CAS: 27025-41-8; (2S,2'S)-5,5'-(((2R,2'R)-Disulfanediylbis(1-((Carboxymethyl)Amino)-1-Oxopropane-3,2-Diyl))Bis(Azanediyl))Bis(2-Amino-5-Oxopentanoic Acid)

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N-(N-L-γ-谷氨酰基-S-亚硝基-L-半胱氨酰----甘氨酸置于cu2O体系中,化学反应 0.75H,反应生成L-谷胱甘肽 (氧化型)
参考文献:晶面依赖性脱亚硝基化:Cu2O 多晶型物调节 S-亚硝基硫醇中 No 的释放†
标题:晶面依赖性脱亚硝基化:Cu2O 多晶型物调节 S-亚硝基硫醇中 No 的释放†
摘要:一氧化氮 (No) 是一氧化氮合酶 (Nos) 产生的气态小分子,在信号转导中发挥着关键作用.许多蛋白质和小分子中存在的硫醇基团经历亚硝基化形成相应的s-亚硝基硫醇.从s-亚硝基硫醇中释放 No是维持生物系统中 No 水平的关键策略.然而,在生理ph下控制亚硝基化化合物释放no仍然是一个挑战.在本文中,我们描述了cu 2 O纳米材料的合成和no释放能力,并首次提供了实验证据,证明同一晶系内具有不同晶面的纳米晶体对s-亚硝基硫醇表现出不同的活性.我们使用各种成像技术和时间依赖性光谱测量来了解表面反应中涉及的催化活性物质的性质.Cu 2 O的脱亚硝基化反应可以进行多次而不影响催化活性.
Doi:10.1039/c9Sc01374A

专利信息

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

专利号:US-6548276-B2
优先权日:2000-09-06
标题:Enhanced in vitro synthesis of active proteins containing disulfide bonds
发明人：SWARTZ JAMES ROBERT; KIM DONG-MYUNG
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.

专利号:US-7691968-B2
优先权日:2002-05-03
标题:Process for the synthesis of peptides amides by side-chain attachment to a solid phase
发明人：EVANS DAVID JOHN; SIMPKIN DEAN STEVEN ANTHONY; WELLINGS DONALD ALFRED; ATHERTON ERIC
权利人:AVECIA BIOLOG LTD
摘要:A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching an α-nitrogen protected Cα-carboxamide amino acid to a solid support by its side chain, removing the α-nitrogen protecting group, assembling a peptide chain on said α-nitrogen and then cleaving the assembled peptide amide from the solid support. Novel amino acid analogues, peptide amides and solid-phase supports are also provided.

专利号:US-7871794-B2
优先权日:2007-01-18
标 题:Enhanced cell-free synthesis of active proteins containing disulfide bonds
发明人：KNAPP KURTIS G; SWARTZ JAMES ROBERT
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of active polypeptides containing disulfide bonds. In certain embodiments of the invention, the reaction mix includes a biological extract derived from a bacterial cell in which the glutathione reductase gene has been inactivated, which is pre-treated with a low concentration of a sulfhydryl inactivating agent.

专利号:US-RE40849-E
优先权日:1998-04-30
标题:Method of treatment of glutathione deficient mammals
发明人：KELLER ROBERT H; KIRCHENBAUM DAVID W
权利人:VIT IMMUNE L C
摘要:Glutathione (GSH) is a tripeptide of extreme importance as a catalyst, reductan, and reactant. It can be depleted intracellulary either by forming a direct complex with an electrophilic agent (accomplished investigationally by agents such as bromobenzene or diethyl maleate), by way of inhibition of synthesis, or by subjecting cells to oxidant stress. Most cells, except for epithelia cells, do not have a direct transport capacity for intact GSH. Non-epithelial cells must either transport precursor substrates for GSH synthesis or salvage amino acids from circulating GSH for reuse in intracellular resynthesis. Dietary cysteine is a rate limiting substrate for the synthesis of glutathione and also inhibits GSH efflux. Although GSH is synthesized from precursors in virtually all cells, the liver is the main source of plasma GSH. Protection and support of liver function is paramount to elevating GSH levels. The disclosure is also of a unique combination of nutritional supplements including n-acetyl cysteine, vitamin C, l-glucosamine, n-acetyl d-glucosamine, quercitin, sylimarin, Alpha lipoic acid and high protein, low fat whey that are combined to support various bodily systems involved in glutathione synthesis, reutilization and storage; all intended to elevate glutathione concentration in the mammalian cell.