CAS: 3257-18-9; Z-Cys(Bzl)-Oh

该化合物是一种合成氨酸衍生物,具有合成氨基酸衍生物,具有经苯氧碳基(Pmc)保护组和苯甲基苯甲基联苯的脊椎,具有保护组和侧链的功能.该化合物的特征是其个性中心,它有助于其潜在的生物活动和与酶或受体互动的特殊性.苯氧组的存在会增强其亲脂性,有可能影响其溶性及生物系统中的渗透性.此外,保有硅酸的硫醇组(-SH),能够产生对蛋白结构和功能至关重要的复毒反应和脱硫联结.该化合物可被用于合成,药物开发或因其独特的结构特征而成为生物化学探测器.其稳定性,再活性以及与其他生物分子的相互作用,可能会受到诸如pH和生物化学研究中的环境因素的影响.

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合成工艺路线路线简述

    📜N-苄氧羰基-S-苄基-L-半胱氨酸甲酯置于甲醇,Sodium Hydroxide体系中,化学反应生成 N-苄氧羰基-S-苄基-L-半胱氨酸
    参考文献:Transformation Of Serine To Cysteine. β-Elimination Reactions In Serine Derivatives
    标题:Transformation Of Serine To Cysteine. β-Elimination Reactions In Serine Derivatives
    摘要:
    DOI:10.1021/ja00891A019

    海关参考信息

    专利信息


    专利号:US-3396157-A
    优先权日:1964-12-01
    标 题:Use of esters of nu, nu-dialkylhydroxylamines and 1-hydroxypiperidine for the synthesis of peptides and other amides
    发明人:TYNDALE YOUNG GEOFFREY; ONSLOW HANDFORD BRIAN
    权利人:NAT RES DEV

    专利号:US-3933783-A
    优先权日:1971-12-27
    标 题 :Formation of peptide bonds in the presence of isonitriles
    发明人:YASUDA NAOHIKO; ARIYOSHI YASUO; TOI KOJI
    权利人:AJINOMOTO KK
    摘要:Amino acids having masked amino groups react with amino acids having masked carboxyl groups to form peptide derivatives in good yields if the reaction medium contains an isonitrile. Isonitriles also are effective in causing condensation of amino acids having masked amino groups with compounds having active hydroxyl groups to the corresponding amino acid esters. The yields of the first-mentioned reaction are enhanced if the reaction mixture additionally contains one of the compounds having active hydroxyl groups. Both the peptide derivatives and the amino acid esters of the compounds having active hydroxyl groups are useful for peptide synthesis.

    专利号:US-3984417-A
    优先权日:1971-12-27
    标题:Method of producing active amino acid esters
    发明人:YASUDA NAOHIKO; ARIYOSHI YASUO; TOI KOJI
    权利人:AJINOMOTO KK
    摘要:Amino acids having masked amino groups react with amino acids having masked carboxyl groups to form peptide derivatives in good yields if the reaction medium contains an isonitrile. Isonitriles also are effective in causing condensation of amino acids having masked amino groups with compounds having active hydroxyl groups to the corresponding amino acid esters. The yields of the first-mentioned reaction are enhanced if the reaction mixture additionally contains one of the compounds having active hydroxyl groups. Both the peptide derivatives and the amino acid esters of the compounds having active hydroxyl groups are useful for peptide synthesis.

    专利号:US-3721662-A
    优先权日:1967-02-04
    标题:Method for producing an active carboxylic acid ester
    发明人:FUJINO M; HTANAKA C
    权利人:TAKEDA CHEMICAL INDUSTRIES LTD
    摘要:AN ACTIVE CARBOXYLIC ACID ESTER OF THE FORMULA 1-(R-COO-),2,3,4,5,6-(CL)5-BENZENE USEFUL IN THE SYNTHESIS OF PEPTIDE, IS PREPARED BY REACTING FORMIC ACID, CERTAIN HYDROCARBON-CARBOXYLIC ACIDS, N-PROTECTED AMINO ACIDS OR A PEPTIDE WITH PROTECTED TERMINAL AMINO GROUP WITH PENTACHLOROPHENYL DICHLOROACETATE OR PENTACHLOROPHENYL TRICHLOROACETATE, IN THE PRESENCE OF A TERTIARY AMINE OR DICYCLOHEXYLAINE.

    专利号:US-9217012-B2
    优先权日:2009-04-08
    标题 :Inhibitors of protein tyrosine phosphatases
    发明人:ZHANG ZHONG-YIN; ZHANG SHENG
    权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
    摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

    专利号:GB-791791-A
    优先权日:1955-03-29
    标 题:A process for the synthesis of peptides

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1007/978-3-642-97886-9_8
    摘要:Bodanszky M. Racemization. 1988. In: Peptide Chemistry.
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