CAS: 25717-80-0; (Ethoxycarbonyl)(3-Morpholino-1,2,3-Oxadiazol-3-Ium-5-yl)Amide

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CAS号541-41-3 氯甲酸乙酯 | CAS号16142-27-1 5-氨基-3-(4-吗啉基)-... | CAS号110-91-8 吗啉

📜4-Lithiomolsidomine置于水体系中,用100%的收率获得吗多明
参考文献:衍生自sydnone亚胺(如molsidomine)的阴离子n-杂环卡宾.与硒,钯和金的诱捕反应
标题:衍生自sydnone亚胺(如molsidomine)的阴离子n-杂环卡宾.与硒,钯和金的诱捕反应
摘要:Sydnone亚胺的molsidomine和5-(苯甲酰亚氨基)-3-(2-甲氧基苯基)-1,2,3-恶二唑-2-胺在c4脱质子化后得到阴离子n-杂环卡宾,以甲基化硒加合物,金配合物的形式被捕集(x射线分析)以及钯配合物(x射线分析).卡宾碳原子的13 C NMR共振频率向高场偏移,并且出现在δ = 142.1 Ppm(莫西多明卡宾)和δ = 159.8 Ppm(亚砜亚胺卡宾)上.Pd配合物在suzuki-Miyaura和sonogashira-Hagihara交叉偶联反应中用作催化剂.
Doi:10.1016/j.Tet.2017.07.032

专利信息

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-6277891-B1
优先权日:1997-07-11
标题:Nitric oxide inhibits rhinovirus infection
发明人：SANDERS SCHERER P; PROUD DAVID
权利人:UNIV JOHNS HOPKINS
摘要:Nitric oxide generating compounds or compounds which induce in situ synthesis of nitric oxide can be used to inhibit rhinovirus infection. Nitric oxide has the ability to inhibit both viral replication as well as the synthesis of cytokines, in particular the proinflammatory cytokines. Thus the symptoms of rhinovirus infections can be ameliorated by treatments to increase nitric oxide in the respiratory tract.

专利号:US-7723370-B2
优先权日:2005-07-29
标题:1, 2-diaryl pyrazoles useful as analgetic and antiinflammatory agents
发明人：FISCHER JANOS; KIS-VARGA ISTVANNE; SZABO GYOERGY; LEIBINGER JANOS
权利人:RICHTER GEDEON VEGYESZET
摘要:The present invention relates to new compounds of formula (I), (I) wherein the meaning of R 1 is hydrogen atom, C 1 -C 5 acyl group, benzoyl group or R 2 —COOR 3 group, Y is hydrogen atom or alkali ion, R 2 is C 1 -C 4 straight or branched alkylidene group and R 3 is hydrogen atom, C 1 -C 4 alkyl group or alkali ion, and/or stereoisomers and/or diastereomers and/or pharmaceutically acceptable salts and/or hydrates and/or solvates thereof, which are suitable for the treatment of pain of acute and chronic inflammation origin as well as postoperative pain and dysmenorrhea. The invention also relates to the process of the synthesis of compounds of formula (I) as well as the pharmaceutical composition containing the same and the use for treatment of pain, inflammation and disorders associated with inflammation.

专利号:WO-2006097348-A1
优先权日:2005-03-15
标 题:Use of agents such as nonpolymeric nitric oxide donors for making the lips full again and/or colouring the lips
发明人：CALS-GRIERSON MARIE-MADELEINE
权利人:OREAL; CALS-GRIERSON MARIE-MADELEINE
摘要:The invention relates in particular to the cosmetic use (i) of at least one agent for promoting the production of NO in and/or on the lips, chosen from nitric oxide NO donors or precursors; nonpolymeric NO releasers; and NO synthase synthesis and/or activity stimulators; or (ii) of other agents for promoting microcirculation in the skin, chosen from potassium channel openers; calcium channel blockers; phosphodiesterase inhibitors; flavonoids; vasodilator peptides that are not NO donors; temperature modulators; agents for promoting the stimulation and/or maintenance of angiogenesis; agents for promoting the stimulation of endothelial cell proliferation; agents for promoting endothelial cell migration; and mixtures thereof, in a makeup and/or care composition for the lips, as an agent for naturally making the lips full again and/or naturally coloring the lips. It also relates to specific care and/or makeup compositions for the lips containing said agent, and also to a cosmetic process aimed at making the lips naturally full and/or colored, using said compositions .

专利号:WO-03045369-A9
优先权日:2001-11-29
标题:Use of l isomers of amino acid derivatives of hydroxyguanidine for producing no, pharmaceutical compositions containing same and pharmaceutical uses
发明人：BERANOVA PETRA; KLECHTCHEV ANDREI; MULLER BERNARD; SCHOTT CHRISTA; STOCLET JEAN-CLAUDE; DIJOLS SYLVIE; BOUCHER JEAN-LUC; MANSUY DANIEL
权利人:UNIVERSTE LOUIS PASTEUR ETABLI; CENTRE NAT RECH SCIENT; UNIV PARIS DESCARTES; BERANOVA PETRA; KLECHTCHEV ANDREI; MULLER BERNARD; SCHOTT CHRISTA; STOCLET JEAN-CLAUDE; DIJOLS SYLVIE; BOUCHER JEAN-LUC; MANSUY DANIEL
摘要:The invention concerns synthesis organic chemistry applied in pharmaceutics and concerns the use of the L isomer of a compound of general formula (I), wherein: m is an integer ranging between 0 and 4 (inclusively) for locally producing, in situ and in vivo in the tunicae of human or animal blood vessels, nitrogen monoxide (NO) in the form of NO+ (nitrosonium ion), NO- (nitroxyle ion) or NO° (free radical NO), a nitrogen monoxide precursor or a derivative resulting from the interaction of said nitrogen monoxide with its biological targets. The invention is particularly useful for obtaining novel medicines, in particular for obtaining a medicine for preventing or treating deficiency, lesion or absence of vascular endothelium.

专利号:US-2010160247-A1
优先权日:2008-06-17
标题 :Synthesis of deuterated morpholine derivatives