methoxyflavone protogenkwanone

合成工艺路线路线简述

    📜Naringin置于吡啶,4-二甲氨基吡啶,Candida Antarctica Lipase B,硫酸,碘,Sodium Methylate,Caesium Carbonate体系中,用 四氢呋喃,甲醇,水,二甲基亚砜,异丙醇 作为反应溶剂,化学反应 97.17H,反应生成 4',5-二羟基-7-甲氧基黄酮
    参考文献:Site-Selective Synthesis Of Acacetin And Genkwanin Through Lipase-Catalyzed Deacetylation Of Apigenin 5,7-Diacetate And Subsequent Methylation
    标题:Site-Selective Synthesis Of Acacetin And Genkwanin Through Lipase-Catalyzed Deacetylation Of Apigenin 5,7-Diacetate And Subsequent Methylation
    摘要:
    DOI:10.3987/com-18-S(F)17

    海关参考信息

    专利信息


    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

    专利号:CN-111039910-A
    优先权日:2019-12-31
    标题 :A kind of method and application of photo-initiated synthesis of 3-aryl flavonoids or coumarin compounds

    专利号:CN-117837498-A
    优先权日:2024-01-25
    标题 :Method for improving and regulating synthesis of flavonoids in saussurea involucrata leaves

    专利号:US-7842721-B2
    优先权日:2007-08-24
    标题:Composition for treating cancer cells and synthetic method for the same
    发明人:LIN AN-SHEN; WU YANG-CHANG; LEE KUO-HSIUNG; CHANG FANG-RONG
    权利人:UNIV KAOHSIUNG MEDICAL
    摘要:A pharmaceutical composition having a cytotoxic effect to a cancer cell is provided. The pharmaceutical composition includes a flavonoid compound having a formula as n nwherein B ring is a 4-oxo-cyclohexa-2,5-dienyl group, and any one of R 1 -R 12 is one selected from a group consisting of hydrogen group, hydroxyl group, C1-C20 alkyl group, C1-C20 ether group, C1-C20 ester group, carboxyl group, halogen and sugar. The flavonoid compound is obtained from a chemical method being one of a total synthesis method and a semi-synthesis method.

    专利号:CN-115612114-A
    优先权日:2021-07-14
    标 题:Method and application of copolymer film and its enzymatic self-assembly synthesis

    专利号:CN-114146084-A
    优先权日:2021-12-10
    标 题 :Application of davidin as a novel coronavirus inhibitor and its synthesis method

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    参考文献:10.1007/bf02976369
    摘要:Jeong HJ, Shin YG, Kim IH, Pezzuto JM. Inhibition of aromatase activity by flavonoids. Arch Pharm Res. 1999 Jun;22(3):309–12. doi: 10.1007/bf02976369.
    参考文献:10.1007/s00253-018-9043-0
    摘要:Berim A, Gang DR. Production of methoxylated flavonoids in yeast using ring A hydroxylases and flavonoid O-methyltransferases from sweet basil. Applied Microbiology and Biotechnology. 2018 Apr 28;102(13):5585–98. doi: 10.1007/s00253-018-9043-0.
    参考文献:10.1016/0006-2952(94)90291-7
    摘要:Fesen MR, Pommier Y, Leteurtre F, Hiroguchi S, Yung J, Kohn KW. Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem Pharmacol. 1994 Aug 03;48(3):595–608. doi: 10.1016/0006-2952(94)90291-7.
    参考文献:10.1021/jm800115x
    摘要:Lo Piparo E, Scheib H, Frei N, Williamson G, Grigorov M, Chou CJ. Flavonoids for controlling starch digestion: structural requirements for inhibiting human alpha-amylase. J Med Chem. 2008 Jun 26;51(12):3555–61. doi: 10.1021/jm800115x.
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