CAS: 332012-40-5; 4-(((4-((4-Chlorophenyl)Amino)Furo[2,3-D]Pyridazin-7-yl)Oxy)Methyl)-N-Methylpicolinamide

上下游产品

N-Methylformamide 4-(hydroxymethyl)-N-methylpyridine-2-carboxamide 4-chloroanilino-7-chlorofuro[2,3-d]pyridazine 4-chloro-7-[N-(4-chlorophenyl)amino]-[2,3-d]furopyridazine4-[({4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide 4-methylbenzenesulfonate 4-[({4-[(4-chlorophenyl)amino]furan[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide methanesulfonate

📜2-甲基氨基甲酰异烟酸乙酯置于氢氧化钾,Sodium Tetrahydroborate,18-冠醚-6体系中,用 乙醇,甲苯 用作溶剂,化学反应 18.0H,反应生成替拉替尼
参考文献:Substituted Pyridines And Pyridazines With Angiogenesis Inhibiting Activity
标题:Substituted Pyridines And Pyridazines With Angiogenesis Inhibiting Activity
摘要:具有抑制血管生成活性的取代吡啶并呈现广义结构式的物质,其中包含a,B,D,E和l的环为苯或含氮杂环;基团x和y可以是多种定义的连接单元中的任意一种;R1和r2可以是定义独立取代基,或者一起可以是环定义的桥;环j可以是芳基,吡啶基或环烷基基团;G基团可以是多种定义的取代基之一.还公开了含有这些物质的药物组合物,以及使用这些物质治疗具有异常血管生成或高渗透性过程特征的哺乳动物的方法.

专利信息

专利号:US-2024400576-A1
优先权日:2021-09-03
标 题:Nitrogen-containing derivatives of salinomycin, synthesis and uses thereof
发明人：RODRIGUEZ RAPHAËL; CZERWONKA DOMINIKA; ANTOSZCZAK MICHAL; HUCZYNSKI ADAM
权利人:CENTRE NAT RECH SCIENT; INST CURIE; INST NAT SANTE RECH MED; ADAM MICKIEWICZ UNIV
摘要:The present invention relates to nitrogen-containing derivatives of salinomycin having the formula (I), as well as pharmaceutically acceptable salt thereof, and synthesis and uses thereof, in particular for the treatment and/or prevention of cancer including for preventing cancer metastasis and/or for preventing cancer recurrence and/or for decreasing resistance to a chemotherapy in a subject.

专利号:US-2025250280-A1
优先权日:2021-09-03
标 题 :Nitrogen-containing derivatives of narasin, synthesis and uses thereof
发明人：RODRIGUEZ RAPHAËL; CAÑEQUE TATIANA; MÃœLLER SEBASTIAN; ANTOSZCZAK MICHAL
权利人:CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; INST CURIE
摘要:The present invention relates to nitrogen-containing derivatives of narasin having the formula (I), as well as synthesis and uses thereof, in particular for the treatment and/or prevention of cancer. Also disclosed are medicaments including the nitrogen-containing derivatives of narasin, which include medicaments for preventing cancer metastasis and/or for preventing cancer recurrence and/or for decreasing resistance to a chemotherapy in a subject.

专利号:US-9295731-B2
优先权日:2013-04-01
标题 :Cleavable drug conjugates, compositions thereof and methods of use
发明人：NGUYEN MARK QUANG
权利人:NGUYEN MARK QUANG
摘要:Base-labile crosslinkers, base-labile conjugates comprising such crosslinkers, methods of their synthesis and use are disclosed.

专利号:WO-2023031399-A1
优先权日:2021-09-03
标题 :Iron-activable nitrogen-containing derivatives of salinomycin and narasin, synthesis and use for the treatment of cancers

专利号:WO-2023031402-A1
优先权日:2021-09-03
标 题 :Nitrogen-containing derivatives of salinomycin, synthesis and uses thereof

专利号:WO-2023031362-A1
优先权日:2021-09-03
标题:Nitrogen-containing derivatives of narasin, synthesis and uses thereof