CAS: 20595-30-6; Trans-3-Fluorocinnamic Acid

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CAS号110-89-4 六氢吡啶 | CAS号456-48-4 3-氟苯甲醛 | CAS号141-82-2 丙二酸 | CAS号74325-03-4 (E)-3-氟肉桂酸甲酯 | CAS号1664-56-8 2-Propenoic aci... | CAS号456-48-4 3-氟苯甲醛 | CAS号350-51-6 间氟苯乙烯 | CAS号458-45-7 3-氟肉桂酸 | CAS号700-84-5 5-氟-1-茚酮 | CAS号74325-03-4 (E)-3-氟肉桂酸甲酯 | CAS号156868-83-6 3-(3-Fluorophen... | CAS号351-46-2 ETHYL 3 FLUOR°C... | CAS号214045-84-8 6-氟-3,4-二氢-1(2H... | CAS号39098-87-8 3-(3-氟苯基)-2-丙烯酰氯

3-氟苯甲醛置于lithium Hydroxide体系中,用 四氢呋喃,乙醇,二氯甲烷,水 用作溶剂,化学反应 20.0H,反应生成3-氟肉桂酸
参考文献:哌隆定衍生的环磺酰胺(sultams):合成和体外探索对hela癌细胞系的治疗潜力
标题:哌隆定衍生的环磺酰胺(sultams):合成和体外探索对hela癌细胞系的治疗潜力
摘要:设计了带有环磺酰胺(sultam)的新的哌隆金变型,并对其合成进行了描述.我们首次在本文中通过闭环易位方法报道了使用格鲁布斯第二代催化剂(格鲁布斯ii)对天然产物衍生的环状磺酰胺的合成和生物学评估.使用维蒂希反应,闭环易位(rcm)和使用混合酸酐合成酰胺的方法,可以中等至非常好的收率合成一系列由哌啶子丁衍生的阿马甜.评估所有合成的化合物的抗癌活性,并证明其中一些剂量依赖性地降低了hela细胞的生长.在这些7,10和14中,细胞生长明显减少.因此,他们计算出的gi 50 发现该值是0.1或<0.1μm.
Doi:10.1016/j.Ejmech.2016.12.022

专利信息

专利号:US-5981239-A
优先权日:1997-09-24
标 题 :Synthesis of optically active phenylalanine analogs using Rhodotorula graminis
发明人：LIU WEIGUO
权利人:GREAT LAKES CHEMICAL CORP
摘要:A biocatalytic process to produce optically active phenylalanine analogs from arylacrylic acids is disclosed in which Rhodotorula graminis yeast containing phenylalanine ammonia-lyase introduces a molecule of ammonia stereoselectively onto the double bond of a 3-substituted acrylic acid. The substituent at the 3-position of the 3-substituted acrylic acid includes, for example, aromatic rings such as substituted phenyl groups, five member aromatic heterocyclics, and six member aromatic heterocyclics.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-3975429-A
优先权日:1973-11-05
标题:Cyclopropanemethyl esters of cinnamic acid and derivatives thereof
发明人：HENRICK CLIVE A; STAAL GERARDUS B
权利人:ZOECON CORP
摘要:Organic esters and thioesters characterized by the presence of a cyclopropane moiety, synthesis thereof, and compositions thereof for the control of mites and ticks.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.