专利号:WO-2024089225-A1 优先权日:2022-10-28 标题 :Process for the synthesis of methoxy substituted benzaldehyde compounds 发明人:MAYWALD MATTHIAS; VETTIGER THOMAS; GRIBKOV DENIS; TESSON JULIA 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention provides, inter alia, a process for preparing a compound of formula (I) wherein the substituents are as defined in claim 1.
专利号:US-8692026-B2 优先权日:2010-07-15 标题:Processes for producing 4-bromo-2-methoxybenzaldehyde 发明人:GIARD THIERRY J; MUTTERER VINCENT L; DURVAUX CHRISTOPHE 权利人:GIARD THIERRY J; MUTTERER VINCENT L; DURVAUX CHRISTOPHE; ALBEMARLE CORP 摘要:A new synthesis of 4-bromo-2-methoxybenzaldehyde is reported from 1,4 dibromo 2-fluorobenzene. First, 2-fluoro-4-bromobenzaldehyde is prepared through metal halogen exchange and formylation with a formyl source at 0° C. After crystallization, this intermediate is reacted with methanol in the presence of potassium carbonate. Subsequently, 4-bromo-2-methoxy-benzaldehyde is crystallized.
专利号:EP-4573100-A1 优先权日:2022-08-16 标题:Synthesis of substituted 1-aryl-1'-heteroaryl compounds and substituted 1,1'-biheteroaryl compounds, and analogues thereof
专利号:EP-4608796-A1 优先权日:2022-10-28 标 题 :Process for the synthesis of methoxy substituted benzaldehyde compounds
专利号:CN-119731185-A 优先权日:2022-08-16 标 题 :Synthesis of substituted 1-aryl-1'-heteroaryl compounds and substituted 1,1'-bisheteroaryl compounds and their analogs
专利号:WO-2024038356-A1 优先权日:2022-08-16 标 题:Synthesis of substituted 1-aryl-1'-heteroaryl compounds and substituted 1,1'-biheteroaryl compounds, and analogues thereof 发明人:COLE ANDREW G; MASON JEREMY; NGUYEN DUYAN; OZTURK SEYMA; PALLERLA MAHESH KUMAR; PAMULAPATI GANAPATI REDDY; SPINK JAN MICHELLE 权利人:ARBUTUS BIOPHARMA CORP 摘要:The present disclosure includes synthetic methods for preparing certain substituted 1-aryl-1'-heteroaryl and 1,1'-biheteroaryl compounds, which can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) infections in a patient, in particular compound 2-((6-(2-chloro- 3-(3-chloro-2-(3-methoxy-4-((7-oxo-2,6-diazaspiro[3.4]octan-2yl)methyl)phenyl)pyridin-4-yl)phenyl)-2-methoxypyridin-3-yl)methyl)-2,6- diazaspiro[3.4]octan-7-one.
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合成参考文献
参考文献:10.1007/s10895-024-03856-w 摘要:Zhang Y, Feng T, Hu T, Wang Y, Le Y. A New Phenothiazine-Based Fluorescent Probe for Rapid and Specific Detection of Fluoride. J Fluoresc. 2025 Jun;35(6):4513–20. doi: 10.1007/s10895-024-03856-w.