CAS: 2230273-76-2; 1-(1-Oxo-1,2-Dihydroisoquinolin-5-yl)-5-(Trifluoromethyl)-N-(2-(Trifluoromethyl)Pyridin-4-yl)-1H-Pyrazole-4-Carboxamide

专利信息

专利号:US-6133409-A
优先权日:1996-12-19
标 题:Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
发明人：SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
权利人:AVENTIS PHARM PROD INC
摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha , beta -unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

专利号:US-3959322-A
优先权日:1960-09-22
标 题:Synthesis of 13-alkyl-gon-4-ones
发明人：HUGHES GORDON ALAN; SMITH HERCHEL
权利人:SMITH HERCHEL
摘要:The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-5656634-A
优先权日:1991-03-21
标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
发明人：CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J
权利人:PFIZER
摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

专利号:WO-03086971-A1
优先权日:2002-04-18
标题:Method for synthesising superhard materials
发明人：STARCHENKO IGOR MICHAILOVICH
权利人:STARCHENKO IGOR MICHAILOVICH
摘要:The invention relates to the production of superhard materials including the synthesis of diamonds and cubic boron nitride, polycrystalline and composite materials based thereon, to the production of powders and tools containing such materials and used, in particular for manufacturing abrasive and cutting tools. The aim of said invention is to develop a method for producing superhard materials which makes it possible to ensure the high output of said materials at low temperatures and a relatively low pressure without using catalysts. The inventive method is characterised in that the ultradispersed powder of a material having a cubic structure is used in the form of crystal-forming additives. In one of variants, a diamond ultradispersed powder is used as an ultradispersed powder of a material having a cubic structure. The inventive synthesis of superhard materials (diamond and/or c-BN) is carried out at extremely low temperatures (800-1000 °C low than for catalytic synthesis) and at relatively low pressures. The output of the superhard materials is increased to 96-100 %, said materials being devoid of impurities, thereby making it possible to produce the tools having required structure and characteristics. Said invention significantly reduces energy and costly materials consumption.

专利号:WO-2011032359-A1
优先权日:2009-09-17
标题:Momordica charantia peptide mc-jj6 and microwave promoted solid phase synthesis method thereof
发明人：HUANG WENLONG; JIN JING; QIAN HAI; ZHANG HUIBIN; CHEN WEI; WANG JINGJIE; DU KUO
权利人:UNIV CHINA PHARMA; HUANG WENLONG; JIN JING; QIAN HAI; ZHANG HUIBIN; CHEN WEI; WANG JINGJIE; DU KUO
摘要:Provided are peptides MC-JJ6 and MC-JJ6222 from Momordica charantia with hypoglycemic activity and a microwave promoted solid phase synthesis method thereof. The peptides MC-JJ6 and MC-JJ6222 comprise the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 115, respectively.